Near-Infrared Autofluorescence in Bilateral Diffuse Uveal Melanocytic Proliferation Associated With Esophageal Carcinoma and Choroidal Metastasis

Golshahi, Azadeh; Bornfeld, Norbert; Weinitz, Silke; Kellner, Ulrich

doi:10.1097/icb.0000000000000244

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…AF has been used several times already in visualizing BDUMP. 2 , 3 , 9 , 10 Our results also demonstrate and emphasize the ease with which AF can be used for diagnosis. We encourage an update to the diagnostic criteria wherein AF replace fluorescein angiography as the standard for appreciating the giraffe-pattern in BDUMP.…”

Section: Discussionsupporting

confidence: 57%

Diagnostic evaluation of optical coherence tomography angiography and fundus autofluorescence in bilateral diffuse uveal melanocytic proliferation

Shiraki

Winegarner

Hashida

et al. 2018

American Journal of Ophthalmology Case Reports

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PurposeTo demonstrate the utility of optical coherence tomography angiography (OCTA) in visualizing the choroidal vasculature in bilateral diffuse uveal melanocytic proliferation (BDUMP), so as to elucidate pathophysiology and also aid in diagnosis. Additionally, to recommend autofluorescence (AF) over traditional angiography for purposes of noninvasive diagnosis.ObservationsThree BDUMP cases are examined using AF, and two are examined using OCTA. Additionally, the cases vary in etiology and include a case with iris cysts, which we believe to have only been recorded once before in scientific literature, steroids were successfully used to treat two cases and anti-tumor drugs were used to treat the third case. OCTA revealed altered choroidal vasculature in the two cases tested, and AF was successfully used to diagnose all three cases regardless of etiology.Conclusions and importanceWe believe the OCTA findings are potentially elucidative regarding the pathophysiology at the choroidal layer, where BDUMP lesions primarily exist. Given the limited number of recorded BDUMP cases and relatively unknown pathophysiology, OCTA may prove to be invaluable in visualizing disease progression. Also we were able to use AF to diagnose all three cases ranging from extremely rare iris cysts to a more conventional presentation, indicating its utility regardless of etiology.

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Section: Discussionsupporting

confidence: 57%

Diagnostic evaluation of optical coherence tomography angiography and fundus autofluorescence in bilateral diffuse uveal melanocytic proliferation

Shiraki

Winegarner

Hashida

et al. 2018

American Journal of Ophthalmology Case Reports

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“…A recent study found multifocal ERG amplitudes within the lower reference range, recorded in the less affected eye of a patient with no exudative retinal detachment and normal autofluorescence, (Golshahi et al. ). The authors also reported patchy lesions in the same eye on near‐infrared autofluorescence.…”

Section: Diagnosismentioning

confidence: 98%

Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

Klemp

Kiilgaard

Heegaard

et al. 2017

Acta Ophthalmologica

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Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.

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“… 2 , 7 , 8 , 9 Only 4% of uveal metastases arise from the gastrointestinal tract, and only a small percentage of these originate in the esophagus. 6 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 Furthermore, most reported cases of esophageal cancer metastasizing to the uvea are of squamous histology. Only a few cases of uveal metastases from adenocarcinoma of the esophagus have been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

A rare presentation of choroidal metastasis from primary esophageal adenocarcinoma successfully treated with intensity-modulated radiation therapy

Date

Adams

Teh

et al. 2018

American Journal of Ophthalmology Case Reports

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PurposeIn this case report, we present a case of choroidal metastasis from a primary esophageal adenocarcinoma that was treated successfully with intensity-modulated radiation therapy.ObservationsA 65-year-old male with known stage IV esophageal adenocarcinoma presented with a central scotoma in his left eye and was ultimately found to have a large choroidal metastatic lesion with overlying subretinal fluid. IMRT was administered over the course of four weeks, resulting in restoration of the patient's vision, regression of the metastatic lesion, and resolution of the subretinal fluid. As of 16 months following completion of radiation, there remains no evidence of choroidal recurrence or radiation-associated ocular complications.Conclusionsand Importance: To our knowledge, this is the first published case report of a choroidal metastasis from esophageal cancer responding durably to IMRT. IMRT should therefore be considered a viable treatment option for this rare disease.

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Near-Infrared Autofluorescence in Bilateral Diffuse Uveal Melanocytic Proliferation Associated With Esophageal Carcinoma and Choroidal Metastasis

Abstract: Bilateral diffuse uveal melanocytic proliferation can be associated with esophageal carcinoma as a systemic malignancy. Near-infrared imaging can be helpful to detect early stages of BDUMP and can help offer recently reported treatment options at an early stage of disease.

Cited by 9 publications

References 24 publications

Diagnostic evaluation of optical coherence tomography angiography and fundus autofluorescence in bilateral diffuse uveal melanocytic proliferation

Diagnostic evaluation of optical coherence tomography angiography and fundus autofluorescence in bilateral diffuse uveal melanocytic proliferation

Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

A rare presentation of choroidal metastasis from primary esophageal adenocarcinoma successfully treated with intensity-modulated radiation therapy

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