Near-infrared fluorescence molecular endoscopy detects dysplastic oesophageal lesions using topical and systemic tracer of vascular endothelial growth factor A

Nagengast, Wouter B.; Hartmans, Elmire; García-Allende, P. Beatriz; Peters, Frans; Linssen, Matthijs D.; Koch, Maximilian; Koller, Marjory; Tjalma, Jolien J.; Karrenbeld, Arend; Jorritsma-Smit, Annelies; Kleibeuker, Jan H.; Dam, Gooitzen M. van; Ntziachristos, Vasilis

doi:10.1136/gutjnl-2017-314953

Cited by 97 publications

(110 citation statements)

References 22 publications

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“…This is partly caused by concurrent white light and fluorescence endoscopy in the visible light spectrum, which limits the sensitivity and contrast because of endogenous auto-fluorescence. Nagengast et al 57 evaluated the monoclonal antibody bevacizumab targeting vascular endothelial growth factor A labeled to a NIR fluorophore, CW800, for dysplasia detection after both i.v. and topical administration.…”

Section: Detection Of Dysplasia In Barrett Esophagusmentioning

confidence: 99%

Novel Developments in Endoscopic Mucosal Imaging

2018

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Endoscopic techniques such as high-definition and optical-chromoendoscopy have had enormous impact on endoscopy practice. Since these techniques allow assessment of most subtle morphological mucosal abnormalities, further improvements in endoscopic practice lay in increasing the detection efficacy of endoscopists. Several new developments could assist in this. First, web based training tools could improve the skills of the endoscopist for enhancing the detection and classification of lesions. Secondly, incorporation of computer aided detection will be the next step to raise endoscopic quality of the captured data. These systems will aid the endoscopist in interpreting the increasing amount of visual information in endoscopic images providing real-time objective second reading. In addition, developments in the field of molecular imaging open opportunities to add functional imaging data, visualizing biological parameters, of the gastrointestinal tract to white-light morphology imaging. For the successful implementation of abovementioned techniques, a true multi-disciplinary approach is of vital importance.

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Section: Detection Of Dysplasia In Barrett Esophagusmentioning

confidence: 99%

Novel Developments in Endoscopic Mucosal Imaging

2018

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“…As mentioned before, using the TASC scoring system, seven potential targets for optical molecular imaging of PC of colorectal origin have been identified: CXCR4, EpCAM, EGFR, CEA, Muc1, MMPs, and VEGF‐A . The specifics of these proteins and receptors are summarized in Table . Several fluorescent imaging probes targeting these biomarkers have already been investigated in humans in a broad variety of indications.…”

Section: Potential Fluorescence Imaging Agents For Detection Of Colormentioning

confidence: 99%

Molecular fluorescence‐guided surgery of peritoneal carcinomatosis of colorectal origin: A narrative review

Hentzen

Jongh

Hemmer

et al. 2018

Journal of Surgical Oncology

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Patients with peritoneal carcinomatosis (PC) from colorectal origin may undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as a curative approach. One major prognostic factor that affects survival is completeness of cytoreduction. Molecular Fluorescence Guided Surgery (MFGS) is a novel intraoperative imaging technique that may improve tumor identification in the future, potentially preventing over‐ and under‐treatment in these patients. This narrative review outlines a chronological overview of MFGS development in patients with PC of colorectal origin.

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“…Due to the complicated surgical anatomy in the head and neck region and the presence of the crucial structures, such as carotid arteries and cranial nerves, 15%-30% of patients will have a positive margin upon final histopathology; a rate that has not changed over the last 30 years despite many novel surgical techniques. [9][10][11][12][13][14][15] In head and neck squamous cell carcinoma (HNSCC), the epidermal growth factor receptor (EGFR) is overexpressed in >90% of tumor cells, making it ideal for optical targeted imaging. [4][5][6][7] Accurate sampling of tissue samples to confirm adequate resection is crucial for this technique to be effective.…”

Section: Introductionmentioning

confidence: 99%

“…8 To improve surgical outcome and margin assessment accuracy, tumor-specific antibody-based fluorescence imaging has been proposed to achieve demarcation and differentiation of cancerous from healthy adjacent tissue. [9][10][11][12][13][14][15] In head and neck squamous cell carcinoma (HNSCC), the epidermal growth factor receptor (EGFR) is overexpressed in >90% of tumor cells, making it ideal for optical targeted imaging. 16 We have previously demonstrated that our near-infrared fluorescently labeled anti-EGFR antibody, panitumumab-IRDye800CW, is highly sensitive and specific for HNSCC.…”

Section: Introductionmentioning

confidence: 99%

Probe‐based fluorescence dosimetry of an antibody‐dye conjugate to identify head and neck cancer as a first step to fluorescence‐guided tissue preselection for pathological assessment

et al. 2019

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Background Despite the rapid growth of fluorescence imaging, accurate sampling of tissue sections remains challenging. Development of novel technologies to improve intraoperative assessment of tissue is needed. Methods A novel contact probe‐based fluorescence dosimeter device, optimized for IRDye800CW quantification, was developed. After evaluation of the device in a phantom setup, its clinical value was defined ex vivo in patients with head and neck squamous cell carcinoma who received panitumumab‐IRDye800CW. Results Ten patients were enrolled with a total of 216 data points obtained. Final histopathology showed tumor in 119 spots and normal tissue in 97 spots. Fluorescence‐to‐excitation ratios in tumor tissue were more than three times higher than those in normal tissue. The area under the curve was 0.86 (95% CI: 0.81‐0.91) for tumor detection. Conclusions Fluorescence‐guided tissue preselection using a fluorescence dosimeter could have substantial impact on tissue sampling for frozen section analysis and potentially reduce sampling errors.

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Near-infrared fluorescence molecular endoscopy detects dysplastic oesophageal lesions using topical and systemic tracer of vascular endothelial growth factor A

Cited by 97 publications

References 22 publications

Novel Developments in Endoscopic Mucosal Imaging

Novel Developments in Endoscopic Mucosal Imaging

Molecular fluorescence‐guided surgery of peritoneal carcinomatosis of colorectal origin: A narrative review

Probe‐based fluorescence dosimetry of an antibody‐dye conjugate to identify head and neck cancer as a first step to fluorescence‐guided tissue preselection for pathological assessment

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