Near-infrared optical nanothermometry via upconversion of Ho3+-sensitized nanoparticles

Ryszczyńska, Sylwia; Martín, Inocencio R.; Grzyb, Tomasz

doi:10.1038/s41598-023-42034-z

Cited by 5 publications

(1 citation statement)

References 52 publications

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“…Though it is weaker than in a system with only Ho 3+ ions, the emission from Ho 3+ ions at 890 and 743 nm is caused by energy transfer from the excited Er 3+ ions. This unique property showcased a relative sensitivity reaching its peak value of 1.80% K −1 at 378 K. These findings underscore the exceptional optical temperature sensing capabilities of the NaYF 4 :Ho 3+ , Er 3+ @NaYF 4 system, mainly relying on the luminescence intensity ratios of the near-infrared bands associated with both Ho 3+ and Er 3+ ions [164].…”

Section: Fir Between Moderately Coupled Levelsmentioning

confidence: 59%

Advances in Synthesis Strategies for Lanthanide-based NaYF4 Upconversion Nanocrystals and Their Applications in Ratiometric Thermometry

Janjua,

Ji,

Shah

et al. 2023

PIER M

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The optical characteristics and varied applications of lanthanide-doped NaYF4 upconversion nanocrystals have received considerable interest in recent years, such as in ratiometric thermometry. This review thoroughly examines the various synthesis processes utilized in producing these nanocrystals and their application in temperature sensing. Synthesis of NaYF4 upconversion nanocrystals is a complex procedure that requires careful management of dopant concentrations, crystal phase, size, and shape. The distinctive luminescent characteristics of lanthanide ions, which facilitate the transformation of photons with low energy into emissions with higher energy, render NaYF4 nanocrystals suitable for ratiometric thermometry applications. We explore the fundamental concepts underlying upconversion luminescence in developing ratiometric temperature sensors. In this discourse, we examine the selection of lanthanide dopants, the mechanics underlying their energy transmission, and the development of customized sensor architectures. This review covers the recent progress and utilization of NaYF4 upconversion nanocrystals in ratiometric thermometry, including diverse areas such as biological temperature detection, environmental surveillance, and materials research. We evaluate the obstacles and potential advancements in this domain, specifically emphasizing approaches to improving temperature sensors' precision, responsiveness, and applicability based on upconversion.

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Section: Fir Between Moderately Coupled Levelsmentioning

confidence: 59%

Advances in Synthesis Strategies for Lanthanide-based NaYF4 Upconversion Nanocrystals and Their Applications in Ratiometric Thermometry

Janjua,

Ji,

Shah

et al. 2023

PIER M

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New Horizons for Temperature Sensing and Bioimaging Using Er³⁺‐Doped Core@Shell Nanoparticles and Effects of H₂O and D₂O Solvents on Their Spectroscopic Properties

Ryszczyńska,

Soler‐Carracedo,

Ekner‐Grzyb

et al. 2024

Advanced Optical Materials

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Lanthanide‐doped nanoparticles (NPs) exhibit temperature‐dependent luminescence, enabling the design of luminescent nanothermometers for industrial and medical applications. This research demonstrates the temperature‐sensing properties of NaYF4:7.5%Er3+@NaYF4 and NaErF4@NaYF4 NPs, which have a hexagonal shape and average size of 17 nm. Their core@shell structure is confirmed using high‐resolution transmission electron microscopy, and they exhibit intense upconversion (UC) emission under 1532 nm excitation in H2O and D2O colloids. The recorded spectra show Er3+ emission bands with varying intensity ratios depending on the Er3+ concentration, chosen solvent, and temperature. The spectroscopic properties of the studied NPs allow for their excitation and observation of emission within biological windows, which makes them useful for bio‐related applications. The emission of prepared NPs is analyzed as a function of temperature from 298 up to 358/363 K in H2O and D2O. The ratios for thermally‐coupled levels and non‐TCLs and their relative sensitivities are studied. For the high dopant concentration sample in water, the O─H vibrations and blue shift in the absorption spectrum lead to a record relative sensitivity of 2.50% K−1 (at 363 K) for the 2H11/2/4I11/2 ratio. The use of synthesized NPs for bioimaging under 1550 nm excitation is also demonstrated to observe their accumulation in the guts of Daphnia magna.

