Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment

Yang, Guangbao; Liu, Jingjing; Wu, Yifan; Feng, Liangzhu; Liu, Zhuang

doi:10.1016/j.ccr.2016.04.004

Cited by 176 publications

(117 citation statements)

References 221 publications

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“…First, by incubating 4T1 cells with both types of micelles (aza‐BDTP = 5 µg mL −1 ) for 4 h, we observed strong aza‐BDTP fluorescence inside those cells colocalized with the fluorescence of lyso‐tracker, indicating that those micelles were engulfed by cells via the endocytosis pathway (Figure S9, Supporting Information). Then, it was uncovered that those 4T1 cells incubated with both types of micelles (aza‐BDTP = 5 µg mL −1 ) upon exposure to a 785 nm laser irradiation (0.25 W cm −2 , 20 min) showed remarkably enhanced intracellular aza‐BDTP fluorescence compared to those without laser exposure (Figure c), indicating that the mild photothermal effect of aza‐BDTP and aza‐BDTP/PTX micelles could be utilized to increase their cell internalization, consistent to our previous findings …”

Section: Resultssupporting

confidence: 88%

Surfactant‐Stripped Micelles of Near Infrared Dye and Paclitaxel for Photoacoustic Imaging Guided Photothermal‐Chemotherapy

Zhang

Feng

Wang

et al. 2018

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Development of nanoagents with strong near‐infrared (NIR) absorbance and high photothermal conversion capacity is highly desired for efficient photoacoustic (PA) imaging and photothermal therapy of cancers. Herein, surfactant‐stripped micelles with photostable near‐infrared dye, β‐thiophene‐fused BF2‐azadipyrromethene (aza‐BDTP), are prepared in the presence of paclitaxel (PTX) with Pluronic F127 as the surfactant. Distinct from hydrophobic aza‐BDTP and PTX, the obtained surfactant‐stripped micelles aza‐BDTP/PTX show excellent solubility, physiological stability, and high loading efficiencies for corresponding aza‐BDTP and PTX. Intriguingly, these aza‐BDTP/PTX micelles exhibit high photothermal conversion efficiency at 33.9%, significantly higher than 16.9% for bare aza‐BDTP molecules, owing to aggregation‐induced quenching of aza‐BDTP fluorescence. With excellent photostability, aza‐BDTP/PTX micelles appear to be a highly stable photoacoustic imaging probe and show efficient tumor accumulation as visualized under photoacoustic imaging upon intravenous injection. After being irradiated with a 785 nm laser, 4T1 tumors on the mice with systemic administration of aza‐BDTP/PTX micelles are fully eradiated without any recurrences within 60 d. This work presents a general method for efficient encapsulation of hydrophobic aza‐BDTP and PTX, obtaining hybrid aza‐BDTP/PTX micelles as promising nanotheranostics for imaging guided cancer combination therapy.

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Section: Resultssupporting

confidence: 88%

Surfactant‐Stripped Micelles of Near Infrared Dye and Paclitaxel for Photoacoustic Imaging Guided Photothermal‐Chemotherapy

Zhang

Feng

Wang

et al. 2018

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“…In recent years, near‐infrared (NIR) light‐responsive nanomaterials have gained considerable interest owning to their excellent tissue‐penetration capacity . These light‐responsive nanomaterials can be stimulated by NIR light and convert it into cytotoxic heat for ablating tumors without damaging surrounding normal tissues .…”

Section: Nanoformulations For Betulinic Acid Deliverymentioning

confidence: 99%

Therapeutic applications of betulinic acid nanoformulations

Saneja

Arora

Kumar

et al. 2018

Annals of the New York Academy of Sciences

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Betulinic acid (BA), a naturally occurring plant-derived pentacyclic triterpenoid, has gained attention in recent years owing to its broad-spectrum biological and medicinal properties. Despite the pharmacological activity of BA, it has been associated with some drawbacks, such as poor aqueous solubility and short half-life in vivo, which limit therapeutic application. To solve these problems, much work in recent years has focused on enhancing BA's aqueous solubility, half-life, and efficacy by using nanoscale drug delivery systems. Several different kinds of nanoscale delivery systems-including polymeric nanoparticles, magnetic nanoparticles, liposomes, polymeric conjugates, nanoemulsions, cyclodextrin complexes, and carbon nanotubes-have been developed for the delivery of BA. Here, we focus on the recent developments of novel nanoformulations used to deliver BA in order to improve its efficacy.

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“…The photochemical stimulus provides precise spatial and temporal control over the switching process, which is of particular value for the smart delivery of drugs . That is to say, one can reduce undesired side effects, improve selectivity and therefore optimize drug's potency by exposing affected areas to the stimulus and concurrently tune the pharmacokinetics via modulation of the exposure time/intensity . So far, isomerization of azobenzenes, dithienylethene and spyropirans as well as degradation of o ‐nitrobenzyl derivatives constitutes prevalent photochemical strategies for manipulating chemical/physical characteristics of soft matter with light .…”

Section: Introductionmentioning

confidence: 96%

Light‐Triggered Transformation of Molecular Baskets into Organic Nanoparticles

Border

Pavlović

Liu

et al. 2018

Chemistry A European J

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Discovering novel and functional photoresponsive materials is of interest for improving controlled release of molecules and scavenging toxic compounds for cleaning our environment or designing chemosensors. In this study, we report on the photoinduced decarboxylation of basket 1 , containing three glutamic acids at its rim. This concave compound is, in an aqueous environment (30 mm phosphate buffer at pH 7.0), monomeric ( H NMR DOSY, DLS) with glutamic acid residues randomly oriented about its rim ( H NMR and MM-OPLS3). The irradiation (300 nm) of 1 leads to the exclusive removal of its α-carboxylates to give amphiphilic 2 possessing γ-carboxylates. The photochemical transformation is a consecutive reaction with mono- and bis-decarboxylated products observed with H NMR spectroscopy and ESI mass spectrometry. Amphiphilic 2 is a preorganized molecule (MM-OPLS3) that, in water, aggregates into organic nanoparticles (ca. 50-200 nm in diameter; DLS, TEM and cryo-TEM) having a critical aggregation concentration of 12 μm (UV/Vis). As the transition of monomeric 1 into nanoparticulate 2 is triggered with light, we reasoned that stimuli-responsive formation of the soft material lends itself to nanotechnology applications such as controlled release or scavenging of targeted compounds.

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Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment

Cited by 176 publications

References 221 publications

Surfactant‐Stripped Micelles of Near Infrared Dye and Paclitaxel for Photoacoustic Imaging Guided Photothermal‐Chemotherapy

Surfactant‐Stripped Micelles of Near Infrared Dye and Paclitaxel for Photoacoustic Imaging Guided Photothermal‐Chemotherapy

Therapeutic applications of betulinic acid nanoformulations

Light‐Triggered Transformation of Molecular Baskets into Organic Nanoparticles

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