Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury

Abstract

The blood-brain barrier breakdown, as a prominent feature after traumatic brain injury, always triggers a cascade of biochemical events like inflammatory response and free radical-mediated oxidative damage, leading to neurological dysfunction. The dynamic monitoring the status of blood-brain barrier will provide potent guidance for adopting appropriate clinical intervention. Here, we engineer a near-infrared-IIb Ag2Te quantum dot-based Mn single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown of mice after traumatic brain injury. The dynamic change of blood-brain barrier, including the transient cerebral hypoperfusion and cerebrovascular damage, could be resolved with high spatiotemporal resolution (150 ms and ~ 9.6 µm). Notably, the isolated single Mn atoms on the surface of Ag2Te exhibited excellent catalytic activity for scavenging reactive oxygen species to alleviate neuroinflammation in brains. The timely injection of Mn single-atom catalyst guided by imaging significantly promoted the reconstruction of blood-brain barrier and recovery of neurological function after traumatic brain injury.

Building in biologically appropriate multifunctionality in aqueous copper indium selenide-based quantum dots

“…43 In another report, single-atom Mn on the surface of Ag 2 Te QDs was found by Huang et al to exhibit catalytic activity for scavenging reactive oxygen species to alleviate neuroinflammation in the brain. 23 The above research studies indicate that Mn 2+ ions doped into multinary QDs may have undiscovered influences on the nonradiative recombination processes, which deserves further investigation to better reveal the functions of manganese doping.…”

“…7–12 Apart from their good biocompatibility due to the absence of highly toxic elements, their relatively narrow bulk band gaps allow the tuning of photoluminescence from the visible region all the way up to the near-infrared (NIR) spectral region, 13–19 where penetration through biological tissue is favorable. 20–24 In contrast to binary Cd-free QDs, ternary QDs show composition-dependent optical properties while maintaining similar particle sizes, which endows the QDs with analogous pharmacokinetic behaviors in vivo . As a consequence, ternary QDs with NIR emission have been intensively exploited for imaging in vivo .…”

Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

“…Through spatial and temporal assessment of cerebral ischemia, which manifests as regions of diminished blood flow, significant reductions of 76% (from 55 to 13 mm 2 ) in ischemic areas were observed subsequent to Mn/QD SAC treatment. 255 Multiplexed fluorescence imaging enables real-time visualization of multiple biological species within a single biological sample. Zhang et al constructed a dual-channel luminescence imaging system based on NaYF 4 :Yb 0.8 /Tm 0.08 @NaYbF 4 @ NaYF 4 (α-TmNPs) to enable dynamic multiplexed imaging in the wavelength range of 1500−1700 nm (Figure 13a,b).…”

“…Employing imaging techniques for traumatic brain injury enables early detection and assessment of the pathological features, thereby facilitating the implementation of corresponding therapeutic strategies and ultimately aiding in reducing associated mortality rates. ,, To enable timely intervention and treatment of traumatic brain injury, a Mn single-atom catalyst (Mn/QD SAC) based on Ag 2 Te QDs exhibiting emission within the NIR-IIb region (∼1690 nm) was developed for imaging and treatment of blood-brain barrier damage (Figure ). Following Mn doping, there was a remarkable ∼80% increase of fluorescence intensity. Subsequently, the Mn/QD SAC nanocrystals were conjugated with PEG molecules, resulting in the formation of diminutive and distinctly observable vessels with high temporal-spatial resolution (150 ms, ∼9.6 μm) within the NIR-IIb region.…”

Study on the relationship between brain temperature and cytochrome c in hyperacute phase of mouse traumatic brain injury

“…Traumatic brain injury (TBI) is caused by kinetic energy transmitted by external physical forces (blow, acceleration/deceleration and rotation), resulting in skull fractures, hematomas, and deformation and destruction of brain tissue, which is a serious neurosurgical disease with extremely high disability and mortality rates [1,2]. Affected by frequent traffic accidents, earthquakes, and local wars, TBI suffers more than 50 million people worldwide each year, costing the global economy about US$400 billion [3,4].…”