Near-infrared photochemistry at interfaces based on upconverting nanoparticles

Wu, Si; Butt, Hans‐Jürgen

doi:10.1039/c7cp01838j

Cited by 55 publications

(37 citation statements)

References 123 publications

(162 reference statements)

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“…However, the absorption tails but not the peaks of the reported compounds just reach the NIR region. Although the two-photon process 28,29 and upconversion-assisted photochemistry 18,[30][31][32][33][34][35][36][37][38] can activate Ru complexes using NIR light, both methods are based on inefficient nonlinear optical processes. Two-photon absorption requires unsafe high-intensity laser excitation and only occurs at the focus of pulsed lasers.…”

Section: Discussionmentioning

confidence: 99%

Photoresponsive ruthenium-containing polymers: potential polymeric metallodrugs for anticancer phototherapy

Sun

Zeng

2018

Dalton Trans.

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This Frontier presents the recent development of photoresponsive Ru-containing polymers for cancer treatment. These novel Ru-containing polymers are prepared by introducing photoresponsive Ru complexes into polymers. Based on their chemical structures in aqueous solutions, these polymers can self-assemble into different nanostructures. The self-assembled nanostructures can circulate in the blood stream, accumulate at tumor tissue, and can be taken up by tumor cells. Red light, which can penetrate into tissue deeply, can induce the photodissociation of these polymers and sensitize singlet oxygen (O) generation. Both dissociated Ru complexes and generated O can inhibit the growth of tumor cells. Photoresponsive Ru-containing polymers provide a new platform for combined photodynamic therapy and photoactivated chemotherapy. The design strategies, self-assembly, photoresponsiveness, and anticancer effects of these polymers are introduced. Some remaining challenges for Ru-containing polymers for phototherapy are discussed.

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Section: Discussionmentioning

confidence: 99%

Photoresponsive ruthenium-containing polymers: potential polymeric metallodrugs for anticancer phototherapy

Sun

Zeng

2018

Dalton Trans.

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“…Even though NIR light can penetrate deeper than UV and visible light, it can only reach around a 3 cm deep in tissue. 41 Due to the finite tissue penetration of NIR light in deep tissues, it is a great challenge for PTT alone to eradicate metastatic cancer cells or metastatic nodules in distant organs. 42 Accordingly, it is necessary to combine PTT with current available therapies for a desired efficacy on cancer metastasis (Figure 1).…”

Section: Combination Of Ptt With Cht Rt It and Pdtmentioning

confidence: 99%

<p>Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment</p>

Wang¹,

Wu²,

Shen³

et al. 2020

IJN

165

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Background: Cancer is one of the major causes of death and is difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) and immunotherapy (IT)] are widely used but they have limited therapeutic effects and unavoidable side effects. Recently, the development of novel nanomaterials offers a platform for combinational therapy (meaning a combination of two or more therapeutic agents) which is a promising approach for cancer therapy. Recent studies have demonstrated several types of nanomaterials suitable for photothermal therapy (PTT) based on a near-infrared (NIR) light-responsive system. PTT possesses favorable properties such as being low in cost, and having high temporospatial control with minimal invasiveness. However, short NIR light penetration depth limits its functions. Methods: In this review, due to their promise, we focus on inorganic nanomaterials [such as hollow mesoporous silica nanoparticles (HMSNs), tungsten sulfide quantum dots (WS 2 QDs), and gold nanorods (AuNRs)] combining PTT with CHT, RT or IT in one treatment, aiming to provide a comprehensive understanding of PTT-based combinational cancer therapy. Results: This review found much evidence for the use of inorganic nanoparticles for PTTbased combinational cancer therapy. Conclusion: Under synergistic effects, inorganic nanomaterial-based combinational treatments exhibit enhanced therapeutic effects compared to PTT, CHT, RT, IT or PDT alone and should be further investigated in the cancer field.

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“…Coupling the trapping setup to optical fibers and optimizing the coupling at the desired wavelengths are of interest to this application. [83,121] Once trapped, the stable immobilization of the emitter in the aperture may be achieved by one of many photochemical processes, [122] photothermal processes, or even steric immobilization.…”

Section: Quantum Emittersmentioning

confidence: 99%

Metal Nanoapertures and Single Emitters

Gordon

2020

Advanced Optical Materials

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"shrink" the wavelength of light. The finite permittivity also allows for penetration of the field into the metal. These factors can increase the cut off so that apertures much smaller than half the wavelength can have propagating modes. [6] In addition to rectangular apertures, [7] various shapes have been investigated for having higher transmission such as c-shape, [8] bow-tie, [9] and double nanoholes. [10,11] The shaping of apertures allows for further localizing the field to a "hot spot," thereby reducing the interaction volume. Those works have shown that apertures in real metals can dramatically reduce the interaction volume to the single digit nanometer scale, comparable to single molecules or nanoparticles. [12] Metal nanostructures have been studied extensively for enhancing the interaction with single emitters. [14] These studies seem to be predominantly focused on isolated nanostructures made of metal, rather than apertures. Apertures in metal films offer several features that benefit interaction with single emitters (Figure 1): Nanoapertures in metal films have long been recognized for their ability to confine light to subwavelength dimensions. This allows for high-resolution imaging of single emitters with enhanced emission rates. It also provides a background-free environment that has been exploited for biophysical applications like fluorescence correlation studies at high physiological concentrations and DNA sequencing. Recently, other advantages of single apertures have been recognized, including optical trapping, thermal management, and nanofluidic (nanopore) functionality. This paper reviews metal nanoapertures and their applications to single emitter studies for biophysical and quantum applications.

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Near-infrared photochemistry at interfaces based on upconverting nanoparticles

Cited by 55 publications

References 123 publications

Photoresponsive ruthenium-containing polymers: potential polymeric metallodrugs for anticancer phototherapy

Photoresponsive ruthenium-containing polymers: potential polymeric metallodrugs for anticancer phototherapy

<p>Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment</p>

Metal Nanoapertures and Single Emitters

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