Near-infrared intraoperative imaging for minimally invasive pulmonary metastasectomy for sarcomas

Predina, Jarrod D.; Newton, Andrew D.; Corbett, Christopher; Shin, Michael; Sulfyok, Lydia Frenzel; Okusanya, Olugbenga T.; Delikatny, Edward J.; Nie, Shuming; Gaughan, Colleen; Jarrar, Doraid; Pechet, Taine T.; Kucharczuk, John C.; Singhal, Sunil

doi:10.1016/j.jtcvs.2018.10.169

Cited by 56 publications

(49 citation statements)

References 17 publications

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“…We think that, this is due to the fact that the patients with primary diagnosis of breast carcinoma were higher in our study compared to other studies in the literature. In many studies in the literature, male patients are the majority [17][18][19]. As another feature of our study, when the primary origin of patients is examined, we see that the most common cases are colorectal carcinoma (34.4%).…”

Section: Discussionsupporting

confidence: 58%

Is video-assisted thoracoscopic surgery sufficient for lymph node dissection in pulmonary metastasectomy?

Kermenli

2020

kitp

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Aim: We evaluated the results of patients undergoing pulmonary metastasectomy with video-assisted thoracoscopic surgery (VATS) and aimed to investigate postoperative lymph node positivity after lymph node dissection (PM-LND). Material and methods: Patients who underwent pulmonary metastasectomy and mediastinal lymph node dissection with VATS between March 2015 and March 2020 in our clinic were included in the study. Results: The mean age of 58 patients who underwent pulmonary metastasectomy and mediastinal lymph node dissection with VATS was 56.5. Thirty-four of the patients were female and 24 were male. A total of 61 surgical procedures, 3 of which were bilateral, were performed in 58 patients. The mean number of resected pulmonary metastases was 1.72. The total number of dissected lymph nodes was 191, with an average of 3.1 per surgical procedure. Colon carcinoma (20 patients) and breast carcinoma (16 patients) were the most common primary tumor origin. Others were thyroid, sarcoma, renal cell carcinoma and melanoma. Unexpected lymph node positivity was present in 9 of 58 patients. Conclusions: Video-assisted thoracoscopic surgery is a technique that can be applied in pulmonary metastasectomy with its advantages such as a low complication rate and rapid recovery. In these patients, lymph node dissection, which is one of the determining factors of prognosis, can be performed effectively with VATS. Mediastinal and hilar lymph node dissection combined with pulmonary metastasectomy is effective in detecting unexpected lymph node positivity.

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Section: Discussionsupporting

confidence: 58%

Is video-assisted thoracoscopic surgery sufficient for lymph node dissection in pulmonary metastasectomy?

Kermenli

2020

kitp

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“…More recently, its use after intradermal and/or subcutaneous injection has been emphasized for lymphatic imaging in the evaluation of lymphedema ( 4 , 5 ) and the detection of sentinel lymph nodes (LNs) ( 6 – 15 ). The ability of ICG to reveal various tumors after IV injection had also been demonstrated in both animals and humans ( 16 – 23 ).…”

Section: Introductionmentioning

confidence: 94%

Near-Infrared Fluorescence Imaging of Breast Cancer and Axillary Lymph Nodes After Intravenous Injection of Free Indocyanine Green

et al. 2021

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BackgroundNear-infrared fluorescence imaging (NIRFI) of breast cancer (BC) after the intravenous (IV) injection of free indocyanine green (fICG) has been reported to be feasible. However, some questions remained unclarified.ObjectiveTo evaluate the distribution of fICG in BC and the axillary lymph nodes (LNs) of women undergoing surgery with complete axillary LN dissection (CALND) and/or selective lymphadenectomy (SLN) of sentinel LNs (NCT no. 01993576 and NCT no. 02027818).MethodsAn intravenous injection of fICG (0.25 mg/kg) was administered to one series of 20 women undergoing treatment with mastectomy, the day before surgery in 5 (group 1) and immediately before surgery in 15 (group 2: tumor localization, 25; and pN+ CALND, 4) as well as to another series of 20 women undergoing treatment with tumorectomy (group 3). A dedicated NIR camera was used for ex vivo fluorescence imaging of the 45 BC lesions and the LNs.ResultsIn group 1, two of the four BC lesions and one large pN+ LN exhibited fluorescence. In contrast, 24 of the 25 tumors in group 2 and all of the tumors in group 3 were fluorescent. The sentinel LNs were all fluorescent, as well as some of the LNs in all CALND specimens. Metastatic cells were found in the fluorescent LNs of the pN+ cases. Fluorescent BC lesions could be identified ex vivo on the surface of the lumpectomy specimen in 14 of 19 cases.ConclusionsWhen fICG is injected intravenously just before surgery, BC can be detected using NIRFI with high sensitivity, with metastatic axillary LNs also showing fluorescence. Such a technical approach seems promising in the management of BC and merits further investigation.

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“…Nanoparticles have been used in various imaging methods such as computed tomography (CT) [ 116 ], magnetic resonance imaging (MRI) [ 117 ], and near-infrared (NIR) imaging [ 118 ] for detection of lung cancers. Chest X-rays and low dose CT-scans provide pictures to show size, shape, and position of cancer cells in lymph nodes [ 15 ].…”

Section: Magnetic Particle Targeting For Diagnosis and Screening Of Lmentioning

confidence: 99%

Magnetic particle targeting for diagnosis and therapy of lung cancers

Saadat

Manshadi

Mohammadi

et al. 2020

Journal of Controlled Release

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Over the past decade, the growing interest in targeted lung cancer therapy has guided researchers toward the cutting edge of controlled drug delivery, particularly magnetic particle targeting. Targeting of tissues by magnetic particles has tackled several limitations of traditional drug delivery methods for both cancer detection (e.g., using magnetic resonance imaging) and therapy. Delivery of magnetic particles offers the key advantage of high efficiency in the local deposition of drugs in the target tissue with the least harmful effect on other healthy tissues. This review first overviews clinical aspects of lung morphology and pathogenesis as well as clinical features of lung cancer. It is followed by reviewing the advances in using magnetic particles for diagnosis and therapy of lung cancers: (i) a combination of magnetic particle targeting with MRI imaging for diagnosis and screening of lung cancers, (ii) magnetic drug targeting (MDT) through either intravenous injection and pulmonary delivery for lung cancer therapy, and (iii) computational simulations that models new and effective approaches for magnetic particle drug delivery to the lung, all supporting improved lung cancer treatment. The review further discusses future opportunities to improve the clinical performance of MDT for diagnosis and treatment of lung cancer and highlights clinical therapy application of the MDT as a new horizon to cure with minimal side effects a wide variety of lung diseases and possibly other acute respiratory syndromes (COVID-19, MERS, and SARS).

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Near-infrared intraoperative imaging for minimally invasive pulmonary metastasectomy for sarcomas

Cited by 56 publications

References 17 publications

Is video-assisted thoracoscopic surgery sufficient for lymph node dissection in pulmonary metastasectomy?

Is video-assisted thoracoscopic surgery sufficient for lymph node dissection in pulmonary metastasectomy?

Near-Infrared Fluorescence Imaging of Breast Cancer and Axillary Lymph Nodes After Intravenous Injection of Free Indocyanine Green

Magnetic particle targeting for diagnosis and therapy of lung cancers

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