NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease

Abstract

AimsThe aim of this review is to systematically summarize and analyze the noncoding RNAs (ncRNAs), especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), in the cell apoptosis among Alzheimer's disease (AD) in recent years to demonstrate their value in the diagnosis and treatment of AD.MethodsWe systematically summarized in vitro and in vivo studies focusing on the ncRNAs in the regulation of cell apoptosis among AD in PubMed, ScienceDirect, and Google Scholar.ResultsWe discover three patterns of ncRNAs (including ‘miRNA‐mRNA’, ‘lncRNA‐miRNA‐mRNA’, and ‘circRNA‐miRNA‐mRNA’) form the ncRNA‐based regulatory networks in regulating cell apoptosis in AD.ConclusionsThis review provides a future diagnosis and treatment strategy for AD patients based on ncRNAs.