Near-Infrared (NIR)-Absorbing Conjugated Polymer Dots as Highly Effective Photothermal Materials for <i>In Vivo</i> Cancer Therapy

Li, Shengliang; Wang, Xiaoyu; Hu, Rong; Chen, Hui; Li, Meng; Wang, Jianwu; Wang, Yunxia; Liu, Libing; Lv, Fengting; Liang, Xing‐Jie

doi:10.1021/acs.chemmater.6b03738

Cited by 201 publications

(154 citation statements)

References 42 publications

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“…[4] In addition, many groups have prepared the dimensionalc ontrollable self-assembly systemsb ased on organics emiconductors that displayed high sensitivity and selectivity for biomolecules via fluorescencec ell imaging technology. [5] These observations encouraged us to design and synthesize novel organic semiconductors.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Optoelectronic and Self‐Assembly Properties of Diazadioxaacene Derivatives

Pan

Duan

Zhai

et al. 2017

Chemistry An Asian Journal

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Two novel diazadioxaacene derivatives (ADOP and ADOQ) have been successfully synthesized and characterized. Their single crystal analyses disclose that molecule ADOP forms a twisted topology configuration, whereas ADOQ adopts reclining-chair architecture. Both of them emit strong blue fluorescence in organic solvents. Moreover, they can self-assemble to form regular nanobelts and nanowires, respectively, via a simple surfactant-assisted method.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Optoelectronic and Self‐Assembly Properties of Diazadioxaacene Derivatives

Pan

Duan

Zhai

et al. 2017

Chemistry An Asian Journal

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“…[5][6][7][8] Such versatile and extraordinary properties have motivated researchers to explore the multifunctional Pdots for biological applications. Significant efforts have recently been focusedo ns ynthesizing new conjugated polymers, [9,10] developing functionalization strategies, [11,12] and designing signal transduction/amplification schemes. [13,14] The usefulness of Pdots in biological applications is strongly dependento nt he quality of the surfacef unctionalization to enables pecific recognition.…”

mentioning

confidence: 99%

Light‐Induced PEGylation and Functionalization of Semiconductor Polymer Dots

et al. 2017

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As emiconductor polymer with side-chain oxetane groups was synthesized to form highly fluorescent, functionalized, andu ltra-stablep olymer dots (Pdots). A facile light-induced strategy covalently links functional polyethylene glycol (PEG) molecules to polymer dots while simultaneously providing functional groups for bioconjugation. The influence of photo-crosslinkable sidechains and PEG molecules on the properties and performance of Pdots was systematically investigated. The Pdots functionalized by photo-crosslinking show specific labeling and negligible non-specific binding as compared to non-functionalized Pdots. The resultsp rovide av iable strategy for nanoparticle assembly and functionalization.Semiconducting polymers have attracted considerable interest in both optoelectronic and biomedical applications over past decades. While they were originally developed for optoelectronic devices,t he adaptation of semiconducting polymers into nanoparticles has yielded ar apidlyi ncreasing number of applicationso ft he polymer dots (Pdots)i nb iomedical theranostics.[1-4] The attractiveness of Pdots foro pticali maging, sensing, and phototherapy is due to their superior characteristics, such as large absorption coefficients, excellent photostability,b iocompatibility,a nd suitability for the efficient generation of either photoluminescence, photoacoustic waves, or reactive oxygen species (ROS).[5-8] Such versatile and extraordinary properties have motivated researchers to explore the multifunctional Pdots for biological applications. Significant efforts have recently been focusedo ns ynthesizing new conjugated polymers, [9,10] developing functionalization strategies, [11,12] and designing signal transduction/amplification schemes. [13,14] The usefulness of Pdots in biological applications is strongly dependento nt he quality of the surfacef unctionalization to enables pecific recognition. Hence, many strategies have been implemented to modifyP dot surfaces with different functional molecules, for example, PEGylated lipids and amphiphilic polymers. [15,16] These functional molecules consist of hydrophobic components and hydrophilic segmentsw ith functional groups (e.g.,p olyethylene glycol,a mines, and carboxylic acids). During the Pdot formation, the hydrophobic segments are physically associated with polymer nanoparticles, while the hydrophilic chains extend partlyi nto the aqueous environment for further bioconjugation. Chiu's group developed ad irect functionalization strategy by modifying the side chain of the conjugated polymer.[17] Pdots formed from such functional polymers would directly have surface reactive groups for bioconjugation. In this strategy,the density of the side-chain functional groupss hould be well controlled to preventt he formationo farelatively loose structure, which can significantly affect nanoparticle stability and fluorescenceb rightness. However, challenges remain in the functionalization of Pdot surfaces for biomedical applications. Ideal semiconducting polymer nanoparticles ...

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“…Conjugated polymer‐based supramolecular networks have attracted extensive interest in the development of smart systems with stimuli responsiveness that takes advantage of their sensitivity to external signals such as pH, temperature, CO 2 , and light . For example, Wang and colleagues reported the near‐infrared (NIR)‐activated photothermal effect of an assembly formed by a diketopyrrolopyrrole (DPP)‐containing conjugated polymer . Our group also constructed a CO 2 ‐responsive supramolecular assembly catalyzed by carbonic anhydrase and based on conjugated polythiophene for the monitoring and sequestering of CO 2 .…”

Section: Introductionmentioning

confidence: 99%

“…[15] For example, Wang and colleagues reported the near-infrared (NIR)-activatedp hotothermal effect of an assemblyf ormed by ad iketopyrrolopyrrole (DPP)-containing conjugated polymer. [16] Our group also constructed aC O 2 -responsives upramolecular assembly catalyzed by carbonic anhydrase and based on conjugated polythiophene for the monitoring and sequestering of CO 2 . [17] In the present work, we fabricated as upramolecular assembly with as tress-stiffening mechanical property by adopting as trategy of integrating conjugated polymers with PIC networks through noncovalent interactions.…”

Section: Introductionmentioning

confidence: 99%

A Multiple‐Stimulus‐Responsive Biomimetic Assembly Based on a Polyisocyanopeptide and Conjugated Polymer

Meng

Xing

Yuan

et al. 2017

Chemistry An Asian Journal

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An assembly was fabricated and was revealed to be a multiple-stimulus-responsive biomimetic hybrid polymer architecture. It was constructed by the hydrophobic interactions between a conjugated polyfluorene that contained 2,1,3-benzothiadiazole units (PFBT) and a tri(ethylene glycol)-functionalized polyisocyanopeptide (3OEG-PIC). The introduction of PFBT to the polyisocyanopeptide (PIC) network allowed for the incorporation of responsiveness to multiple stimuli including temperature, CO , carbonic anhydrase, and nonlinear mechanics, which mimics natural processes and interactions. Furthermore, the light-harvesting and signal amplification characteristics of PFBT endowed the supramolecular assembly with the essential function of fluorescence monitoring for biological processes.

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Near-Infrared (NIR)-Absorbing Conjugated Polymer Dots as Highly Effective Photothermal Materials for In Vivo Cancer Therapy

Cited by 201 publications

References 42 publications

Synthesis, Optoelectronic and Self‐Assembly Properties of Diazadioxaacene Derivatives

Synthesis, Optoelectronic and Self‐Assembly Properties of Diazadioxaacene Derivatives

Light‐Induced PEGylation and Functionalization of Semiconductor Polymer Dots

A Multiple‐Stimulus‐Responsive Biomimetic Assembly Based on a Polyisocyanopeptide and Conjugated Polymer

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