Near‐Infrared Induced miR‐34a Delivery from Nanoparticles in Esophageal Cancer Treatment

Alden, Nick A.; Yeingst, Tyus J.; Pfeiffer, Hanna M.; Celik, Nazmiye; Arrizabalaga, Julien H.; Helton, Angelica M.; Liu, Yiming; Stairs, Douglas B.; Glick, Adam B.; Goyal, Neerav; Hayes, Daniel J.

doi:10.1002/adhm.202303593

Cited by 4 publications

(1 citation statement)

References 70 publications

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“…Research is still ongoing to improve the accessibility of miR-34 family members in translational research and clinical practice in respect to the treatment of breast cancer [41], colon cancer [42], lung cancer [43], oral cancer [44], oesophageal cancer [45] and some others (reviewed in [46]).…”

Section: Functions Of Small Non-coding Rnas and Their Modulation By E...mentioning

confidence: 99%

Impact of Long-Lasting Environmental Factors on Regulation Mediated by the miR-34 Family

Štefánik,

Morová,

Herichová

2024

Biomedicines

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The present review focuses on the interactions of newly emerging environmental factors with miRNA-mediated regulation. In particular, we draw attention to the effects of phthalates, electromagnetic fields (EMFs) and a disrupted light/dark cycle. miRNAs are small non-coding RNA molecules with a tremendous regulatory impact, which is usually executed via gene expression inhibition. To address the capacity of environmental factors to influence miRNA-mediated regulation, the miR-34 family was selected for its well-described oncostatic and neuro-modulatory properties. The expression of miR-34 is in a tissue-dependent manner to some extent under the control of the circadian system. There is experimental evidence implicating that phthalates, EMFs and the circadian system interact with the miR-34 family, in both lines of its physiological functioning. The inhibition of miR-34 expression in response to phthalates, EMFs and light contamination has been described in cancer tissue and cell lines and was associated with a decline in oncostatic miR-34a signalling (decrease in p21 expression) and a promotion of tumorigenesis (increases in Noth1, cyclin D1 and cry1 expressions). The effects of miR-34 on neural functions have also been influenced by phthalates, EMFs and a disrupted light/dark cycle. Environmental factors shifted the effects of miR-34 from beneficial to the promotion of neurodegeneration and decreased cognition. Moreover, the apoptogenic capacity of miR-34 induced via phthalate administration in the testes has been shown to negatively influence germ cell proliferation. To conclude, as the oncostatic and positive neuromodulatory functions of the miR-34 family can be strongly influenced by environmental factors, their interactions should be taken into consideration in translational medicine.

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Section: Functions Of Small Non-coding Rnas and Their Modulation By E...mentioning

confidence: 99%

Impact of Long-Lasting Environmental Factors on Regulation Mediated by the miR-34 Family

Štefánik,

Morová,

Herichová

2024

Biomedicines

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A Multifunctional Aptamer Decorated Lipid Nanoparticles for the Delivery of EpCAM‐targeted CRISPR/Cas9 Plasmid for Efficacious In Vivo Tumor Regression

Sarkar,

Moitra,

Duan

et al. 2024

Adv Healthcare Materials

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Epithelial cell adhesion molecule (EpCAM) gene encodes a type‐I trans‐membrane glycoprotein that is overexpressed in many cancerous epithelial cells and promotes tumor progression by regulating the expression of several oncogenes like c‐myc and other cyclins. Because of this tumorigenic association, the EpCAM gene has been a potential target for anti‐cancer therapy in recent days. Herein, it is attempted to knockout the proto‐oncogenic EpCAM expression by efficiently delivering an all‐in‐one Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) plasmid via a lipid nanoparticle system made out of synthetic stimuli‐sensitive lipids. The plasmid possesses the necessary information in the form of a guide RNA targeted to the EpCAM gene. The aptamer decorated system selectively targets EpCAM overexpressed cells and efficiently inhibits the genetic expression. It has explored the pH‐responsive property of the developed lipid nanoparticles and monitored their efficacy in various cancer cell lines of different origins with elevated EpCAM levels. The phenomenon has further been validated in vivo in non‐immunocompromised mouse tumor models. Overall, the newly developed aptamer decorated lipid nanoparticle system has been proven to be efficacious for the delivery of EpCAM‐targeted CRISPR/Cas9 plasmid.

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Applications of Diels–Alder Chemistry in Biomaterials and Drug Delivery

Yeingst,

Helton,

Hayes

2024

Macromolecular Bioscience

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Recent studies, leveraging click chemistry reactions, have significantly advanced the fields of biomaterials and drug delivery. Of these click reactions, the Diels–Alder cycloaddition is exceptionally valuable for synthetic organic chemistry and biomaterial design, as it occurs under mild reaction conditions and can undergo a retrograde reaction, under physiologically relevant conditions, to yield the initial reactants. In this review, potential applications of the Diels–Alder reaction are explored within the nexus of biomaterials and drug delivery. This includes an emphasis on key platforms such as polymers, nanoparticles, and hydrogels which utilize Diels–Alder for drug delivery, functionalized surfaces, bioconjugation, and other diverse applications. Specifically, this review will focus on the use of Diels–Alder biomaterials in applications of tissue engineering and cancer therapies, while providing a discussion of the advantages, platforms, and applications of Diels–Alder click chemistry.

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Near‐Infrared Induced miR‐34a Delivery from Nanoparticles in Esophageal Cancer Treatment

Cited by 4 publications

References 70 publications

Impact of Long-Lasting Environmental Factors on Regulation Mediated by the miR-34 Family

Impact of Long-Lasting Environmental Factors on Regulation Mediated by the miR-34 Family

A Multifunctional Aptamer Decorated Lipid Nanoparticles for the Delivery of EpCAM‐targeted CRISPR/Cas9 Plasmid for Efficacious In Vivo Tumor Regression

Applications of Diels–Alder Chemistry in Biomaterials and Drug Delivery

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