The main flow could be unsteady in flow fields of film cooling for several reasons such as flow interactions between the rotor and the stator in the turbine. Understanding the characteristics of the film-cooling flow with an unsteady flow is important in the design of gas turbines. The effects of 36-Hz pulsations in the main flow on the streamwise velocity distributions, turbulence statistics, and temperature fluctuations in the film-cooling flow from a cylindrical hole with an orientation angle are investigated by numerical methods. Large-eddy simulation (LES) results match the experimental data with an acceptable accuracy, whereas the Reynolds-averaged Navier–Stokes simulation (RANS) results show large deviations with the experimental data and the LES results. Under 36-Hz pulsations, the URANS results predict a weaker streamwise velocity of the coolant jet that blocks the main flow compared with the LES. With 36-Hz pulsations at the time-averaged blowing ratio of 0.5, urms, the root mean squared fluctuating velocity in the streamwise direction around the coolant core increased due to intensive mixing, and vrms, the root mean squared fluctuating velocity in the wall-normal direction, increased along the trajectory of the injected coolant. Moreover, wrms, the root mean squared fluctuating velocity in the spanwise direction, increased around the wall compared to those at a steady state. The dimensionless temperature fluctuations increased in the region of the core of the coolant compared with those at a steady state. When the orientation angle was 30°, the distribution of the results moved in the z-direction; however, the overall trend was similar to that of a simple angle.