Near-infrared photoimmunotherapy and anti-cancer immunity

Nakajima, Kohei; Ogawa, Mikako

doi:10.1093/intimm/dxad042

Cited by 3 publications

(2 citation statements)

References 81 publications

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“…Near-infrared photoimmunotherapy (NIT-PIT) is another promising cancer therapy method with lower side effects [64,65]. This method is based on monoclonal antibodyphoton absorber conjugate (APC) [66].…”

Section: Sv-oct In Therapeutic Assessments Of Various Medical Treatmentsmentioning

confidence: 99%

“…Nevertheless, the technical functionality of the system has to be further enhanced to overcome the limitations of imaging artifacts by optimizing the repetition rate of B-scans. Near-infrared photoimmunotherapy (NIT-PIT) is another promising cancer therapy method with lower side effects [64,65]. This method is based on monoclonal antibodyphoton absorber conjugate (APC) [66].…”

Section: Sv-oct In Therapeutic Assessments Of Various Medical Treatmentsmentioning

confidence: 99%

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Growing Trend to Adopt Speckle Variance Optical Coherence Tomography for Biological Tissue Assessments in Pre-Clinical Applications

Wijesinghe,

Kahatapitiya,

Lee

et al. 2024

Micromachines

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Speckle patterns are a generic feature in coherent imaging techniques like optical coherence tomography (OCT). Although speckles are granular like noise texture, which degrades the image, they carry information that can be benefited by processing and thereby furnishing crucial information of sample structures, which can serve to provide significant important structural details of samples in in vivo longitudinal pre-clinical monitoring and assessments. Since the motions of tissue molecules are indicated through speckle patterns, speckle variance OCT (SV-OCT) can be well-utilized for quantitative assessments of speckle variance (SV) in biological tissues. SV-OCT has been acknowledged as a promising method for mapping microvasculature in transverse-directional blood vessels with high resolution in micrometers in both the transverse and depth directions. The fundamental scope of this article reviews the state-of-the-art and clinical benefits of SV-OCT to assess biological tissues for pre-clinical applications. In particular, focus on precise quantifications of in vivo vascular response, therapy assessments, and real-time temporal vascular effects of SV-OCT are primarily emphasized. Finally, SV-OCT-incorporating pre-clinical techniques with high potential are presented for future biomedical applications.

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Section: Sv-oct In Therapeutic Assessments Of Various Medical Treatmentsmentioning

confidence: 99%

Section: Sv-oct In Therapeutic Assessments Of Various Medical Treatmentsmentioning

confidence: 99%

Growing Trend to Adopt Speckle Variance Optical Coherence Tomography for Biological Tissue Assessments in Pre-Clinical Applications

Wijesinghe,

Kahatapitiya,

Lee

et al. 2024

Micromachines

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Photosensitizers in photodynamic therapy: An advancement in cancer treatment

Oluwajembola,

Cleanclay,

Onyia

et al. 2024

Results in Chemistry

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Therapeutic Host Anticancer Immune Response through Photoimmunotherapy for Head and Neck Cancer May Overcome Resistance to Immune Checkpoint Inhibitors

Koyama,

Ehara,

Donishi

et al. 2024

Case Rep Oncol

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Introduction: Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed hybrid cancer therapy that directly kills cancer cells while producing a therapeutic host anticancer immune response. The activation of host immunity using NIR-PIT can enhance the effects of immune checkpoint inhibitors (ICIs) in animal experimental models; however, there have been no reports of this phenomenon in humans. Furthermore, by activating host immunity using NIR-PIT in patients who have become resistant to ICIs, the effects of ICIs can be restored. Case Presentation: A 56-year-old male experienced local recurrence after chemoradiotherapy for maxillary sinus cancer (cT4bN0M0). The disease had progressed following ICI antiPD-1 antibody therapy. He underwent NIR-PIT for four cycles; however, a local recurrent tumor remained and began a rapid regrowth. The ICI antiPD-1 antibody was then readministered following NIR-PIT. As a result, sensitivity to antiPD-1 therapy was restored, and the tumor shrank. Finally, a complete response was observed without major adverse events associated with subsequent antiPD-1 antibody treatment following NIR-PIT. Conclusion: These results indicated that NIR-PIT may not only activate host anticancer immunity but also enhance the effects of ICIs and overcome antiPD-1 resistance.

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Near-infrared photoimmunotherapy and anti-cancer immunity

Cited by 3 publications

References 81 publications

Growing Trend to Adopt Speckle Variance Optical Coherence Tomography for Biological Tissue Assessments in Pre-Clinical Applications

Growing Trend to Adopt Speckle Variance Optical Coherence Tomography for Biological Tissue Assessments in Pre-Clinical Applications

Photosensitizers in photodynamic therapy: An advancement in cancer treatment

Therapeutic Host Anticancer Immune Response through Photoimmunotherapy for Head and Neck Cancer May Overcome Resistance to Immune Checkpoint Inhibitors

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