Near-infrared estimation of O2 supply and consumption in forearm muscles working at varying intensity

Homma, Shunsaku; Eda, Hideo; Ogasawara, S; Kagaya, Atsuko

doi:10.1152/jappl.1996.80.4.1279

Cited by 114 publications

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“…The measurement is intermittent and yields one value per venous occlusion. However, the values are likely to be reproducible even if measured on different days (44,50). The spatial resolution is on the order of 1 cm and is two-dimensional.…”

Section: Limitations Potential Clinical Applications and Outlookmentioning

confidence: 97%

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Regional Differences of Hemodynamics and Oxygenation in the Human Calf Muscle Detected with Near-Infrared Spectrophotometry

Wolf¹,

Wolf²,

Choi³

et al. 2007

Journal of Vascular and Interventional Radiology

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PURPOSE: Measurements in muscle tissue are often performed at a selected single location over the muscle of interest. The hypothesis is that the values obtained reflect the status within the entire muscle or muscle group. This, however, may not be the case. The study was performed to investigate whether this hypothesis is true for hemodynamics and oxygenation in the healthy human calf muscle at rest. MATERIALS AND METHODS:Hemoglobin flow, blood flow, oxygen consumption, and venous hemoglobin oxygen saturation were mapped at 22 locations in 30 legs of 15 healthy subjects (nine women, six men aged 26 -37 years) simultaneously by using frequency-domain near-infrared spectrophotometry with a specially designed probe during venous occlusion. RESULTS: For all parameters, spatial heterogeneity was found between subjects and within individual legs. All parameters were highly significantly different when comparing proximal and distal regions. Differences were also found between medial and lateral regions. The global mean values (؎standard deviation) over all measurements were as follows: hemoglobin flow, 1.27 mol per 100 mL/min ؎ 0.88; blood flow, 0.56 mL per 100 g/min ؎ 0.38; oxygen consumption, 0.016 mL per 100 g/min ؎ 0.011; and venous oxygen saturation, 77.6% ؎ 5.9. The thickness of the overlying adipose tissue had an influence on the measurements and must be considered. CONCLUSION: Highly significant spatial heterogeneity of hemodynamics and oxygenation was found in the healthy human calf muscle. J Vasc Interv Radiol 2007; 18:1094 -1101Abbreviations: ATT ϭ adipose tissue thickness, DPF ϭ differential pathlength factor, NIRS ϭ near-infrared spectrophotometry, SvO 2 ϭ venous oxygen saturation, TRV ϭ test-retest variability, VO 2 ϭ oxygen consumption NEAR-INFRARED spectrophotometry (NIRS) is a valuable tool for measuring hemodynamics and oxygenation in human tissue. NIRS is noninvasive, provides real-time measurements, is costeffective, is feasible at the bedside, and is easily repeatable and reproducible and, therefore, suitable for use in the clinical setting. Because NIRS provides measurements at the level of arterioles, capillaries, and venules (1) several centimeters deep in the tissue, it is a complementary method to Doppler, which probes larger blood vessels, laser Doppler flowmetry, which measures superficial blood vessels, and imaging techniques such as magnetic resonance (MR) imaging, positron emission tomography (PET), and radiography, which depend on the use of ionizing radiation and/or contrast media. NIRS has been applied to infants and adults to measure hemodynamics and oxygenation in many fields such as the brain, but one particularly promising field is the skeletal muscle (2-5). Studies in the skeletal muscle have included measurements in sports medicine (6,7) and in patients with peripheral vascular disease (8 -17), myopathies (18 -20), and heart failure (21-23).Measurements in muscle tissue are often performed at a selected single location over the muscle of interest. The values obtained are consider...

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Section: Limitations Potential Clinical Applications and Outlookmentioning

confidence: 97%

“…The measurements of SvO 2 (49) and blood flow (35,50) have also been validated against other methods.…”

Section: Precision and Trvmentioning

confidence: 99%

Regional Differences of Hemodynamics and Oxygenation in the Human Calf Muscle Detected with Near-Infrared Spectrophotometry

Wolf¹,

Wolf²,

Choi³

et al. 2007

Journal of Vascular and Interventional Radiology

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“…A previous study on stimulated canine muscle showed that intramuscular pressure gradient from the distal to the proximal portion of muscle was a major driving force pushing blood out of the muscle [5]. Homma et al [24] reported that NIR-blood volume determined by the ischemia technique could reflect blood flow. The index of NIR-blood volume should be sensitive to changes in intramuscular pressure, with increasing intramuscular pressure decreasing blood volume.…”

Section: Fig 3 Typical Changes For Nir-o 2 Saturation (Top)mentioning

confidence: 99%

Regional Difference of Muscle Oxygen Saturation and Blood Volume during Exercise Determined by Near Infrared Imaging Device.

