Near-field electrospinning of polymer/phage whispering gallery mode microfiber resonators for label-free biosensing

Hsieh, Stephen T.; Cheeney, Joseph; Ding, Xi; Myung, Nosang V.; Haberer, Elaine D.

doi:10.1016/j.snb.2022.132062

Cited by 15 publications

(5 citation statements)

References 62 publications

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“…This paper-based material is easy to prepare and can be used for in situ detection. In another example, a streptavidin-binding peptide was displayed on the pVIII protein of M13 phages for the label-fee optical detection of streptavidin [65]. Polymer biosensor PVA/M13 fibers were prepared in a one-step process using a blend near-field electrospinning technique (blend NFES), with the streptavidin-specific M13 phage as affinity capture agent, and rhodamine 6G as a high-yield fluorescent signal source.…”

Section: M13 Phage As Capture Antibodymentioning

confidence: 99%

M13 phage: a versatile building block for a highly specific analysis platform

Wang

Cao

et al. 2023

Anal Bioanal Chem

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Viruses are changing the biosensing and biomedicine landscape due to their multivalency, orthogonal reactivities, and responsiveness to genetic modifications. As the most extensively studied phage model for constructing a phage display library, M13 phage has received much research attention as building blocks or viral scaffolds for various applications including isolation/separation, sensing/probing, and in vivo imaging. Through genetic engineering and chemical modification, M13 phages can be functionalized into a multifunctional analysis platform with various functional regions conducting their functionality without mutual disturbance. Its unique filamentous morphology and flexibility also promoted the analytical performance in terms of target affinity and signal amplification. In this review, we mainly focused on the application of M13 phage in the analytical field and the benefit it brings. We also introduced several genetic engineering and chemical modification approaches for endowing M13 with various functionalities, and summarized some representative applications using M13 phages to construct isolation sorbents, biosensors, cell imaging probes, and immunoassays. Finally, current issues and challenges remaining in this field were discussed and future perspectives were also proposed.

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Section: M13 Phage As Capture Antibodymentioning

confidence: 99%

M13 phage: a versatile building block for a highly specific analysis platform

Wang

Cao

et al. 2023

Anal Bioanal Chem

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“…Whispering gallery mode (WGM) resonators have garnered interest as optical biosensors because of their ability to quickly identify substances without the need for labeling [90]. Polyvinyl alcohol (PVA) bioreceptors containing M13 bacteriophage were prepared by near-field electrospinning [91]. Streptavidin-binding phage and rhodamine 6 G were used as representative virus-based biocapture agents and potent fluorescent sources, respectively.…”

Section: Optical Biosensorsmentioning

confidence: 99%

Multifunctional Electrospun Nanofibers for Biosensing and Biomedical Engineering Applications

Chen,

Guan,

Bian

et al. 2023

Biosensors

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Nanotechnology is experiencing unprecedented developments, leading to the advancement of functional nanomaterials. The properties that stand out include remarkable porosity, high-specific surface area, excellent loading capacity, easy modification, and low cost make electrospun nanofibers. In the biomedical field, especially in biosensors, they exhibit amazing potential. This review introduces the principle of electrospinning, describes several structures and biomaterials of electrospun nanofibers used for biomedicine, and summarizes the applications of this technology in biosensors and other biomedical applications. In addition, the technical challenges and limitations of electrospinning for biomedicine are discussed; however, more research work is needed to elucidate its full potential.

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“…[121] Chen et al on the other hand, introduced an artificial neural network technique to compensate the nonlinear error due to temperature-induced geometrical deformation of the MKR when it is used for current sensing, which provides an effective and flexible method to improve the performance of the sensor in real time. [122] So far, some microfiber-based resonators have also proved to be useful for biomass detection, for example, a label-free methylation-specific sensor based on a silicon micro-ring resonator can be used for the detection and quantification of DNA methylation biomarkers in bladder cancer, [123] functionalized whispering gallery mode resonators exhibit specific labelfree biosensing of streptavidin, [124] encapsulated thin-walled microbubble resonators can perform label-free detection of cardiac troponin-I for label-free specific detection [125] and so on. In addition, since MKRs are sensitive to external refractive index changes, MKRs as a type of fiber-optic micro-resonators also have excellent potential for biometric measurements.…”

Section: Other Sensingmentioning

confidence: 99%

“…So far, some microfiber‐based resonators have also proved to be useful for biomass detection, for example, a label‐free methylation‐specific sensor based on a silicon micro‐ring resonator can be used for the detection and quantification of DNA methylation biomarkers in bladder cancer, [ 123 ] functionalized whispering gallery mode resonators exhibit specific label‐free biosensing of streptavidin, [ 124 ] encapsulated thin‐walled microbubble resonators can perform label‐free detection of cardiac troponin‐I for label‐free specific detection [ 125 ] and so on. In addition, since MKRs are sensitive to external refractive index changes, MKRs as a type of fiber‐optic micro‐resonators also have excellent potential for biometric measurements.…”

Section: Mkr Sensing Applicationsmentioning

confidence: 99%

Microfiber Knot Resonators: Structure, Spectral Properties, and Sensing Applications

Zhang,

Gao,

Xia

et al. 2023

Laser & Photonics Reviews

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In recent years, compact micro‐/nanofiber sensors with fast response and high resolution have become a hot field in sensing and nanotechnology. In addition to the unique properties of microfibers such as strong evanescent field, low optical loss, and easy integration, microfiber knot resonators further improve the sensing capability due to their resonance properties. The potential high‐quality factor allows higher sensing sensitivity and resolution, which is very attractive for optical sensing at the micro‐/nano scale. More application potential can be effectively stimulated by improving the structure shape or principle or combining with functional sensitive materials. This paper first introduces the preparation process and spectral characteristics of conventional microfiber knots and then focuses on three new types of devices for enhancing the sensing performance, namely material‐coated, shape‐improved, and principle‐extended, and briefly analyzes their spectral properties. In addition, the research progress and applications of these sensors are summarized. Finally, the existing problems in this field are analyzed, and the directions for further development are discussed and prospected.

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Near-field electrospinning of polymer/phage whispering gallery mode microfiber resonators for label-free biosensing

Cited by 15 publications

References 62 publications

M13 phage: a versatile building block for a highly specific analysis platform

M13 phage: a versatile building block for a highly specific analysis platform

Multifunctional Electrospun Nanofibers for Biosensing and Biomedical Engineering Applications

Microfiber Knot Resonators: Structure, Spectral Properties, and Sensing Applications

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