Near-infrared cyanine-based fluorescent probe: Rapidly visualizing the in situ release of hydrazine in living cells and zebrafish

Cui, Yali; Xu, Chenggong; Wu, Tian; Nie, Yamin; Zhou, Yanmei

doi:10.1016/j.snb.2021.130878

Cited by 20 publications

(1 citation statement)

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“…It is also used as a raw material for drugs, pesticides, dyes, foaming agents, contrast agents, antioxidants, and foaming agents ( Zhang et al, 2020b ). Despite its wide industrial applications, hydrazine is highly toxic and carcinogenic ( Chen et al, 2021 ; Cui et al, 2022 ). Although not endogenous, trace spills during use or transportation can pollute the environment and enter the body by inhalation or skin contact, causing respiratory and neurological harm, including eye and skin irritation, liver, kidney, and central nervous system damage ( Zhang et al, 2020a ).…”

Section: Introductionmentioning

confidence: 99%

An ICT-Based Coumarin Fluorescent Probe for the Detection of Hydrazine and Its Application in Environmental Water Samples and Organisms

Liu

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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As an inorganic small molecule pollutant, the toxicity and potential carcinogenicity of hydrazine (N2H4) are of increasing concern. In this work, A water-soluble fluorescent probe (OCYB) based on the intramolecular charge transfer (ICT) mechanism for the detection of hydrazine was designed and synthesized. Taking the advantage of 4-bromobutyryl as the recognition group, the high selectivity of OCYB to N2H4 was confirmed by steady-state fluorescence spectroscopy. The limit of detection (LOD) was calculated to be 78 nM in the DMSO-HEPES (pH 7.4) system. The detection mechanism was verified by NMR, HRMS and density functional theory (DFT) calculations. In addition, OCYB exhibits strong anti-interference ability and an “Off-On” fluorescence enhancement effect. Importantly, OCYB can be used to effectively monitor the fluorescence distribution of N2H4 in environmental water samples and organisms.

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