NDM-1 carbapenemase-producing Salmonella enterica subsp. enterica serovar Corvallis isolated from a wild bird in Germany

Fischer, Jennie; Schmoger, Silvia; Jahn, Silke; Helmuth, Reiner; Guerra, Beatriz

doi:10.1093/jac/dkt260

Cited by 88 publications

(70 citation statements)

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“…Alarmingly, while the previous report of carbapenem‐resistant bacteria in a wild bird was a single case in a raptor (Fischer, Schmoger, Jahn, Helmuth, & Guerra, 2013), we detected VIM‐1‐bearing E. coli carriage in 18 different chicks, which raises the question of the extent of wildlife contamination in the study region. Interestingly, we identified 5 clonal complexes and one unique genotype within the VIM‐1‐containing bacteria we detected (Figure 2).…”

Section: Discussioncontrasting

confidence: 71%

VIM‐1 carbapenemase‐producing Escherichia coli in gulls from southern France

Vittecoq

Laurens

Brazier

et al. 2017

Ecology and Evolution

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Acquired carbapenemases currently pose one of the most worrying public health threats related to antimicrobial resistance. A NDM‐1‐producing Salmonella Corvallis was reported in 2013 in a wild raptor. Further research was needed to understand the role of wild birds in the transmission of bacteria resistant to carbapenems. Our aim was to investigate the presence of carbapenem‐resistant Escherichia coli in gulls from southern France. In 2012, we collected 158 cloacal swabs samples from two gull species: yellow‐legged gulls (Larus michahellis) that live in close contact with humans and slender‐billed gulls (Chroicocephalus genei) that feed at sea. We molecularly compared the carbapenem‐resistant bacteria we isolated through culture on selective media with the carbapenem‐susceptible strains sampled from both gull species and from stool samples of humans hospitalized in the study area. The genes coding for carbapenemases were tested by multiplex PCR. We isolated 22 carbapenem‐resistant E. coli strains from yellow‐legged gulls while none were isolated from slender‐billed gulls. All carbapenem‐resistant isolates were positive for bla VIM ‐1 gene. VIM‐1‐producing E. coli were closely related to carbapenem‐susceptible strains isolated from the two gull species but also to human strains. Our results are alarming enough to make it urgently necessary to determine the contamination source of the bacteria we identified. More generally, our work highlights the need to develop more bridges between studies focusing on wildlife and humans in order to improve our knowledge of resistant bacteria transmission routes.

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Section: Discussioncontrasting

confidence: 71%

VIM‐1 carbapenemase‐producing Escherichia coli in gulls from southern France

Vittecoq

Laurens

Brazier

et al. 2017

Ecology and Evolution

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“…On the same plasmid, two class 1 integrons (carrying dfrA1-aadA5 or aacA4) as well as floR, tet(A), strA/B, and sul1, sul2 were co-localized (Fischer et al, 2013c).…”

Section: Mobile Genetic Elements Involved In Transmission Of Carbapenmentioning

confidence: 99%

Scientific Opinion on Carbapenem resistance in food animal ecosystems

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2013

EFS2

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Carbapenems are broad-spectrum β-lactam antimicrobials used for the treatment of serious infections in humans. To date only sporadic studies have reported the occurrence of carbapenemase-producing (CP) bacteria in foodproducing animals and their environment. The bacteria and enzymes isolated include VIM-1 producing Escherichia coli and Salmonella Infantis from pigs and poultry in Germany, OXA-23-producing Acinetobacter spp. from cattle and horses in France and Belgium, and NDM-producing Acinetobacter spp. from pigs and poultry in China. In the German S. Infantis and E. coli isolates, the VIM-1-encoding genes were located on IncHI2 plasmids. A methodology including selective culture is proposed for the detection of CP strains of Enterobacteriaceae and Acinetobacter spp. The choice of selective media for the surveillance of carbapenem resistance for testing animal and food samples needs to be experimentally evaluated and validated. Biochemical and phenotypic tests for the confirmatory identification of CP bacteria are available. For CP bacteria in animals and food, active/passive monitoring and/or targeted surveys should cover key zoonotic agents, animal pathogens and indicator organisms. Priority should be given to broilers, fattening turkeys, fattening pigs, veal calves and meat thereof. Because there are no data on the comparative efficacy of individual control options, prioritisation is complex. Continued prohibition of the use of carbapenems in food-producing animals would be a simple and effective option. As genes encoding carbapenemase production are mostly plasmid-mediated, and co-resistance may be an important issue in the spread of such resistance mechanisms, decreasing the frequency of use of antimicrobials in animal production in the EU in accordance with prudent use guidelines is also of high priority. The effectiveness of any control measures should be monitored by targeted surveys, using selective isolation methods and pre-enrichment of samples. Control measures should be proactively implemented at national and international levels to prevent CP strains become widespread in livestock. SUMMARYThe European Food Safety Authority (EFSA) asked the Panel on Biological Hazards (BIOHAZ) to provide a scientific opinion on the carbapenem resistance in food animal ecosystems. Carbapenems are broad-spectrum beta (β)-lactam antimicrobials mostly used for the treatment of serious infections in humans, frequently in hospitalised patients, and are considered last-line therapy for infections caused by multidrug-resistant Gram-negative bacteria. In particular, the panel was asked: (i) to define the carbapenemase-producing (CP) bacterial strains and genes relevant for public health and linked to food-producing animals or food-borne transmission; (ii) to review the information on the epidemiology of acquired resistance to carbapenems, including the genes coding for such resistance, in food-producing animals and food; (iii) to perform a critical analysis of the methods (phenotypic and genotypic) and the interpr...

