Nd:YAG laser combined with IPL treatment improves clinical results in non‐ablative photorejuvenation

Trelles, Mario A.; Allones, Inés; Vélez, Mariano; Mordon, Serge

doi:10.1080/14764170410032398

Cited by 30 publications

(18 citation statements)

References 22 publications

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“…Non-ablative skin rejuvenation techniques, which improve the skin quality without affecting the overlying epidermis have, therefore, been investigated with great interest. By selectively targeting haemoglobin or tissue water as the primary chromophores the mechanism of action is supposed to be based on formation of a dermal repair zone followed by dermal remodeling [4,5].…”

Section: Introductionmentioning

confidence: 99%

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

et al. 2006

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Background and Objective: To compare efficacy and side effects of CO 2 laser resurfacing and intense pulsed light (IPL) rejuvenation for treatment of perioral rhytides. Methods: Twenty-seven female subjects with perioral rhytides (class I-III) were randomly treated with either CO 2 laser or IPL (three monthly treatments). Efficacy was evaluated by patient self-assessments and blinded photographs up to 12 months postoperatively. Side effects were assessed clinically. Non-invasive measurements included: trans epidermal water loss (TEWL), skin reflectance, skin elasticity, and ultrasound. Results: CO 2 laser resurfacing resulted in higher degrees of patient satisfaction and clinical rhytide reduction compared to IPL rejuvenation up to 12 months postoperatively (patient evaluations, P < 0.05) (observer evaluations, P < 0.008). Laser-induced side effects included erythema, dyspigmentation, and milia whereas no side effects were observed after IPL rejuvenation. Non-invasive measurements showed a significant higher reduction of the subepidermal low-echogenic band in CO 2 laser treated areas versus IPL treated areas (12 months postoperatively, P < 0.001). Skin elasticity (expressed as Young's modulus) increased in both groups (P ¼ ns). One month postoperatively a significant increase in TEWL values (P < 0.009) and skin redness% (P < 0.02) was found in CO 2 laser treated patients versus IPL treated patients. No significant differences were seen in skin pigmentation% during the observation period. Conclusion: CO 2 laser resurfacing induces a significantly higher degree of clinical rhytide reduction followed by considerably more side effects compared to IPL rejuvenation in a homogeneous group of patients.

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Section: Introductionmentioning

confidence: 99%

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

et al. 2006

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“…Then the light intensity can be lowered to about 4 J/cm 2 in order to stimulate growth factors and fibroblast proliferation for the healing process. The high intensity visible light may also stimulate human cells to secrete connecting factors like collagen, leading to faster closure of the wounds [40]. This ability of high intensity light is used widely in photo-rejuvenation.…”

Section: Discussionmentioning

confidence: 99%

A possible mechanism for visible light‐induced wound healing

2008

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“…The very good histological evidence of tightening of the typically elastotic dermis failed to be echoed in a younger-looking epidermis, and patient satisfaction with single modality non-ablative skin rejuvenation was extremely low (7)(8)(9)(10). The combination of single modality systems based on wavelength-specific photobiological precepts produced much better visible results (11)(12)(13).…”

Section: Viewpointmentioning

confidence: 99%

“…Elimination of oxidized proteins is mainly achieved through degradation by the proteasomal system (6,7) while certain oxidative protein modifications such as oxidation of methionine residues can be reversed within proteins by the methionine sulfoxide reductases (Msrs) system which represents one of the few repair mechanisms for oxidized proteins (8)(9)(10). Both systems have been documented to generally exhibit an age-related decline (11)(12)(13), notably for the proteasome in human epidermal cells and dermal fibroblasts (14)(15)(16)(17).…”

Section: Viewpointmentioning

confidence: 99%

Viewpoint 3

Trelles¹,

Mordon²,

Calderhead³

2008

Experimental Dermatology

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type I collagen in the dermis (16,36). These observations demonstrate the role of retinoids in both preventing and reversing the signs of UV-induced skin ageing.In conclusion, despite the vast array of 'antiageing' products now available topical retinoids and sunscreens remain the most tried and tested treatments with long established safety records and proven efficacy in the treatment and prevention of UV-induced skin ageing.Stephanie Ogden, Christopher EM Griffiths 13 Sendagorta E, Lesiewicz J, Armstrong R B. J Am Acad Dermatol 1992: 27: S15-S18. Viewpoint 3Excessive skin exposure to solar UV brings about detrimental histological changes in the skin, which combine with and accelerate the effects of chronological ageing, and which result in the lax, dull and wrinkled appearance of 'old' skin. UV photochemically generated oxidative stressors such as singlet oxygen damage matrix integrity; elastosis-inducing damage to the underlying connective tissue occurs, with interstitial spaces appearing in the matrix caused by loss of collagen volume and fibre binding; the viscosity and quality of the matrix ground substance glycosaminoglycans is reduced; and an inflammatory infiltrate can be identified (1).The elegant idea of using light to repair the damage caused by overexposure to light was heralded by the indication of first the CO 2 and the Er:YAG lasers in the early 1990s, (2-4) and then a system which combined both wavelengths in the one console (5,6). Although still regarded as the 'gold standard' in the rejuvenation of seriously photoaged skin, laser ablative resurfacing is simply a controlled second degree burn of the dermis and is associated with, at best, unpleasant side effects and a long downtime.A non-ablative approach using lasers and intense pulsed light (IPL) systems delivered a zone of controlled dermal photothermal damage under an intact epidermis to 'kickstart' the wound healing process recognized as essential in successful skin rejuvenation. The very good histological evidence of tightening of the typically elastotic dermis failed to be echoed in a younger-looking epidermis, and patient satisfaction with single modality non-ablative skin rejuvenation was extremely low (7-10). The combination of single modality systems based on wavelength-specific photobiological precepts produced much better visible results (11-13).Fractional photothermolysis was next proposed for skin rejuvenation (14,15), to bridge the gap between ablative and non-ablative technologies by delivering controlled microdamage to both the epidermis and dermis. Some good results have been reported, but patient satisfaction has again been fickle with fractional technology on its own,

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Nd:YAG laser combined with IPL treatment improves clinical results in non‐ablative photorejuvenation

Cited by 30 publications

References 22 publications

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

A possible mechanism for visible light‐induced wound healing

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