NDM-1-encoding plasmid in Acinetobacter chengduensis isolated from coastal water

Emergence of an Extensive Drug Resistant Citrobacter portucalensis Clinical Strain Harboring blaSFO-1, blaKPC-2, and blaNDM-1

“…According to previous studies, ISAba125 is typically involved in the formation of Tn125, a complex transposon associated with the plasmid-mediated spread of bla NDM-1 . 32,33 Our findings suggest that the lack of ISAba125 does not impede the horizontal transfer of bla NDM-1 . In the conjugation experiment, we successfully transferred bla NDM-1 and bla KPC-2 into EC600 for expression, affirming the transferability of the plasmids in our study.…”

Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America

“…Alarmingly, increasing reports of WHO critical priority Gram-negative pathogens (MCR-type, carbapenemaseand/or ESBL-producing bacteria) on the Brazilian coast have been occurred in the last decade, which may indicate, in part, the adaptation of such pathogens in the sea. In this regard, the occurrence of such bacteria was documented in coastal waters from in densely coastal areas (Montezzi et al, 2015;Campana et al, 2017;Fernandes et al, 2017Fernandes et al, , 2020aPaschoal et al, 2017;Sellera et al, 2017a;Corrêa et al, 2021;Furlan et al, 2021;Cordeiro-Moura et al, 2022), in marine fishes (Sellera et al, 2018a) and benthic invertebrates (Sellera et al, 2018b;Monte et al, 2019;Fernandes et al, 2020b), and also infecting penguins (Sellera et al, 2017b;Wink et al, 2021), a sea turtle (Goldberg et al, 2019), and a dolphin (Fuentes-Castillo et al, 2021b). More specifically, the presence of NDM-1-producing bacteria have been so far identified in K. pneumoniae and Acinetobacter chengduensis from coastal waters of Rio de Janeiro (Campana et al, 2017;Paschoal et al, 2017;Corrêa et al, 2021), whereas a single case of E. coli carrying bla NDM−1 infecting a penguin was also documented in the South coast of Brazil (Wink et al, 2021).…”

New Delhi metallo-β-lactamase-1-producing Citrobacter portucalensis belonging to the novel ST264 causing fatal sepsis in a vulnerable migratory sea turtle

“…Antibiotic-resistant bacteria are found in people, animals, food and in the environment around the world. Although, some studies have reported the presence of carbapenemase-producing bacteria in coastal waters [ [6] , [7] , [8] , [9] , [10] , [11] ], marine wildlife has been overlooked in the epidemiology of WHO critical priority pathogens. However, since anthropogenic pollution of aquatic ecosystems has been a growing global phenomenon, increasing rates of clinically significant antibiotic-resistant bacteria in the marine environment and its wildlife could be expected [ 6 ].…”