Near Infrared Emissive Lanthanide Luminescence Nanoparticle Used in Early Diagnosis and Brain Temperature Detection for Ischemic Stroke

Abstract

Ischemic stroke (IS) is one of the most dangerous diseases resulting in high mortality and morbidity. The increased brain temperature after IS is closely related to prognosis, making it highly significant to the early diagnosis and the progression evaluation of IS. Herein, a temperature‐responsive near infrared (NIR) emissive lanthanide luminescence nanoparticle is developed for the early diagnosis and brain temperature detection of IS. After intravenous injection, the nanoparticles can pass through the damaged blood‐brain barrier of the ischemic region, allowing the extravasation and enrichment of nanoparticles into the ischemic brain tissue. The NIR luminescence signals of the nanoparticles are used not only to judge the location and severity of the cerebral ischemic injury but also to report the brain temperature variation in the ischemic area through a visualized way. The results show that the designed nanoparticles can be used for the early diagnosis of ischemic stroke and minimally invasive temperature detection of cerebral ischemic tissues in transient middle cerebral artery occlusion mice model, which is expected to make the clinical diagnosis of ischemic stroke more rapid and convenient, more accurately evaluate the state of brain injury in stroke patients and also guide stroke hypothermia treatment.This article is protected by copyright. All rights reserved

Nanothermometry for cellular temperature monitoring and disease diagnostics

“…127,128 Zhu et al solved this problem using temperature-responsive NIR emitting lanthanide luminescent nanoparticles. 129 Brain temperatures are higher than in unaffected areas and the body due to the ischemic metabolic response, the impairment of brain heat exchange function caused by changes in cerebral blood flow, and the activity of early inflammatory cells. Therefore, the temperature in the brain can be used as an indicator of ischemic stroke for early diagnosis and disease tracking.…”

Photoresponsive lanthanide luminescent materials

“…Additionally, Pr 3+ , Nd 3+ , Dy 3+ , Ho 3+ , Er 3+ , Tm 3+ , and Yb 3+ all emit radiation in near-infrared (NIR) light. [14][15][16] The emission spectra of Ln 3+ ions cover a wide range, including the ultraviolet (UV), visible (400-800 nm), and NIR (800-1700 nm) regions, which are widely recognized as valuable emitting sources. 17,18 Due to the shielding effect of the partially filled 4f shell by the closed 5s 2 and 5p 6 shells, the emission a School of Chemical Engineering and Technology, Hebei University of Technology, GuangRong Dao 8, Hongqiao District, Tianjin 300130, P. R. China.…”