Near Infrared (NIR) absorbing dyes as promising photosensitizer for photo dynamic therapy

P, Chinna Ayya Swamy; Sivaraman, Gandhi; Priyanka, Ragam N.; Raja, Sufi O.; Ponnuvel, Kandhasamy; Shanmugpriya, Jeyabalan; Gulyani, Akash

doi:10.1016/j.ccr.2020.213233

Cited by 202 publications

(113 citation statements)

References 154 publications

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“…Recently, research on the development of a robust system for the delivery of photosensitizers towards cancer tissue has been actively conducted [ 11 , 76 , 77 ]. Particularly, the surface-specific modification of photosensitizers using biomolecules, such as proteins, peptides, nucleic acids, or supramolecular architectures of photosensitizers, including dendrimers, micelles, and liposomes, is being well studied [ 78 , 79 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the important properties of photosensitizers that need to be considered include low toxicity in the absence of photo-irradiation and high accumulation rate in cancer tissues ( Figure 1 ) [ 8 , 9 ]. The main reason for the high accumulation rate of photosensitizers in cancer tissues is their high affinity towards low-density lipoprotein receptors (LDLRs), which are overexpressed in most of the cancer cells [ 10 , 11 ].…”

Section: Photodynamic Therapy For Cancermentioning

confidence: 99%

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Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy

Kawauchi

Urano

Kinoshita

et al. 2020

Genes

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G-quadruplex (G4) is the non-canonical secondary structure of DNA and RNA formed by guanine-rich sequences. G4-forming sequences are abundantly located in telomeric regions and in the promoter and untranslated regions (UTR) of cancer-related genes, such as RAS and MYC. Extensive research has suggested that G4 is a potential molecular target for cancer therapy. Here, we reviewed G4 ligands as photosensitizers for cancer photodynamic therapy (PDT), which is a minimally invasive therapeutic approach. The photosensitizers, such as porphyrins, were found to be highly toxic against cancer cells via the generation of reactive oxidative species (ROS) upon photo-irradiation. Several porphyrin derivatives and analogs, such as phthalocyanines, which can generate ROS upon photo-irradiation, have been reported to act as G4 ligands. Therefore, they have been implicated as promising photosensitizers that can selectively break down cancer-related DNA and RNA forming G4. In this review, we majorly focused on the potential application of G4 ligands as photosensitizers, which would provide a novel strategy for PDT, especially molecularly targeted PDT (mtPDT).

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Section: Discussionmentioning

confidence: 99%

Section: Photodynamic Therapy For Cancermentioning

confidence: 99%

Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy

Kawauchi

Urano

Kinoshita

et al. 2020

Genes

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“…Photodynamic therapy (PDT) is a non-invasive, precise cancer therapy possessing several advantages in comparison to other cancer treatments. Very briefly, this therapy is based on the use of photo-sensitizers (PS) that when specifically excited generate cytotoxic ROS that cause cell death, general features of PDT have been discussed in recent review articles [ 210 , 211 , 212 , 213 , 214 ]. Considered this, the choice of the suitable light sources and the presence of oxygen in the target tissues are fundamental issues for the efficacy of the therapy.…”

Section: Mnp Based Therapy and Theranosticsmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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“…NMR spectra were measured on a Bruker Avance 500 spectrometer ( 1 H: 500 MHz, 13 C: 126 MHz, 11 B: 160 MHz, 19 F: 471 MHz) and JEOL JMN-ECS400 ( 1 H; 400 MHz, 11 B; 128 MHz). In 1 H and 13 C NMR measurements, chemical shifts (δ) are reported downfield from the internal standard Me 4 Si. BF 3 .…”

Section: Generalmentioning

confidence: 99%

Asymmetrical benzo[a]-fused N₂O₂-boron-chelated BODIPYs as red to near-infrared absorbing chromophores: synthesis, characteristics and device applications for opto-electronics

et al. 2021

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Near Infrared (NIR) absorbing dyes as promising photosensitizer for photo dynamic therapy

Cited by 202 publications

References 154 publications

Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy

Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Asymmetrical benzo[a]-fused N₂O₂-boron-chelated BODIPYs as red to near-infrared absorbing chromophores: synthesis, characteristics and device applications for opto-electronics

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Near Infrared (NIR) absorbing dyes as promising photosensitizer for photo dynamic therapy

Cited by 202 publications

References 154 publications

Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy

Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Asymmetrical benzo[a]-fused N2O2-boron-chelated BODIPYs as red to near-infrared absorbing chromophores: synthesis, characteristics and device applications for opto-electronics

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Asymmetrical benzo[a]-fused N₂O₂-boron-chelated BODIPYs as red to near-infrared absorbing chromophores: synthesis, characteristics and device applications for opto-electronics