Near-infrared-II activated inorganic photothermal nanomedicines

Yu, Zhongzheng; Chan, W.K.; Zhang, Yan; Tan, Timothy Thatt Yang

doi:10.1016/j.biomaterials.2020.120459

Cited by 113 publications

(74 citation statements)

References 118 publications

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“…Compared to the visible range, where the auto-fluorescence of most tissue components is located, the near-infrared (NIR) range generally exhibits better spatial resolution and sharper contrast ( Kenry et al, 2018 ). Recent studies have demonstrated that probes utilized in biological window II (1000–1700 nm, NIR-II) work more effectively than that in biological window I (700–900 nm, NIR-I) ( He et al, 2015 ; Zhong et al, 2017 ; Fan et al, 2018 ; Huang et al, 2020 ; Lin et al, 2021 ; Lv et al, 2021 ; Yu et al, 2021 ). However, most reports on NIR probes are realized in the first biological window ( Zhou et al, 2020a ).…”

Section: Introductionmentioning

confidence: 99%

NIR-II Upconversion Photoluminescence of Er3+ Doped LiYF4 and NaY(Gd)F4 Core-Shell Nanoparticles

Feng

Zheng

et al. 2021

Front. Chem.

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The availability of colloidal nano-materials with high efficiency, stability, and non-toxicity in the near infrared-II range is beneficial for biological diagnosis and therapy. Rare earth doped nanoparticles are ideal luminescent agents for bio-applications in the near infrared-II range due to the abundant energy level distribution. Among them, both excitation and emission range of Er3+ ions can be tuned into second biological window range. Herein, we report the synthesis of ∼15 nm LiYF4, NaYF4, and NaGdF4 nanoparticles doped with Er3+ ions and their core-shell structures. The luminescent properties are compared, showing that Er3+ ions with single-doped LiYF4 and NaYF4 nanoparticles generate stronger luminescence than Er3+ ions with doped NaGdF4, despite the difference in relative intensity at different regions. By epitaxial growth an inert homogeneous protective layer, the surface luminescence of the core-shell structure is further enhanced by about 5.1 times, 6.5 times, and 167.7 times for LiYF4, NaYF4, and NaGdF4, respectively. The excellent luminescence in both visible and NIR range of these core-shell nanoparticles makes them potential candidate for bio-applications.

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Section: Introductionmentioning

confidence: 99%

NIR-II Upconversion Photoluminescence of Er3+ Doped LiYF4 and NaY(Gd)F4 Core-Shell Nanoparticles

Feng

Zheng

et al. 2021

Front. Chem.

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“…Generally, PTAs in the near-infrared biowindows (NIR-I: 650-1000 nm and NIR-II: 1000-1700 nm), with the features of weak damage to tissues, low self-absorption and high tissue penetration, are suitable for tumor treatments [6][7][8]. According to the chemical composition of PTAs, they can be classified into two categories: organic and inorganic nanomaterials [9]. Organic PTAs are widely used in PTT and include small-molecule dyes and polymer-based nanoparticles (NPs).…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials and their composite scaffolds for photothermal therapy and tissue engineering applications

Sun

Chen

Sutrisno

et al. 2021

Science and Technology of Advanced Materials

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Photothermal therapy (PTT) has attracted broad attention as a promising method for cancer therapy with less severe side effects than conventional radiation therapy, chemotherapy and surgical resection. PTT relies on the photoconversion capacity of photothermal agents (PTAs), and a wide variety of nanomaterials have been employed as PTAs for cancer therapy due to their excellent photothermal properties. The PTAs are systematically or locally administered and become enriched in cancer cells to increase ablation efficiency. In recent years, PTAs and three-dimensional scaffolds have been hybridized to realize the local delivery of PTAs for the repeated ablation of cancer cells. Meanwhile, the composite scaffolds can stimulate the reconstruction and regeneration of the functional tissues and organs after ablation of cancer cells. A variety of composite scaffolds of photothermal nanomaterials have been prepared to combine the advantages of different modalities to maximize their therapeutic efficacy with minimal side effects. The synergistic effects make the composite scaffolds attractive for biomedical applications. This review summarizes these latest advances and discusses the future prospects.

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“…[4] However,i no rder to achieve complete tumor elimination, PTT needs to increase the cancerous tumors temperature over 50 8 8C. [5] Such high temperature could not only ablate the tumors but also damage normal tissues around lesions through heat diffusion. [6] To alleviate this problem, researchers have sought to utilize mild-temperature PTT (38-43 8 8C) to induce cancer cells death.…”

Section: Introductionmentioning

confidence: 99%

“…PTT usually utilizes photothermal conversion agents to convert light energy into hyperthermia, which subsequently kills cancer cells with high specificity and efficiency [4] . However, in order to achieve complete tumor elimination, PTT needs to increase the cancerous tumors temperature over 50 °C [5] . Such high temperature could not only ablate the tumors but also damage normal tissues around lesions through heat diffusion [6] .…”

Section: Introductionmentioning

confidence: 99%

Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

et al. 2021

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Photothermal therapy( PTT) is an extremely promising tumor therapeutic modality.H owever,e xcessive heat inevitably injures normal tissues near tumors,a nd the damage to cancer cells caused by mild hyperthermia is easily repaired by stress-induced heat shock proteins (HSPs). Thus, maximizing the PTT efficiency and minimizing the damage to healthy tissues simultaneously by adopting appropriate therapeutic temperatures is imperative.H erein, an innovative strategy is reported:f erroptosis-boosted mild PTT based on as ingle-atom nanozyme (SAzyme). The Pd SAzyme with atom-economical utilization of catalytic centers exhibits peroxidase (POD) and glutathione oxidase (GSHOx) mimicking activities,a nd photothermal conversion performance,w hich can result in ferroptosis featuring the up-regulation of lipid peroxides (LPO) and reactive oxygen species (ROS). The accumulation of LPO and ROSprovides apowerfulapproach for cleaving HSPs,which enables Pd SAzyme-mediated mildtemperature PTT.

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Near-infrared-II activated inorganic photothermal nanomedicines

Cited by 113 publications

References 118 publications

NIR-II Upconversion Photoluminescence of Er3+ Doped LiYF4 and NaY(Gd)F4 Core-Shell Nanoparticles

NIR-II Upconversion Photoluminescence of Er3+ Doped LiYF4 and NaY(Gd)F4 Core-Shell Nanoparticles

Nanomaterials and their composite scaffolds for photothermal therapy and tissue engineering applications

Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

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