Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites

Chen, Ai‐Zheng; Tang, Hanxiao; Zheng, Xiang; Yang, Dayun; Zhang, Yang; Zhang, Jian-Ting; Kankala, Ranjith Kumar; Wang, Shibin; Liu, Gang

doi:10.1021/acsami.0c11739

Cited by 48 publications

(31 citation statements)

References 42 publications

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“…As a highly biocompatible family of clay nanomaterials, sheet-like layered double hydroxide (LDH) nanoparticles are extensively explored as a multimodal delivery carrier with the advantages of passive targeting via enhanced penetration and retention (EPR) effect, sheet-like morphology, high loading capacity, and versatile composition. − For example, two FDA-approved therapeutics, 5-fluorouracil (5-FU) and siRNA, were integrated into LDH nanosheets for combined chemotherapy and RNAi therapy . Recently, our research demonstrated that effective photothermal conversion of Cu-doped LDH (Cu-LDH) exhibited almost complete tumor inhibition together with chemotherapeutic drug 5-FU .…”

Section: Introductionmentioning

confidence: 99%

Synergistic Cancer Photochemotherapy via Layered Double Hydroxide-Based Trimodal Nanomedicine at Very Low Therapeutic Doses

Liu

Sun

et al. 2021

ACS Appl. Mater. Interfaces

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The success of cancer therapy is always accompanied by severe side effects due to the high amount of toxic antitumor drugs that off-target normal organs/tissues. Herein, we report the development of a trifunctional layered double hydroxide (LDH) nanosystem for combined photochemotherapy of skin cancer at very low therapeutic doses. This nanosystem (ICG/Cu-LDH@BSA–DOX) is composed of acid-responsive bovine serum albumin–doxorubicin prodrug (BSA–DOX) and indocyanine green (ICG)-intercalated Cu-doped LDH nanoparticle. ICG/Cu-LDH@BSA–DOX is able to release DOX in an acid-triggered manner, efficiently and simultaneously generates heating and reactive oxygen species (ROS) upon 808 nm laser irradiation, and synergistically induces apoptosis of skin cancer cells. In vivo therapeutic evaluations demonstrate that ICG/Cu-LDH@BSA–DOX nearly eradicated the tumor tissues upon one-course treatment using very low doses of therapeutic agents (0.175 mg/kg DOX, 0.5 mg/kg Cu, and 0.25 mg/kg ICG) upon very mild 808 nm laser irradiation (0.3 W/cm2 for 2 min). This work thus provides a novel strategy to design anticancer nanomedicine for efficient combination cancer treatment with minimal side effects in clinical applications.

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Section: Introductionmentioning

confidence: 99%

Synergistic Cancer Photochemotherapy via Layered Double Hydroxide-Based Trimodal Nanomedicine at Very Low Therapeutic Doses

Liu

Sun

et al. 2021

ACS Appl. Mater. Interfaces

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“…Additionally, CuS is a well-reported PTA, exhibiting wide absorption range in the NIR window [134]. It was also reported that CuS can produce a huge amount of ROS for PDT upon NIR irradiation, which is realized via the Fenton-like reaction or Haber-Weiss reaction [135,136]. Thus, as promising candidates for phototherapy, CuS combined with immunotherapy can achieve very good immune responses for cancer treatment.…”

Section: 23mentioning

confidence: 99%

Multifunctional inorganic nanomaterials for cancer photoimmunotherapy

Tang

Zhang

et al. 2022

Cancer Communications

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Phototherapy and immunotherapy in combination is regarded as the ideal therapeutic modality to treat both primary and metastatic tumors. Immunotherapy uses different immunological approaches to stimulate the immune system to identify tumor cells for targeted elimination. Phototherapy destroys the primary tumors by light irradiation, which induces a series of immune responses through triggering immunogenic cancer cell death. Therefore, when integrating immunotherapy with phototherapy, a novel anti-cancer strategy called photoimmunotherapy (PIT) is emerging. This synergistic treatment modality can not only enhance the effectiveness of both therapies but also overcome their inherent limitations, opening a new era for the current anti-cancer therapy. Recently, the advancement of nanomaterials affords a platform for PIT. From all these nanomaterials, inorganic nanomaterials stand out as ideal mediators in PIT due to their unique physiochemical properties. Inorganic nanomaterials can not only serve as carriers to transport immunomodulatory agents in immunotherapy owing to their excellent drug-loading capacity but also function as photothermal agents or photosensitizers in phototherapy because of their great optical characteristics. In this review, the recent advances of multifunctional inorganic nanomaterial-mediated drug delivery and their contributions to cancer PIT will be highlighted.

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“…In recent years, a series of PA-imaging CAs have been developed to improve imaging performance in biomedical applications. For example, biodegradable layered double hydroxide (LDH)-copper sulfide (CuS) nanocomposites were successfully prepared for PA imaging of breast cancer (Figure 1b; Liu, Tang, et al, 2020). Due to the high photothermal conversion efficiency, LDH-CuS NCs not only worked as CAs for PA imaging but also as photothermal agents for PTT under 808-nm laser irradiation.…”

Section: Cu-based Nms Used For Cancer Imagingmentioning

confidence: 99%

Copper‐based nanomaterials for cancer theranostics

Zhong

Wang

Qian

et al. 2022

WIREs Nanomed Nanobiotechnol

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Copper‐based nanomaterials (Cu‐based NMs) with favorable biocompatibility and unique properties have attracted the attention of many biomedical researchers. Cu‐based NMs are one of the most widely studied materials in cancer treatment. In recent years, great progress has been made in the field of biomedicine, especially in the treatment and diagnosis of tumors. This review begins with the classification of Cu‐based NMs and the recent synthetic strategies of Cu‐based NMs. Then, according to the abundant and special properties of Cu‐based NMs, their application in biomedicine is summarized in detail. For biomedical imaging, such as photoacoustic imaging, positron emission tomography imaging, and multimodal imaging based on Cu‐based NMs are summarized, as well as strategies to improve the diagnostic effectiveness. Moreover, a series of unique structures and functions as well as the underlying property activity relationship of Cu‐based NMs were shown to highlight their promising therapeutic performance. Cu‐based NMs have been widely used in monotherapies, such as photothermal therapy (PTT) and chemodynamic therapy (CDT). Moreover, the sophisticated design in composition, structure, and surface fabrication of Cu‐based NMs can endow these NMs with more modalities in cancer diagnosis and therapy. To further improve the efficiency of cancer treatment, combined therapy based on Cu‐based NMs was introduced in detail. Finally, the challenges, critical factors, and future prospects for the clinical translation of Cu‐based NMs as multifunctional theranostic agents were also considered and discussed. The aim of this review is to provide a better understanding and key consideration for the rational design of this increasingly important new paradigm of Cu‐based NMs as theranostic agents. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging

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Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites

Cited by 48 publications

References 42 publications

Synergistic Cancer Photochemotherapy via Layered Double Hydroxide-Based Trimodal Nanomedicine at Very Low Therapeutic Doses

Synergistic Cancer Photochemotherapy via Layered Double Hydroxide-Based Trimodal Nanomedicine at Very Low Therapeutic Doses

Multifunctional inorganic nanomaterials for cancer photoimmunotherapy

Copper‐based nanomaterials for cancer theranostics

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