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“…The bla NDM-1 -carrying genetic determinants have been localized on a variety of rare and frequent plasmid types (5). Here, the complete sequence of the bla NDM-1 -carrying IncA/C plasmid (pRH-1238), identified in a Salmonella enterica serovar Corvallis strain isolated from a wild bird (Milvus migrans) in Germany (6), was determined.…”

mentioning

confidence: 99%

“…pRH-1238 is the first completely sequenced bla NDM-1 -fosA3-IncA/C plasmid and is of particular interest because it was identified in Salmonella from a wild animal in Germany (6). The report of this broad-host-range plasmid, which confers multidrug resistance in Salmonella identified in wildlife in Europe, is worrisome.…”

mentioning

confidence: 99%

IncA/C Plasmid Carrying bla _NDM-1 , bla _CMY-16 , and fosA3 in a Salmonella enterica Serovar Corvallis Strain Isolated from a Migratory Wild Bird in Germany

Villa

Guerra

Schmoger

et al. 2015

Antimicrob Agents Chemother

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A Salmonella enterica serovar Corvallis strain was isolated from a wild bird in Germany. This strain carried the IncA/C 2 pRH-1238 plasmid. Complete sequencing of the plasmid was performed, identifying the bla NDM-1 , bla CMY-16 , fosA3, sul1, sul2, strA, strB, aac(6=)-Ib, aadA5, aphA6, tetA(A), mphA, floR, dfrA7, and merA genes, which confer clinically relevant resistance to most of the antimicrobial classes, including ␤-lactams with carbapenems, fosfomycin, aminoglycosides, co-trimoxazole, tetracyclines, and macrolides. The strain likely originated from the Asiatic region and was transferred to Germany through the Milvus migrans migratory route.

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NDM-1 carbapenemase-producing Salmonella enterica subsp. enterica serovar Corvallis isolated from a wild bird in Germany

Cited by 88 publications

References 8 publications

VIM‐1 carbapenemase‐producing Escherichia coli in gulls from southern France

VIM‐1 carbapenemase‐producing Escherichia coli in gulls from southern France

Scientific Opinion on Carbapenem resistance in food animal ecosystems

IncA/C Plasmid Carrying bla _NDM-1 , bla _CMY-16 , and fosA3 in a Salmonella enterica Serovar Corvallis Strain Isolated from a Migratory Wild Bird in Germany

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NDM-1 carbapenemase-producing Salmonella enterica subsp. enterica serovar Corvallis isolated from a wild bird in Germany

Cited by 88 publications

References 8 publications

VIM‐1 carbapenemase‐producing Escherichia coli in gulls from southern France

VIM‐1 carbapenemase‐producing Escherichia coli in gulls from southern France

Scientific Opinion on Carbapenem resistance in food animal ecosystems

IncA/C Plasmid Carrying bla NDM-1 , bla CMY-16 , and fosA3 in a Salmonella enterica Serovar Corvallis Strain Isolated from a Migratory Wild Bird in Germany

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IncA/C Plasmid Carrying bla _NDM-1 , bla _CMY-16 , and fosA3 in a Salmonella enterica Serovar Corvallis Strain Isolated from a Migratory Wild Bird in Germany