Near-infrared fluorescence cholangiography assisted laparoscopic cholecystectomy versus conventional laparoscopic cholecystectomy (FALCON trial): study protocol for a multicentre randomised controlled trial

Bos, Jacqueline van den; Schols, Rutger M.; Luyer, Misha; Dam, Ronald M. van; Vahrmeijer, Alexander L.; Meijerink, W. J. H. J.; Gobardhan, Paul D.; Dam, Gooitzen M. van; Bouvy, Nicole D.; Stassen, Laurents P. S.

doi:10.1136/bmjopen-2016-011668

Cited by 45 publications

(24 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Apart from the above mentioned ZW-800, other new preclinical dyes such as VM678, IRDye®800CW, IRDye®800BK and IRDye®800NOS have been tested in animals and show very promising results [ 24 , 65 ]. These are due to better pharmacokinetic characteristics and target-to-background ratio of these dyes [ 24 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Optimizing the image of fluorescence cholangiography using ICG: a systematic review and ex vivo experiments

et al. 2018

Self Cite

View full text Add to dashboard Cite

BackgroundThough often only briefly described in the literature, there are clearly factors that have an influence on the fluorescence intensity, and thereby the usefulness of the technique. This article aims to provide an overview of the factors influencing the fluorescence intensity of fluorescence imaging with Indocyanine green, primarily focussed on NIRF guided cholangiography.MethodsA systematic search was conducted to gain an overview of currently used methods in NIRF imaging in laparoscopic cholecystectomies. Relevant literature was searched to gain advice on what methods to use. Ex vivo experiments were performed to assess various factors that influence fluorescence intensity and whether the found clinical advices can be confirmed.ResultsICG is currently the most widely applied fluorescent dye. Optimal ICG concentration lies between 0.00195 and 0.025 mg/ml, and this dose should be given as early as achievable—but maximum 24 h—before surgery. When holding the laparoscope closer and perpendicular to the dye, the signal is most intense. In patients with a higher BMI and/or cholecystitis, fluorescence intensity is lower, but NIRF seems to be more helpful. There are differences between various marketed fluorescence systems. Also, no uniform method to assess fluorescence intensity is available yet.ConclusionsThis study identified and discussed several factors that influence the signal of fluorescence cholangiography. These factors should be taken into account when using NIRF cholangiography. Also, surgeons should be aware of new dyes and clinical systems, in order to benefit most from the potential of NIRF imaging.Electronic supplementary materialThe online version of this article (10.1007/s00464-018-6233-x) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The IRDyes have the same spectral characteristics as ICG, which enables the use of the same equipment. IRDye®800CW is expensive, with a price tenfold that of ICG; IRDye®800BK and IRDye®800NOS however cost the same as ICG [ 65 ]. But these dyes are not yet FDA approved.…”

Section: Discussionmentioning

confidence: 99%

Optimizing the image of fluorescence cholangiography using ICG: a systematic review and ex vivo experiments

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…With the aim of overcoming the limits of retrospective data, a prospective randomized controlled trial (FALCON) was set up in 2016 to compare near-infrared fluorescence cholangiography-assisted laparoscopic cholecystectomy versus conventional laparoscopic cholecystectomy. The results are expected in 2 years[ 26 ].…”

Section: Biliary Anatomymentioning

confidence: 96%

Indocyanine green-based fluorescence imaging in visceral and hepatobiliary and pancreatic surgery: State of the art and future directions

Baiocchi

Diana

Boni

2018

WJG

106

View full text Add to dashboard Cite

In recent years, the use of fluorescence-guided surgery (FGS) to treat benign and malignant visceral, hepatobiliary and pancreatic neoplasms has significantly increased. FGS relies on the fluorescence signal emitted by injected substances (fluorophores) after being illuminated by ad hoc laser sources to help guide the surgical procedure and provide the surgeon with real-time visualization of the fluorescent structures of interest that would be otherwise invisible. This review surveys and discusses the most common and emerging clinical applications of indocyanine green (ICG)-based fluorescence in visceral, hepatobiliary and pancreatic surgery. The analysis, findings, and discussion presented here rely on the authors’ significant experience with this technique in their medical institutions, an up-to-date review of the most relevant articles published on this topic between 2014 and 2018, and lengthy discussions with key opinion leaders in the field during recent conferences and congresses. For each application, the benefits and limitations of this technique, as well as applicable future directions, are described. The imaging of fluorescence emitted by ICG is a simple, fast, relatively inexpensive, and harmless tool with numerous different applications in surgery for both neoplasms and benign pathologies of the visceral and hepatobiliary systems. The ever-increasing availability of visual systems that can utilize this tool will transform some of these applications into the standard of care in the near future. Further studies are needed to evaluate the strengths and weaknesses of each application of ICG-based fluorescence imaging in abdominal surgery.

show abstract

“…Die spezielle Kameratechnik ist bisher in den wenigsten Kliniken verfügbar und lässt sich in älteren Systemen nahezu nicht nachrüsten. Zudem ist ICG als Substanz selbst relativ teuer [12].…”

Section: Stellenwertunclassified

Anatomische Varianten des Leberhilus

Tautenhahn¹,

Settmacher²,

Zanow³

2019

Allgemein- und Viszeralchirurgie up2date

View full text Add to dashboard Cite

Near-infrared fluorescence cholangiography assisted laparoscopic cholecystectomy versus conventional laparoscopic cholecystectomy (FALCON trial): study protocol for a multicentre randomised controlled trial

Abstract: To cite: van den Bos J, Schols RM, Luyer MD, et al. Near-infrared fluorescence cholangiography assisted laparoscopic cholecystectomy versus conventional laparoscopic cholecystectomy (FALCON trial): study protocol for a multicentre randomised controlled trial.

Cited by 45 publications

References 43 publications

Optimizing the image of fluorescence cholangiography using ICG: a systematic review and ex vivo experiments

Optimizing the image of fluorescence cholangiography using ICG: a systematic review and ex vivo experiments

Indocyanine green-based fluorescence imaging in visceral and hepatobiliary and pancreatic surgery: State of the art and future directions

Anatomische Varianten des Leberhilus

Contact Info

Product

Resources

About