NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization

Wang, Kaibing; Xie, Rui; Li, Xi; Li, Kunpeng; Bai, Yuxian; Wang, Xishan; Bai, Bin; Chen, Dan; Li, Jiazhuang; Shen, Baogen

doi:10.18632/oncotarget.16563

Cited by 16 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NDV strain 73T is now under phase II clinical trial by NCI, USA, for the treatment of Melanoma 9 . NDV strains V4UPM, AF2240, D90 were also shown to have oncolytic properties in various cancer cells 10–12 . Tumor cells generally have a defective antiviral response, which supports replication of NDV 13 .…”

Section: Introductionmentioning

confidence: 99%

Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: A probable role of β-catenin and matrix metalloproteinase-7

Morla

Kumar

2019

Sci Rep

View full text Add to dashboard Cite

Cancer cell metastasis and its dissemination are most enigmatic and challenging aspects in the development of its therapeutics. Newcastle disease virus (NDV) is a well-studied avian paramyxovirus frequently isolated from birds and rarely from mammals. Since the first report of its oncolytic property, many NDV strains were studied for its effect in various cancer cells. In the present study, NDV strain Bareilly was characterized for its apoptotic potential and migration inhibition in human oral cancer cells. The NDV mediated apoptosis was confirmed by flow cytometry, DNA laddering, and immunoblotting. Moreover, NDV decreased the mitochondrial membrane potential suggesting an intrinsic pathway of apoptosis in oral cancer cells. NDV infection in oral cancer cells results in migration inhibition by a reduction in levels of MMP-7. MMP-7 is one of the key target genes of β-catenin. While overexpression of MMP-7 reversed the inhibitory effect of NDV mediated migration suggested its possible involvement. Wnt/β-catenin is an essential pathway for cell growth, differentiation, and metastasis. The involvement of the Wnt/β-catenin pathway in NDV infection has never been reported. Our results showed that NDV dysregulates Wnt/β-catenin by down-regulation of p-Akt and p-GSK3β leading to degradation of β-catenin. Furthermore, NDV infection leads to a reduction in cytoplasmic and nuclear levels of β-catenin. The study will provide us with a better insight into the molecular mechanism of NDV mediated oncolysis and the key cellular partners involved in the process.

show abstract

Section: Introductionmentioning

confidence: 99%

Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: A probable role of β-catenin and matrix metalloproteinase-7

Morla

Kumar

2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Both TMZ and NDV induce GBM apoptosis in vitro through AMPK activation, but this AMPK activation is not the only mechanism responsible for the effect of TMZ and NDV 3 , 12 . NDV, as a type of OV, operates via a complex mechanism 1 , 8 , 19 – 23 . Our experiments confirmed that NDV inhibits AKT and activates AMPK when combined with TMZ.…”

Section: Discussionmentioning

confidence: 99%

“… 1 , 14 . Moreover, NDV has good anti-tumor potential according to studies investigating other tumor types 4 , 11 , 14 , 15 , 20 , 22 , 23 .…”

Section: Discussionmentioning

confidence: 99%

Newcastle disease virus enhances the growth-inhibiting and proapoptotic effects of temozolomide on glioblastoma cells in vitro and in vivo

Bai

Chen

Hong

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Glioblastoma (GBM) is the most serious and most common brain tumor in humans. Despite recent advances in the diagnosis of GBM and the development of new treatments, the prognosis of patients has not improved. Multidrug resistance, particularly resistance to temozolomide (TMZ), is a challenge in combating glioma, and more effective therapies are needed. Complementary treatment with the LaSota strain of the naturally oncolytic Newcastle disease virus (NDV-LaSota) is an innovation. In our experiments, the combination therapy of NDV-LaSota and temozolomide (TMZ) was more effective than either treatment alone in inducing apoptosis in glioma cells. NDV can function as a tumor cell selective approach to inhibit AKT and activate AMPK. Consequently, mTOR, 4EBP1 and S6K were also suppressed. The combination therapy of NDV and TMZ also significantly extended survival in a rat xenograft tumor model. In conclusion, NDV suppress AKT signaling and enhances antitumor effects of TMZ. Our study provides one of the theoretical basis for the use of a combined therapy of TMZ and NDV, which could benefit GBM patients.

show abstract

“…Newcastle disease viruses (NDV)-D90 induce gastric cancer cell apoptosis by stimulation of p38 signalling, suppression of ERK1/2 and Akt signalling, and angiogenesis inhibition. 112 In vivo , orthotopic injection of NDV-D90 impaired tumour growth and induced intratumoural necrosis, and clinical trials of other oncolytic viruses including recombinant vesicular stomatitis virus are underway [ClinicalTrials.gov identifier: NCT02923466].…”

Section: Role Of Combination Of Icpi With Chemotherapy Targeted Thermentioning

confidence: 99%

The evolving immunotherapeutic landscape in advanced oesophagogastric cancer

et al. 2018

View full text Add to dashboard Cite

Improvements in median overall survival in the advanced oesophagogastric (OG) setting have plateaued, underlining the need for improved therapeutic approaches in this patient population. Immunotherapeutics are inducing unexpected durable responses in an expanding list of advanced disease indications. Although OG cancers have traditionally been considered to be more challenging to treat with immunotherapy than some other malignancies because of their variable tumour mutational burden and relative scarcity of infiltrating T cells, immune checkpoint inhibitor (ICPI) trials conducted over the last few years suggest there is an important role for these treatments. ICPI efficacy may be demonstrated in specific molecular subtypes of OG cancer. This review outlines the improvements in defining predictive biomarkers of responsiveness to ICPIs. Increasingly, identification of an expanding list of ICPI resistance mechanisms will drive biomarker-directed research. In addition, the specific rationale to combine ICPIs with chemotherapies, radiotherapies, targeted therapies and other novel immunotherapeutic drugs will be discussed.

show abstract

NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization

Cited by 16 publications

References 25 publications

Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: A probable role of β-catenin and matrix metalloproteinase-7

Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: A probable role of β-catenin and matrix metalloproteinase-7

Newcastle disease virus enhances the growth-inhibiting and proapoptotic effects of temozolomide on glioblastoma cells in vitro and in vivo

The evolving immunotherapeutic landscape in advanced oesophagogastric cancer

Contact Info

Product

Resources

About