Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe&lt;sub&gt;3&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt; carbon dots with graphitic black phosphorus quantum dots

Zhang, Ming; Wang, Wentao; Cui, Yaya; Zhou, Ninglin; Shen, Jian

doi:10.2147/ijn.s156434

Cited by 56 publications

(32 citation statements)

References 40 publications

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“…A sustained release dosage form with a suitable formulation can delay or control the rate of release of the drug in the body and maintain an effective concentration of the drug in the body to prolong drug action. 31 Compared with the conventional preparation, the sustained release preparation can prolong drug release, improving patient compliance and reducing the frequency of administration. 32,33 The purpose of this study was to establish a high bioavailability and sustained release delivery system for nintedanib based on electrospray technology.…”

Section: Introductionmentioning

confidence: 99%

A high bioavailability and sustained-release nano-delivery system for nintedanib based on electrospray technology

Liu¹,

Du²,

Li³

et al. 2018

IJN

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BackgroundNintedanib is a new tyrosine kinase inhibitor and growth factor antagonist. It can be used to treat idiopathic pulmonary fibrosis diseases. Nintedanib has poor solubility in the intestinal tract environment, which leads to low bioavailability of just 4.7%.MethodsIn this study, a nintedanib solid dispersion was prepared by electrospray technology with an optimized formula (nintedanib:PVPK30:Soybean lecithin=1:5:0.25) and electrospray parameters (21 kV voltage, 18 cm receiving distance, 0.3 mL/h solution flow rate, 0.5 mm pinhole inner diameter).ResultsThe accumulative release rate of the optimized solid dispersion was more than 60% in 30 minutes and 100% in 60 minutes. The size distribution was uniform and the surface observed with scanning electron microscopy (SEM) was smooth. The DSC and X-ray diffraction results showed that nintedanib existed in the solid dispersion through an amorphous form. Nintedanib solid dispersion sustained-release capsules were prepared to prolong drug release, improve patient compliance and reduce side effects. The accumulative release rate from the sustained release capsules was 35.17%, 54.78%, 70.58%, and 93.93% after 2 h, 6 h, 8 h, and 12 h, respectively, having obvious sustained release effects in vitro. The release behavior of solid dispersion sustained-release capsules in vitro was in accordance with the Ritger-Peppas model. The in vivo studies of nintedanib soft capsules, solid dispersion and nintedanib sustained release capsules in SD rats were investigated; the results showed that the Tmax of the soft capsule, solid dispersion and sustained release capsules were 3 h, 2 h, and 6 h, respectively. The Cmax were 2.945 mg/mL, 5.32 mg/mL, and 3.75 mg/mL, respectively, while the AUC0–24 h was 15.124 mg·h/mL, 23.438 mg·h/mL, and 24.584 mg·h/mL, respectively. The relevant bioavailability of the sustained-release capsules was 162.55% compared to the nintedanib soft capsule and 104.89% compared to the nintedanib solid dispersion.ConclusionThe results suggested superior bioavailability and a sustained-release effect from nintedanib sustained-release capsules, as compared to the reference (commercial nintedanib soft capsule).

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Section: Introductionmentioning

confidence: 99%

A high bioavailability and sustained-release nano-delivery system for nintedanib based on electrospray technology

Liu¹,

Du²,

Li³

et al. 2018

IJN

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“…In 2016, Zheng’s group reported iRGD-modified ICG liposomes for PTT/PDT against breast tumors with a TGI up to ~ 98% [ 50 ]. In 2018, Shen’s group reported the assembly of iron oxide carbon dot NPs conjugated with black phosphorus quantum dots and realized a TGI of 98.8% [ 51 ]. Compared with these functional antitumor nanomaterials, the FPPI NPs developed in the present work demonstrated comparable tumor inhibition performance (TGI = 93%), implying a promising potential for cancer therapeutics.…”

Section: Resultsmentioning

confidence: 99%

Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy

et al. 2018

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Indocyanine green (ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation, which causes insufficient bioavailability at the tumor site. Herein, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe3O4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe3O4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy.Electronic supplementary materialThe online version of this article (10.1007/s40820-018-0227-z) contains supplementary material, which is available to authorized users.

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“…Zhang et al 159 developed genipin (GP)-polyglutamic acid (PGA)-Fe 3 O 4 -CDs@BPQDs nanocomposites to treat cancer. Photothermal activity of these composites inside the irradiated tumors were monitored by a thermal camera (Figs.…”

Section: Synergistic Therapymentioning

confidence: 99%

Black phosphorus as a versatile nanoplatform: From unique properties to biomedical applications

Xiong

Chen

Liu

et al. 2020

J. Innov. Opt. Health Sci.

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Black phosphorus (BP) or phosphorene, a new superstar among two-dimensional (2D) materials, has sparked huge scientific interest since its discovery in 2014. BP offers unique characteristics including high drug loading efficiency, excellent photodynamic and photothermal properties and good biocompatibility. These characteristics expand versatility of BP in nanomedicine. Although the outlook of BP seems promising, its practical biomedical applications are still at the very initial stage especially in comparison to other thoroughly investigated inorganic nanomaterials. This paper reviews BP structure and properties as well as its preparation approaches with the emphasis on techniques to improve BP stability and biocompatibility for their further usage in physiological environment. Meanwhile, recent progress made in various biomedical research fields from bioimaging to biosensing is discussed. Last, but not least, current challenges and prospects for BP in biomedicine are briefly examined, which will be useful to guide future developments of BP.

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Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe<sub>3</sub>O<sub>4</sub> carbon dots with graphitic black phosphorus quantum dots

Cited by 56 publications

References 40 publications

A high bioavailability and sustained-release nano-delivery system for nintedanib based on electrospray technology

A high bioavailability and sustained-release nano-delivery system for nintedanib based on electrospray technology

Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy

Black phosphorus as a versatile nanoplatform: From unique properties to biomedical applications

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