Near-Field Scanning Optical Microscopy Enables Direct Observation of Moiré Effects at the Nanometer Scale

Lin, Wei; Li, Jie-Ren; Liu, Gang

doi:10.1021/nn303407j

Cited by 15 publications

(15 citation statements)

References 52 publications

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“…68–71 Polished silicon wafers were cleaned by immersion in piranha solution for 1 h and subsequently in basic solution at 70 ºC for 1 h. Piranha solution was prepared by mixing sulfuric acid and hydrogen peroxide at a volume ratio of 3:1. It is highly corrosive and should be handled carefully.…”

Section: Methodsmentioning

confidence: 99%

Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells

Ross

Liu

et al. 2015

ACS Nano

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A recent finding reports that co-stimulation of the high-affinity immunoglobulin E (IgE) receptor (FcεRI) and the chemokine receptor 1 (CCR1) triggered formation of membrane nanotubes among bone-marrow-derived mast cells. The co-stimulation was attained using corresponding ligands: IgE binding antigen and macrophage inflammatory protein 1α (MIP1 α), respectively. However, this approach failed to trigger formation of nanotubes among rat basophilic leukemia (RBL) cells due to the lack of CCR1 on the cell surface (Int. Immunol. 2010, 22 (2), 113–128). RBL cells are frequently used as a model for mast cells and are best known for antibody-mediated activation via FcεRI. This work reports the successful formation of membrane nanotubes among RBLs using only one stimulus, a hapten of 2,4-dinitrophenyl (DNP) molecules, which are presented as nanostructures with our designed spatial arrangements. This observation underlines the significance of the local presentation of ligands in the context of impacting the cellular signaling cascades. In the case of RBL, certain DNP nanostructures suppress antigen-induced degranulation and facilitate the rearrangement of the cytoskeleton to form nanotubes. These results demonstrate an important scientific concept; engineered nanostructures enable cellular signaling cascades, where current technologies encounter great difficulties. More importantly, nanotechnology offers a new platform to selectively activate and/or inhibit desired cellular signaling cascades.

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Section: Methodsmentioning

confidence: 99%

Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells

Ross

Liu

et al. 2015

ACS Nano

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“…These silica spheres served as a mask for subsequent Cu vapor deposition via thermal evaporation. 32,35–37 The incident angle of the deposition can be varied from 0° to 55°. 32 In creating the patterns in Figure 1, we chose 30° with respect to the surface normal.…”

Section: Resultsmentioning

confidence: 99%

Particle Lithography Enables Fabrication of Multicomponent Nanostructures

Lin

Swartz

et al. 2013

J. Phys. Chem. C

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Multicomponent nanostructures with individual geometries have attracted much attention because of their potential to carry out multiple functions synergistically. The current work reports a simple method using particle lithography to fabricate multicomponent nanostructures of metals, proteins, and organosiloxane molecules, each with its own geometry. Particle lithography is well-known for its capability to produce arrays of triangular-shaped nanostructures with novel optical properties. This paper extends the capability of particle lithography by combining a particle template in conjunction with surface chemistry to produce multicomponent nanostructures. The advantages and limitations of this approach will also be addressed.

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“…The goal of this step is to prepare a set of surfaces with designated solution-philicity using SAMs on glass surfaces. Glass slides were cleaned following the previously reported protocols. − In brief, substrates were cleaned using piranha solution by immersion for 1 h, then rinsed with copious quantities of ultrapure water. Piranha solution is a mixture of sulfuric acid and hydrogen peroxide at a (v/v) ratio of 3:1.…”

Section: Experimental Methodsmentioning

confidence: 99%

New Means to Control Molecular Assembly

Zhang

Harris

et al. 2020

J. Phys. Chem. C

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While self-assembly of molecules is relatively well-known and frequently utilized in chemical synthesis and materials science, controlled assembly of molecules represents a new concept and approach. The present work demonstrates the concept of controlled molecular assembly using a nonspherical biomolecule, heparosan tetrasaccharide (MW = 1.099 kD). The key to controlled assembly is the fact that ultrasmall solution droplets exhibit different evaporation dynamics from those of larger ones. Using an independently controlled microfluidic probe in an atomic force microscope, sub-femtoliter aqueous droplets containing designed molecules produce well-defined features with dimensions as small as tens of nanometers. The initial shape of the droplet and the concentration of solute within the droplet dictate the final assembly of molecules because of the ultrafast evaporation rate and dynamic spatial confinement of the droplets. The level of control demonstrated in this work brings us closer to programmable synthesis for chemistry and materials science which can be used to develop vehicles for drug delivery and three-dimensional nanoprinting in additive manufacturing.

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Near-Field Scanning Optical Microscopy Enables Direct Observation of Moiré Effects at the Nanometer Scale

Cited by 15 publications

References 52 publications

Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells

Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells

Particle Lithography Enables Fabrication of Multicomponent Nanostructures

New Means to Control Molecular Assembly

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