Miura

McCully²,

Liang³

et al. 2001

JJP

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During exercise, the metabolic need for oxygen in muscles increases many times above the resting level. To meet this oxygen demand, oxygen supply to the contracting muscle must increase; this is accomplished by an increased cardiac output and a redistribution of the blood supply. During exercise, heteroJapanese Journal of Physiology Vol. 51, No. 5, 2001 599Japanese Journal of Physiology, 51, 599-606, 2001 Key words: near infrared light, imaging, oxygen saturation, blood volume, heterogeneity.Abstract: Using a near infrared (NIR) imaging device, we tested the hypothesis that regional differences in oxygen status could be detected in the gastrocnemius muscle during exercise and recovery. Six healthy subjects performed the standing plantar flexion exercises for 2 min; the frequency was one contraction per second. The NIR imaging device was placed over the medial head of the right gastrocnemius muscle and the signals from two optical sensors situated on the middle proximal and middle distal portions were used. The NIR-O 2 saturation (difference between deoxygenated and oxygenated Hb signals) and NIR-blood volume (sum of the oxygenated and deoxygenated Hb signals) were calculated in optical density units. Plantar flexion resulted in more deoxygenation during exercise and more reoxygenation during recovery in the distal portion compared with the proximal portion. The changes in NIR-O 2 between rest and a 2 min exercise, and between a 2 min exercise and a 3 min recovery were 0.11 and Ϫ0.23, respectively, in the distal portion, which were significantly larger than proximal values (0.05 and Ϫ0.10, pϽ0.05). Plantar flexion resulted in lower NIR-blood volumes during exercise and greater recovery of blood after exercise in the distal portion compared with the proximal portion. The changes in NIR blood volume between rest and a 2 min exercise and between a 2 min exercise and a 3 min recovery were Ϫ0.19 and 0.31, respectively, in the distal portion, significantly larger than proximal values (Ϫ0.07 and 0.12, pϽ0.05 for all comparisons). These findings indicate that the distal portion of the medial gastrocnemius had larger changes in NIR-O 2 saturation and NIR-blood volume than the proximal portion had. This is consistent with the distal portion having a greater impairment of blood flow possibly because of the higher intramuscular pressure during exercise. In conclusion: (1) regional differences in oxygen status in the gastrocnemius muscle were detected with exercise, with the distal portion having greater NIR-O 2 saturation and NIR-blood volume changes, and (2) the NIR imaging device might be a useful method to detect the regional differences of oxygen status in the muscle.

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“…However, blood sampling is invasive and requires a high precision. The widely used indirect measure of muscle blood flow is strain-gauge plethysmography 21,32,33) . However, with this method, it is impossible to measure absolute values (i.e., ml/min/100 g tissue) during moderate to strenuous exercise.…”

Section: Discussionmentioning

confidence: 99%

“…The reducibility of forearm blood flow during rest using the venous occlusion method has proved to be reliable within test sessions, although the mean values of the within-subject variability varied by between 10 and 29% 21,23,24) . NIRS blood flows for resting and post-exercise s h o w g o o d a g r e e m e n t w i t h s t r a i n -g a u g e plethysmography 21,32) , although flow measured by plethysmography is generally two to three times higher than the NIRS flow 21,24) . On the other hand, VO 2NIRS using arterial occlusion can be calculated from the rate of decrease in OxyHb [37][38][39][40] or from the rate of decrease in Hbdiff, reflecting the difference between oxyand deoxyhaemoglobin (Hbdiff) 2 0, 22 -2 4, 37 ) .…”

Section: Discussionmentioning

confidence: 99%

Muscle Blood Flow and Oxygen Utilization Measured by Near-Infrared Spectroscopy during Handgrip Exercise in Chronic Respiratory Patients

Sekikawa

Tabira

Sekikawa³

et al. 2009

J Phys Ther Sci

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Abstract.[Purpose] The purpose of this study was to evaluate tissue oxygen utilization and blood flow in patients with chronic respiratory failure (CRF).[Subjects] The subjects were divided into three groups: twelve subjects with chronic respiratory failure, twelve healthy older subjects, and thirteen healthy young subjects.[Method] A near infrared spectrometer was used to monitor tissue oxygenation, and the probe was placed over the flexor muscle. The subjects performed 3min rhythmic handgrip (HG) exercise at 10 and 30% of maximum voluntary contraction force in a random order. Forearm blood flow was estimated by the rate of increase in the sum of oxy-hemoglobin (OxyHb) and deoxy-hemoglobin (DeoxyHb) during venous occlusion, and muscle oxygen utilization by the rate of decrease in the difference between OxyHb and DeoxyHb during arterial occlusion.[Results] Forearm blood flow in the CRF group was significantly lower compared to the older group during 10% HG and the younger group in 30% HG. Muscle oxygen utilization in the CRF group was significantly higher than the older and young groups in 10% HG.[Conclusion]We conclude that the CRF patients desaturate their muscles more than normal control subjects at a lower work level due to insufficiency of blood flow to the exercising muscles.

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Near-infrared estimation of O2 supply and consumption in forearm muscles working at varying intensity

Cited by 114 publications

References 0 publications

Regional Differences of Hemodynamics and Oxygenation in the Human Calf Muscle Detected with Near-Infrared Spectrophotometry

Regional Differences of Hemodynamics and Oxygenation in the Human Calf Muscle Detected with Near-Infrared Spectrophotometry

Regional Difference of Muscle Oxygen Saturation and Blood Volume during Exercise Determined by Near Infrared Imaging Device.

Muscle Blood Flow and Oxygen Utilization Measured by Near-Infrared Spectroscopy during Handgrip Exercise in Chronic Respiratory Patients

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