A distributed Cyber-Physical Systems (CPS) consists of tightly integrated computing, communication and control technologies. Recent CPS hacking incidents had significant consequences. In such a context, reinforcing their resilience, referring to their capacity to recover from disruptions, is a key challenge. Concretely, it involves the integration of mechanisms to regulate safety, security and recovery from adverse events, including plans deployed before, during and after incidents occur. We envision a paradigm change where an increase of adversarial resources does not translate anymore into higher likelihood of disruptions. Consistently with current system design practices in other areas, employing high safety technologies and protocols, we outline a vision for next generation CPS addressing the resilience challenge leveraging ideas such machine learning, fuzzy decision and quantum computing.