Near-infrared II aggregation-induced electrochemiluminescence of organic dots

Gao, Hang; Lin, Jia-Bao; Wang, Shu-Min; Tao, Qian-Qian; Tang, Ben-Zhong; Chen, Hong-Yuan; Xu, Jing-Juan

doi:10.1039/d3cc05288e

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…t BuO-BP-DMAC ODs were easily prepared via a nanoprecipitation method by mixing t BuO-BP-DMAC and poly(styrene- co -maleicanhydride) (PSMA; Scheme S1). , In brief, a mixture of t BuO-BP-DMAC and PSMA in tetrahydrofuran (THF) solution was prepared, where t BuO-BP-DMAC concentration was 34 μM, and PSMA was 20 wt % of luminophores. Then, under sonication conditions, 2 mL of the above mixture was quickly injected into 10 mL of ultrapure water.…”

Section: Methodsmentioning

confidence: 99%

Enhanced Aggregation-Induced Delayed Electrochemiluminescence Triggered by Spatial Perturbation of Organic Dots

Gao,

Jia,

Lin

et al. 2024

Anal. Chem.

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Development of highly efficient, heavy-metal-free electrochemiluminescence (ECL) materials is attractive but still challenging. Herein, we report an aggregation-induced delayed ECL (AIDECL) active organic dot (OD) composed of a tertbutoxy-group-substituted benzophenone-dimethylacridine compound, which shows high ECL efficiency. The resultant ODs exhibit 2.1-fold higher ECL efficiency compared to control AIDECL-active ODs. Molecular stacking combined with theoretical calculations suggests that tert-butoxy groups effectively participate in the intermolecular interactions, further inhibiting the molecular motions in the aggregated states and thus accelerating radiative decay. On the basis of these ODs exhibiting excellent ECL performance, a proof-of-concept biosensor is constructed for the detection of miR-16 associated with Alzheimer's disease, which demonstrates excellent detection ability with the limit of detection of 1.7 fM. This work provides a new approach to improve the ECL efficiency and enriches the fundamental understanding of the structure−property relationship.

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Section: Methodsmentioning

confidence: 99%