Near-Infrared Fluorescence from Nanodiamond for Multimodal Bioimaging

Lin, Ying; Tsai, Lin Wei; Perevedentseva, E.; Karmenyan, Artashes; Cheng, Chia‐Liang

doi:10.17691/stm2018.10.1.06

Cited by 4 publications

(9 citation statements)

References 18 publications

(30 reference statements)

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“…This signal was registered in the spectroscopic range of 450–650 nm, including the emission of H 3 , NV 0 , particularly NV − and some other centers [62]. Note, that the two-photon excitation of fluorescence of NV − and NV 0 [67] and Ni-related 1.4 eV [68] centers has been demonstrated earlier. The measured lifetime of the 100 ND used was short, less than 1 ns (Figure 2c), and allows distinguishing with endogenous fluorophores (the bio-sample autofluorescence) and many exogenous fluorophores, which can be observed or used in bio-imaging.…”

Section: Resultsmentioning

confidence: 69%

Optical Studies of Nanodiamond-Tissue Interaction: Skin Penetration and Localization

et al. 2019

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In this work, several optical-spectroscopic methods have been used to visualize and investigate the penetration of diamond nanoparticles (NPs) of various sizes (3–150 nm), surface structures and fluorescence properties into the animal skin in vitro. Murine skin samples have been treated with nanodiamond (ND) water suspensions and studied using optical coherence tomography (OCT), confocal and two-photon fluorescence microscopy and fluorescence lifetime imaging (FLIM). An analysis of the optical properties of the used nanodiamonds (NDs) enables the selection of optimal optical methods or their combination for the study of nanodiamond–skin interaction. Among studied NDs, particles of 100 nm in nominal size were shown to be appropriate for multimodal imaging using all three methods. All the applied NDs were able to cross the skin barrier and penetrate the different layers of the epidermis to finally arrive in the hair follicle niches. The results suggest that NDs have the potential for multifunctional applications utilizing multimodal imaging.

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Section: Resultsmentioning

confidence: 69%

Optical Studies of Nanodiamond-Tissue Interaction: Skin Penetration and Localization

et al. 2019

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“…Emission in the range of 470–550 nm is presumably associated with N3, H4, and the Ni‐related W8 defect with a ZPL at 484 nm (2.56 eV). [ 21 ] The dominant feature in the luminescence is the line with a maximum at a wavelength of about 880 nm (1.4 eV Ni center). At 79 K, the 883 and 885 nm doublet is clearly visible (see Figure S1, Supporting Information) and being indistinguishable at room temperature.…”

Section: Resultsmentioning

confidence: 99%

“…[ 20 ] The exact position of the 1.4 eV Ni lines varies for different diamonds and is determined by the strain in the sample. [ 21 ] These defects can be found in both natural and synthetic diamonds. The appearance of Ni centers in the crystal structure of the latter is associated with the use of nickel catalysts in diamond growth.…”

Section: Introductionmentioning

confidence: 99%

Nickel‐Related Centers in HPHT Microdiamonds for Near‐Infrared Luminescent Thermometry

Kurochkin,

Sychev,

Gritsienko

et al. 2023

Physica Rapid Research Ltrs

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Nano‐ and microcrystals of diamond are attractive for optical thermometry applications and possess unique optical properties as well as high chemical stability and biocompatibility. For biological application, there are interests of diamonds with color centers that emit in the biological transparency window. One such defect is nickel‐related color centers that radiate in the near‐infrared range (1.4 eV Ni centers), but have not yet been sufficiently investigated. In this study, the optical characteristics of high‐pressure high‐temperature (HPHT) diamond microcrystals with average sizes of 4 and 30 μm containing 1.4 eV Ni centers are reported. The temperature dependence of the spectral and temporal properties of Ni center emissions in the range from room temperature to 85 °C is demonstrated and thereby the possibility of appliance these centers as temperature sensors. The relative temperature sensitivities of luminescence peak intensity and lifetime for Ni centers are found to be 1.3% K−1 and 0.42% K−1, respectively. Moreover, the temperature determination accuracy reaches better than 1 K.

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“…In general, photoluminescence spectra are obtained by excitation of fluorescent molecules with different wavelengths of laser light [ 22 ]. NDs have abundant optical color center defects, with zero-phonon lines at 575 nm and 637 nm for NV centers, 738 nm for SiV centers, and 883 nm and 885 nm for nickel-related centers, respectively [ 5 ]. The zero-phonon line of NDs’ optical color centers has a characteristic peak in the photoluminescence spectrum, which allows the analysis of the photoluminescence spectrum to identify what type of vacancy defects are present in the NDs.…”

Section: Fluorescence Imagingmentioning

confidence: 99%

“…The emission spectra of NDs’ NV center reflects the interactions on the nanodiamond surface and the number of NV centers inside the particles [ 3 ]. NV centers exist mainly in neutral and negative charge states, and their broad-spectrum stable emission at room temperature makes them widely used in bioimaging [ 5 ]. However, the excitation wavelength of NV centers is usually in the range of 510–560 nm, making it easily absorbed by organic molecules, causing problems of tissue autofluorescence interference and low tissue penetration depth.…”

Section: Introductionmentioning

confidence: 99%

Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review

Wang,

Sang,

Zou

et al. 2023

Molecules

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Nanodiamonds (NDs) are emerging as a promising candidate for multimodal bioimaging on account of their optical and spectroscopic properties. NDs are extensively utilized for bioimaging probes due to their defects and admixtures in their crystal lattice. There are many optically active defects presented in NDs called color centers, which are highly photostable, extremely sensitive to bioimaging, and capable of electron leap in the forbidden band; further, they absorb or emit light when leaping, enabling the nanodiamond to fluoresce. Fluorescent imaging plays a significant role in bioscience research, but traditional fluorescent dyes have some drawbacks in physical, optical and toxicity aspects. As a novel fluorescent labeling tool, NDs have become the focus of research in the field of biomarkers in recent years because of their various irreplaceable advantages. This review primarily focuses on the recent application progress of nanodiamonds in the field of bioimaging. In this paper, we will summarize the progress of ND research from the following aspects (including fluorescence imaging, Raman imaging, X-ray imaging, magnetic modulation fluorescence imaging, magnetic resonance imaging, cathodoluminescence imaging, and optical coherence tomography imaging) and expect to supply an outlook contribution for future nanodiamond exploration in bioimaging.

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Near-Infrared Fluorescence from Nanodiamond for Multimodal Bioimaging

Cited by 4 publications

References 18 publications

Optical Studies of Nanodiamond-Tissue Interaction: Skin Penetration and Localization

Optical Studies of Nanodiamond-Tissue Interaction: Skin Penetration and Localization

Nickel‐Related Centers in HPHT Microdiamonds for Near‐Infrared Luminescent Thermometry

Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review

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