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Ultrasensitive and Adjustable Nanothermometers Based on Er³⁺-Sensitized Core@Shell Nanoparticles for Use in the First Biological Window

Grzyb,

Ryszczyńska,

Jurga

et al. 2024

ACS Appl. Mater. Interfaces

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In recent years, intensive research has focused on lanthanide-doped nanoparticles (NPs) used as noncontact temperature sensors, particularly in nanomedicine. These NPs must be capable of excitation and emission within biological windows, where biological materials usually show better transparency for radiation. In this article, we propose that NPs sensitized with Er 3+ ions can be applied as temperature sensors in biological materials. We synthesized the NPs through a reaction in high-boiling solvents and confirmed their crystal structure and the formation of core@ shell NPs by using X-ray diffraction, high-resolution transmission electron microscopy, and element distribution mapping within the NPs. NaErF 4 @NaYF 4 , NaYF 4 :12.5% Er 3+ , 2.5% Tm 3+ @NaYF 4 , NaYF 4 :7.5% Er 3+ @NaYF 4 , and NaYF 4 :12.5% Er 3+ , 2.5% Ho 3+ @ NaYF 4 exhibited intense upconversion (UC) emission under 1532 nm laser excitation detectable also in the whole human blood. We propose that this UC results from energy transfer between Er 3+ ions and from Er 3+ to Tm 3+ or Ho 3+ codopants. To determine the mechanism of UC, we measured the dependence of the emission band intensities on the laser power densities. Importantly, we also analyzed the temperature-dependent emission of the NPs within the 295−360 K range. Based on the collected emission spectra, we calculated the luminescence intensity ratios (LIRs) of the emission bands to assess their potential for optical temperature sensing. The temperature-sensing properties varied with the concentration of Er 3+ ions and the presence of additional Tm 3+ or Ho 3+ codopants. Depending on the NP composition and the emission bands used for luminescence ratio calculations, the maximum relative temperature sensitivity ranged from 4.55%•K −1 to 1.12%•K −1 , with temperature resolution between 0.05 and 2.53 K at room temperature. Finally, as proof of using NPs as temperature sensors in biomedicine, we successfully measured the temperaturedependent emission of NaYF 4 :7.5% Er 3+ @NaYF 4 NPs dispersed in whole blood under 1532 nm excitation. We demonstrated that the ratio of Er 3+ ion emission bands changes with temperature, indicating that these NPs have potential applications in temperature sensing within biological environments. We also confirmed the properties of NPs as temperature sensors by measuring the temperature reading uncertainty and the repeatability of the LIR readings during heating−cooling cycles, thereby confirming the excellent properties of the studied systems as temperature sensors.

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Near-infrared optical nanothermometry via upconversion of Ho3+-sensitized nanoparticles

Cited by 5 publications

References 52 publications

Advances in Synthesis Strategies for Lanthanide-based NaYF4 Upconversion Nanocrystals and Their Applications in Ratiometric Thermometry

Advances in Synthesis Strategies for Lanthanide-based NaYF4 Upconversion Nanocrystals and Their Applications in Ratiometric Thermometry

New Horizons for Temperature Sensing and Bioimaging Using Er³⁺‐Doped Core@Shell Nanoparticles and Effects of H₂O and D₂O Solvents on Their Spectroscopic Properties

Ultrasensitive and Adjustable Nanothermometers Based on Er³⁺-Sensitized Core@Shell Nanoparticles for Use in the First Biological Window

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Near-infrared optical nanothermometry via upconversion of Ho3+-sensitized nanoparticles

Cited by 5 publications

References 52 publications

Advances in Synthesis Strategies for Lanthanide-based NaYF4 Upconversion Nanocrystals and Their Applications in Ratiometric Thermometry

Advances in Synthesis Strategies for Lanthanide-based NaYF4 Upconversion Nanocrystals and Their Applications in Ratiometric Thermometry

New Horizons for Temperature Sensing and Bioimaging Using Er3+‐Doped Core@Shell Nanoparticles and Effects of H2O and D2O Solvents on Their Spectroscopic Properties

Ultrasensitive and Adjustable Nanothermometers Based on Er3+-Sensitized Core@Shell Nanoparticles for Use in the First Biological Window

Contact Info

Product

Resources

About

New Horizons for Temperature Sensing and Bioimaging Using Er³⁺‐Doped Core@Shell Nanoparticles and Effects of H₂O and D₂O Solvents on Their Spectroscopic Properties

Ultrasensitive and Adjustable Nanothermometers Based on Er³⁺-Sensitized Core@Shell Nanoparticles for Use in the First Biological Window