Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection

Gao, Ge; Jiang, Yao‐Wen; Jia, Hao‐Ran; Wu, Fu‐Gen

doi:10.1016/j.biomaterials.2018.09.045

Cited by 389 publications

(296 citation statements)

References 85 publications

Supporting

Mentioning

294

Contrasting

Order By: Relevance

“…We further demonstrated that CQ was able to be efficiently released from the nanoparticles upon the stimulation by NIR irradiation and acidic pH (Fig. 1f, g), which is consistent with the previous reports [36,58].…”

Section: Science China Materialssupporting

confidence: 91%

See 1 more Smart Citation

Breaking the vicious cycle between tumor cell proliferation and bone resorption by chloroquine-loaded and bone-targeted polydopamine nanoparticles

et al. 2020

View full text Add to dashboard Cite

The vicious cycle between tumor cell proliferation and bone resorption remarkably elevates the progression and metastasis of bone tumors. Here, we fabricated polyethylene glycol-conjugated alendronate-functionalized and chloroquine (CQ)-loaded polydopamine nanoparticles (PPA/ CQ) for efficient treatment of bone tumors via breaking the vicious cycle. The nanoparticles were efficiently accumulated to the bone tissues, especially the osteolytic lesions around tumors. CQ released from PPA/CQ inhibited osteoclastogenesis via preventing the degradation of tumor necrosis factor (TNF) receptor-associated receptor 3 to attenuate the osteolysis in bone tumors. On the other hand, CQ blocked the autophagy in cancer cells, resulting in improved photothermal killing of cancer cells. Finally, the in vivo experiment revealed that PPA/CQ-associated treatment efficiently inhibited both tumor growth and osteolysis. This work suggests that autophagy inhibition-associated photothermal therapy could be a promising strategy for treating malignant bone tumors.

show abstract

Section: Science China Materialssupporting

confidence: 91%

“…Therefore, CQ was loaded on PPA for autophagy inhibition in this study (Fig. 1a) [58,59]. The obtained PPA/CQ also had a spherical shape, and its average diameter was 114±16 nm (Fig.…”

Section: Resultsmentioning

confidence: 86%

Breaking the vicious cycle between tumor cell proliferation and bone resorption by chloroquine-loaded and bone-targeted polydopamine nanoparticles

et al. 2020

View full text Add to dashboard Cite

show abstract

“…TSG has been developed for drug encapsulation and surgical dressing due to its unique performance. Its phase-transition character can support quantified dosage administration, averts superinfection and wound contact, especially for wound and infection treatment (Gao et al, 2019;Xu et al, 2019). Herein, TSG with the main matrix of poloxamer was Figure 1.…”

Section: Characterization Of Tsg and Cip-ms-g-tsgmentioning

confidence: 98%

PLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus -induced skin infections

et al. 2020

View full text Add to dashboard Cite

When antibiotic-resistant pathogenic bacteria pose a high threat to human health, bacterial multidrug efflux pumps become major contributors to the high-level antibiotic resistance in most microorganisms. Since traditional antibiotics are still indispensable currently, we report a dual drug delivery system to maximize the antibacterial efficacy of antibiotics by inhibiting efflux pumps in bacteria before their exposure to antibiotics. In this research, a microsphere/hydrogel composite was constructed from ciprofloxacin (Cip)-loaded poly (lactic-co-glycolic acid) (PLGA) microspheres and ginsenoside Rh2 (G-Rh2) dispersed thermo-sensitive hydrogel to treat skin infections. In vitro drug release studies indicated that while G-Rh2 in hydrogel presented a faster and short-term release manner to rapidly inhibit the NorA efflux pumps, Cip showed a sustained and long-term release behavior to provide a local high concentration gradient for facilitating drug percutaneous penetration. The combination of Cip and G-Rh2 demonstrated a high degree of synergism against both methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA), hence significantly improving their in vitro antibacterial activity and efficiency. Moreover, the antibacterial performance of the microsphere/hydrogel composite with a sequential release profile is superior to that of other formulations in mouse model of MRSA skin infections, indicating its great potential to treat antibiotic-resistant skin infections.

show abstract

“…Hydrogels with three-dimensional networks have received wide attention due to their successful applications in tissue engineering (Yue et al, 2015;Mohamad et al, 2018;Qu et al, 2018Qu et al, , 2019Edri et al, 2019;Feng et al, 2019), biocatalysis (Diaz et al, 2010), biosensor (Wang et al, 2019), cell culture (Lou et al, 2017;Luo et al, 2019), drug delivery (Gao et al, 2018;Xu et al, 2019), biomedicines (Liow et al, 2017), wound healing (Ahmed et al, 2017), and 3D printing (Censi et al, 2011;Pataky et al, 2012;Malda et al, 2013;Li et al, 2015;Loebel et al, 2017;Lin et al, 2019). In general, hydrogels formed by natural polysaccharides are suitable for 3D printing and encapsulating biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Dual-Enzyme Crosslinking and Post-polymerization for Printing of Polysaccharide-Polymer Hydrogel

Shen

et al. 2020

Front. Chem.

View full text Add to dashboard Cite

Polymer hydrogels are ideal bioprinting scaffolds for cell-loading and tissue engineering due to their extracellular-matrix-like structure. However, polymer hydrogels that are easily printed tend to have poor strength and fragile properties. The gradually polymerized reinforcement after hydrogel printing is a good method to solve the contradiction between conveniently printed and high mechanical strength requirement. Here, a new succinct approach has been developed to fabricate the printable composite hydrogels with tunable strength. We employed the HRP@GOx dual enzyme system to initiate the immediate crosslinking of chondroitin sulfate grafted with tyrosine and the gradual polymerization of monomers to form the composite hydrogels. The detailed two-step gelation mechanism was confirmed by the Fluorescence spectroscopy, Electron paramagnetic resonance spectroscopy and Gel permeation chromatography, respectively. The final composite hydrogel combines the merits of enzymatic crosslinking hydrogels and polymerized hydrogels to achieve adjustable mechanical strength and facile printing performance. The dual-enzyme regulated polymer composite hydrogels are the promising bioscaffolds as organoid, implanted materials, and other biomedical applications.

show abstract

Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection

Cited by 389 publications

References 85 publications

Breaking the vicious cycle between tumor cell proliferation and bone resorption by chloroquine-loaded and bone-targeted polydopamine nanoparticles

Breaking the vicious cycle between tumor cell proliferation and bone resorption by chloroquine-loaded and bone-targeted polydopamine nanoparticles

PLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus -induced skin infections

Dual-Enzyme Crosslinking and Post-polymerization for Printing of Polysaccharide-Polymer Hydrogel

Contact Info

Product

Resources

About