2013
DOI: 10.1002/anie.201308834
|View full text |Cite
|
Sign up to set email alerts
|

Near‐Infrared Light‐Mediated Photoactivation of a Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging by Upconversion‐Luminescent Nanoparticles

Abstract: Platinum-based drugs are among the most active antitumor reagents in clinical practice; their application is limited by side effects and drug resistance. A novel and personalized near-infrared (NIR) light-activated nanoplatform is obtained by combining a photoactivatable platinum(IV) prodrug and a caspase imaging peptide conjugated with silica-coated upconversion-luminescent nanoparticles (UCNPs) for the remote control of antitumor platinum prodrug activation, and simultaneously for real-time imaging of apopto… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
177
0
1

Year Published

2014
2014
2019
2019

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 289 publications
(180 citation statements)
references
References 61 publications
1
177
0
1
Order By: Relevance
“…47 Coincidentally, a similar NIR light-activated nanocomposite composed of a Pt IV prodrug, a peptide probe, and UCNPs was designed later for the remote control of prodrug activation and real-time imaging of apoptosis. 48 …”
Section: Accounts Of Chemical Researchmentioning
confidence: 97%
“…47 Coincidentally, a similar NIR light-activated nanocomposite composed of a Pt IV prodrug, a peptide probe, and UCNPs was designed later for the remote control of prodrug activation and real-time imaging of apoptosis. 48 …”
Section: Accounts Of Chemical Researchmentioning
confidence: 97%
“…), and UV-visible light [185,186]. Recently, Lin et al [162] and Xing et al [163] reported NIR light-triggered reduction of Pt(IV) prodrugs by taking advantage of UCNPs.…”
Section: Nir Light-triggered Photoreductionmentioning
confidence: 97%
“…Pt(IV) prodrugs [163] Considering that the released DOX exhibited much stronger fluorescence compared with DOX loaded onto UCNPs, the fluorescence of which was quenched owing to the aggregation of DOX molecules, the fluorescence of DOX could be used to Yb@NaLuF 4 UCNPs without Tm 3+ activator) and saline. In all mice groups, the tumors were exposed to 980-nm laser.…”
Section: Pt(iv) Prodrugsmentioning
confidence: 98%
“…In PDT, visible or nearinfrared light is used to photo-activate inert prodrugs to cytotoxic agents. Examples include the photo-activation of chlorin e6 (46) to generate highly reactive singlet oxygen species, and platinum(IV)-based prodrugs to active platinum(II) species (47). PDT shares some similarities with radiosensitizing prodrugs, and the loco-regional irradiation per se may be considered as targeted therapy.…”
Section: Active Conversion Of Cancer-targeted Prodrugsmentioning
confidence: 99%