Near‐infrared light-triggered nitric oxide nanocomposites for photodynamic/photothermal complementary therapy against periodontal biofilm in an animal model

Xiao-yue, WU; Qi, Manlin; Liu, Chengyu; Yang, Qian; Li, Sijia; Shi, Fangyu; Sun, Xiaofeng; Wang, Lin; Li, Chunyan; Dong, Biao

doi:10.7150/thno.83745

Cited by 15 publications

(5 citation statements)

References 59 publications

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“…Currently, the commonly used NO donors mainly included organic nitrates, diazodiol, and S -nitroso thiols . However, these NO donors were instable and their byproducts had toxicity, which resulted in difficulty in applications. , l -Arginine ( l -Arg) was a natural amino acid, which generally existed in meat and dairy products. It possesses unique guanidine structure in the R group, which made it become a recognized NO donor with reassuring biosafety .…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species Responsive Nitric Oxide Release for Enhanced Photodynamic Antibacterial Therapy of Scaffolds

Qi,

Liu,

et al. 2024

ACS Appl. Polym. Mater.

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Photodynamic therapy (PDT) presented tremendous potential for combating implant-related infections, but its antibacterial efficacy was constrained by rapid electron−hole pair recombination of photosensitizers and barrier action of a dense biofilm on reactive oxygen species (ROS). Herein, a cascade phototherapeutic AuKN-LA nanosystem was constructed by depositing Au nanoparticles and L-arginine (LA) on potassium niobate (KN) photosensitizer. In the nanosystem, Au nanoparticles with lower Fermi levels could capture photogenerated electrons and thus suppress electron−hole pair recombination to enhance ROS generation. Especifically, L-arginine could cascade trigger by the generated ROS to release nitric oxide (NO) to destroy the biofilm, thereby facilitating the entry of ROS. Furthermore, NO itself possessed antibacterial activity, which could form synergy with PDT. Then, the nanosystem was introduced into poly(L-lactic acid) scaffolds fabricated by laser additive manufacturing. Photoelectrochemical and ROS analysis proved that the electron−hole pair separation was improved, significantly increasing ROS generation. NO detection and crystal violet staining showed that the scaffolds could effectively remove the biofilm by sustainably releasing NO under light irradiation. As a consequence, the scaffolds exhibited excellent antibacterial rates of 98.7% and 99.2% against E. coli and S. aureus, respectively, by disrupting bacterial cell membranes and causing leakage of nucleic acid molecules and proteins.

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Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species Responsive Nitric Oxide Release for Enhanced Photodynamic Antibacterial Therapy of Scaffolds

Qi,

Liu,

et al. 2024

ACS Appl. Polym. Mater.

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show abstract

Section: Introductionmentioning

confidence: 99%

“…21 In serving as an adjunct therapy to enhance mainstream treatments such as PDT, NO reacts with the ROS generated during PDT to produce highly lethal peroxynitrite (ONOO − ) species that are more effective against bacteria than NO alone. 22,23 Despite the numerous advantages of NO in antimicrobial therapy applications, its volatility, explosive release, and short half-life are significant challenges that necessitate the development of nanomaterials capable of stable storage and of stimulating the on-demand release of NO. 24 To address these issues, we constructed cationic SNP/PEI-ICG@PEG nanoparticles that could target bacteria with excellent biosafety and photostability and could thus can be utilized as treatment platform for multiple antibacterial modes, including mild PTT, PDT and controlled NO release under 808 nm laser irradiation (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Light-Triggered NO Nanogenerator for Gas-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy to Eliminate Biofilms

Li,

Tian,

Qin

et al. 2024

IJN

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“…Photodynamic therapy (PDT) has recently gained recognition as an effective, noninvasive antimicrobial treatment [9]. Using photosensitizers, PDT generates reactive oxygen species (ROS) when exposed to light [10], offering advantages such as resistance to drug resistance, painlessness, quick treatment, and minimal tissue damage [11][12][13]. Chlorin e6 (Ce6), derived from natural chlorophyll and an FDA-approved photosensitizer, has advantages such as efficient ROS generation, brief photosensitization, and strong red-light absorption [14].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms

Shi,

Zheng,

Jin

et al. 2024

Preprint

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The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the constraints of insufficient biofilm infiltration and the absence of precision in pathogen-specific targeting. In this current study, we have used chlorin e6 (Ce6), zeolitic imidazolate framework-8 (ZIF-8), polydopamine (PDA), and UBI peptide to formulate an innovative nanosystem meticulously engineered to confront bacterial infections and effectually dismantle biofilm architectures through the concerted mechanism of photodynamic therapy (PDT)/photothermal therapy (PTT) therapies, including in-depth research, especially for oral bacteria and oral biofilm. Ce6@ZIF-8-PDA/UBI nanosystem, with effective adhesion and bacteria-targeting, affords a nuanced bacterial targeting strategy and augments penetration depth into oral biofilm matrices. The Ce6@ZIF-8-PDA/UBI nanosystem potentiated bacterial binding and aggregation. Upon exposure to near-infrared (NIR) irradiation, Ce6@ZIF-8-PDA/UBI showed excellent antibacterial effect on S. aureus, E. coli, F. nucleatum, and P. gingivalis and exceptional light-driven antibiofilm activity to P. gingivalis biofilm, which was a result of the efficient bacterial localization mediated by PDA/UBI, as well as the PDT/PTT facilitated by Ce6/PDA interactions. Collectively, these versatile nanoplatforms augur a promising and strategic avenue for controlling infection and biofilm, thereby holding significant potential for future integration into clinical paradigms. The original application of the developed nanosystem in oral biofilms also provides a new strategy for effective oral infection treatment.

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Near‐infrared light-triggered nitric oxide nanocomposites for photodynamic/photothermal complementary therapy against periodontal biofilm in an animal model

Cited by 15 publications

References 59 publications

Reactive Oxygen Species Responsive Nitric Oxide Release for Enhanced Photodynamic Antibacterial Therapy of Scaffolds

Reactive Oxygen Species Responsive Nitric Oxide Release for Enhanced Photodynamic Antibacterial Therapy of Scaffolds

Near-Infrared Light-Triggered NO Nanogenerator for Gas-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy to Eliminate Biofilms

Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms

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