Near‐Infrared‐Light‐Triggered Antimicrobial Indium Phosphide Quantum Dots

Levy, Max; Bertram, John R.; Eller, Kristen A.; Chatterjee, Anushree; Nagpal, Prashant

doi:10.1002/anie.201906501

Cited by 23 publications

(39 citation statements)

References 26 publications

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“…The in vitro cytotoxicity of CWS NCs was tested by using lactate dehydrogenase (LDH) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assays. HeLa cells are commonly used as the model cell lines for toxicity assessment in vitro , and they were also adopted in this study. , After incubation with CWS NCs for 24 h, the viability of HeLa cells was approximately 100%, even at the concentration of CWS NCs up to 64 μg mL –1 (Figure a). SEM and elemental mapping images (Figure S19) show that few CWS NCs attach to the surface of HeLa cells, though HeLa cells were exposed to 100 μg mL –1 of CWS NCs.…”

Section: Resultsmentioning

confidence: 99%

Efficient Bacteria Killing by Cu₂WS₄ Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability

et al. 2019

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Antibacterial agents with high antibacterial efficiency and bacteria-binding capability are highly desirable. Herein, we describe the successful preparation of Cu2WS4 nanocrystals (CWS NCs) with excellent antibacterial activity. CWS NCs with small size (∼20 nm) achieve more than 5 log (>99.999%) inactivation efficiency of both Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) at low concentration (<2 μg mL–1) with or without ambient light, which is much better than most of the reported antibacterial nanomaterials (including Ag, TiO2, etc.) and even better than the widely used antibiotics (vancomycin and daptomycin). Antibacterial mechanism study showed that CWS NCs have both enzyme-like (oxidase and peroxidase) properties and selective bacteria-binding ability, which greatly facilitate the production of reactive oxygen species to kill bacteria. Animal experiments further indicated that CWS NCs can effectively treat wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). This work demonstrates that CWS NCs have the potential as effective antibacterial nanozymes for the treatment of bacterial infection.

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Section: Resultsmentioning

confidence: 99%

Efficient Bacteria Killing by Cu₂WS₄ Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability

et al. 2019

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“…50 These can be remedied by probing the toxicity and efficacy of other QDs with similar electronic properties but made up of relatively benign materials, such as indium phosphide (InP) QDs. 22 Recently these QDs were shown to be activated by near-infrared (NIR) light, 51 a wavelength range that falls within the optical transparency window for skin and tissue, 22 to specifically generate superoxide. These QDs have shown great promise in vitro as alternatives to CdTe QDs.…”

Section: ■ Discussionmentioning

confidence: 99%

“…These QDs have shown great promise in vitro as alternatives to CdTe QDs. 51 The exploration of QDs comprised of safer materials can be combined with a variety of other pursuits to prepare this therapy for clinical use. As the efficacy of the treatment depends strongly on light intensity, the concentration of bacteria at the infection site, the identity of the target bacteria, and the QD concentration at the infection site, improvements to the treatment can be made in each of these areas.…”

Section: ■ Discussionmentioning

confidence: 99%

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Photoexcited Quantum Dots as Efficacious and Nontoxic Antibiotics in an Animal Model

McCollum

Levy

Bertram

et al. 2021

ACS Biomater. Sci. Eng.

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Drug-resistant bacterial infections are a growing cause of illness and death globally. Current methods of treatment are not only proving less effective but also perpetuate evolution of new resistance. Here we propose, through an in vivo model, a new treatment for drug-resistant bacterial infection that uses semiconductor nanoparticles, called quantum dots (QDs), that can be activated by light to produce superoxide to specifically and effectively kill drug-resistant bacteria. We adapt this technology for in vivo assessment of toxicity and treatment of a subcutaneous infection in mice. As our cadmium telluride QDs with 2.4 eV band gap (CdTe-2.4 QDs) are activated by blue light, we engineered LED patches to adhere to the infection site on mice, thus providing the light necessary for the activity of injected QDs and treatment of the infection. We show, through assessment of body weight, histology, and inflammation and oxidative stress markers in serum, that the CdTe-2.4 QDs are nontoxic at concentrations that reduce drug-resistant bacterial viability in subcutaneous abscesses. Further, CdTe-2.4 QDs did not accumulate in the body and were safely excreted in urine via renal clearance. CdTe-2.4 QD treatment decreased abscess viability by as much as 7 orders of magnitude. We thus propose an alternative treatment approach for drug-resistant topical infections: the injection of a low concentration of QDs and the application of an adhesive patch comprising only an LED and a battery. This treatment could revolutionize last-resort treatments of burn wounds, cellulitis, and other skin infections.

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“…The proposed therapeutic QD nanoparticles which could generate superoxide radicals intracellularly were proven to be suitable for NIR-mediated treatment with superb diffusion in microbes and excellent biological compatibility through renal clearance. 57…”

Section: Photodynamic Therapymentioning

confidence: 99%

Near-Infrared Light Brightens Bacterial Disinfection: Recent Progress and Perspectives

Han

Lau

Cong

et al. 2020

ACS Appl. Bio Mater.

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Bacterial infection is a universal threat to public health, which not only causes many serious diseases but also exacerbates the condition of the patients of cancer, pandemic diseases, e.g., COVID-19, and so on. Antibiotic therapy has been used to be an effective way for common bacterial disinfection. However, due to the misuse and abuse of antibiotics, more and more antibiotic-resistant bacteria have emerged as fatal threats to human beings. At present, more than 700,000 patients die every year with bacterial infections because of the lack of effective treatment. It is frustrating that the pace of development of antibiotics lags far behind that of bacterial resistance, with an estimation of 10 million deaths per year from bacterial infections after 2050. Facing such a rigorous challenge, approaches for bacterial disinfection are urgently demanded. The recently developed near-infrared (NIR) light-irradiation-based bacterial disinfection is highly promising to shatter bacterial resistance by employing NIR lightresponsive materials as mediums to generate antibacterial factors such as heat, reactive oxygen species (ROS), and so on. This treatment approach is proved to be a potent candidate to accurately realize spatiotemporal control, while effectively eradicating multidrug-resistant bacteria and inhibiting antibiotic resistance. Herein, we summarize the latest progress of NIR light-based bacterial disinfection. Ultimately, current challenges and perspectives in this field are discussed.

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Near‐Infrared‐Light‐Triggered Antimicrobial Indium Phosphide Quantum Dots

Cited by 23 publications

References 26 publications

Efficient Bacteria Killing by Cu₂WS₄ Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability

Efficient Bacteria Killing by Cu₂WS₄ Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability

Photoexcited Quantum Dots as Efficacious and Nontoxic Antibiotics in an Animal Model

Near-Infrared Light Brightens Bacterial Disinfection: Recent Progress and Perspectives

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Near‐Infrared‐Light‐Triggered Antimicrobial Indium Phosphide Quantum Dots

Cited by 23 publications

References 26 publications

Efficient Bacteria Killing by Cu2WS4 Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability

Efficient Bacteria Killing by Cu2WS4 Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability

Photoexcited Quantum Dots as Efficacious and Nontoxic Antibiotics in an Animal Model

Near-Infrared Light Brightens Bacterial Disinfection: Recent Progress and Perspectives

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Product

Resources

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Efficient Bacteria Killing by Cu₂WS₄ Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability

Efficient Bacteria Killing by Cu₂WS₄ Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability