Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications

Paraboschi, Irene; Turnock, Stephen; Kramer‐Marek, Gabriela; Musleh, Layla; Barisa, Marta; Anderson, John; Giuliani, Stefano

doi:10.1016/j.critrevonc.2021.103325

Cited by 18 publications

(18 citation statements)

References 63 publications

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“…Several other probes based on cyanine scaffolds and other fluorophores are in preclinical and clinical trials for phototherapy [ 152 , 154 ]. Among these photosensitizers, IR700-DX, a silicon-phthalocyanine-based dye, has shown promising therapeutic properties upon conjugation to antibodies [ 155 , 156 , 157 , 158 ] or to PSMA-targeting ligands [ 159 , 160 ] and has recently advanced in a range of clinical studies [ 161 , 162 ]. For dual-modal labeling, Rijpkema and coworkers developed a multi-modal PSMA-targeting agent by labeling an anti-PSMA mAb (D2B) with IR700-DX and 111 In ( Figure 4 c) [ 155 ].…”

Section: Future Directions Of Dual-modal Imagingmentioning

confidence: 99%

Targeted Dual-Modal PET/SPECT-NIR Imaging: From Building Blocks and Construction Strategies to Applications

Usama

Marker

Vargas

et al. 2022

Cancers

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Molecular imaging is an emerging non-invasive method to qualitatively and quantitively visualize and characterize biological processes. Among the imaging modalities, PET/SPECT and near-infrared (NIR) imaging provide synergistic properties that result in deep tissue penetration and up to cell-level resolution. Dual-modal PET/SPECT-NIR agents are commonly combined with a targeting ligand (e.g., antibody or small molecule) to engage biomolecules overexpressed in cancer, thereby enabling selective multimodal visualization of primary and metastatic tumors. The use of such agents for (i) preoperative patient selection and surgical planning and (ii) intraoperative FGS could improve surgical workflow and patient outcomes. However, the development of targeted dual-modal agents is a chemical challenge and a topic of ongoing research. In this review, we define key design considerations of targeted dual-modal imaging from a topological perspective, list targeted dual-modal probes disclosed in the last decade, review recent progress in the field of NIR fluorescent probe development, and highlight future directions in this rapidly developing field.

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Section: Future Directions Of Dual-modal Imagingmentioning

confidence: 99%

Targeted Dual-Modal PET/SPECT-NIR Imaging: From Building Blocks and Construction Strategies to Applications

Usama

Marker

Vargas

et al. 2022

Cancers

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“…Clinical trials of NIR‐PIT have been in Phase 1/2/3 globally since 2015 (Table 2). The first clinical study of NIR‐PIT was completed in 2019 using the target antibody cetuximab saratolacan (cetuximab conjugated to IR700, also known as RM‐1929) to target EFGR in patients with recurrent head and neck cancer to demonstrate its safety and efficacy (NCT02422979) 85,86 . Head and neck squamous cell carcinoma is located at the base of the head where it connects to the neck, and is the sixth most common cancer globally 87 .…”

Section: Nir‐pit Clinical Studiesmentioning

confidence: 99%

Quickly evolving near‐infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment

Monaco

Yokomizo

Choi

et al. 2021

VIEW

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Among modalities of cancer immunotherapy, near-infrared photoimmunotherapy (NIR-PIT) has reached significant preclinical and clinical stages and quickly evolved over the last 5 years. NIR-PIT uses deep-penetrable NIR light to induce physicochemical changes in the antibody-photosensitizer conjugate (APC), leading to resultant necrosis and immunogenic cell death (ICD) of the cancer cells. Alternatively, other types of photomedicine use photosensitizers to convert absorbed light energy either into reactive oxygen species for photodynamic therapy (PDT) or into heat for photothermal therapy (PTT). ICD is a unique and relevant outcome of NIR-PIT because it induces long-lasting antitumor host immunity, which overcomes the immunosuppressive network of cancer. Due to its high specificity and durable antitumor effects, NIR-PIT is now considered a promising cancer therapy, and optimized NIR-PIT is readily expanding its applicability to many different types of cancer. Along with the traditional method of NIR-PIT, new avenues in its realm of treatment are currently being explored, such as the targeting of other immunosuppressive elements, delivery of NIR light through a catheter, real-time imaging for tumor detection, and the use of tumor-seeking small molecules for improved efficacy and safety. In addition, its effect on hyperpermeability has opened a door for a wide array of combination therapies with other modalities. This review summarizes the recent findings in clinical and preclinical studies of NIR-induced photomedicine and its future significance in the field of cancer research.

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“…Photodynamic therapy (PDT), for example, can be used as treatment, salvage therapy, and palliative care for different tumours. However, PDT is, in general, a non-selective treatment acting on both healthy and cancerous cells ( 76 ). This limit can be overcome by using near-infrared photoimmunotherapy (NIR-PIT) that selectively kill cancer cells due to the conjugation of a special fluorophore with a monoclonal antibody.…”

Section: Intra-operative Loco-regional Treatmentsmentioning

confidence: 99%

“…From the wide range of therapies available in oncologic patients, PDT represents a novel adjuvant treatment capable of consolidating loco-regional control, aiming to reduce metastatic spread and progression of the tumour. The principle of PDT is a photochemical reaction between a photosensitive molecule (photosensitiser), light and molecular oxygen ( 76 , 79 ). Administration of PDT starts with the intravenous, intraperitoneal or topical administration of a photosensitiser, followed by light exposure, which leads to the creation of radicals ( Figure 3 ) ( 80 ).…”

Section: Intra-operative Loco-regional Treatmentsmentioning

confidence: 99%

Above and Beyond Robotic Surgery and 3D Modelling in Paediatric Cancer Surgery

et al. 2021

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Although the survival rates for children's cancers have more than doubled in the last few decades, the surgical practise has not significantly changed. Among the most recent innovations introduced in the clinic, robotic surgery and augmented reality are two of the most promising, even if they are not widespread. The increased flexibility of the motion, the magnification of the surgical field and the tremor reduction provided by robotic surgery have been beneficial to perform complex oncological procedures in children. Besides, augmented reality has been proven helpful in planning for tumour removal, facilitating early discrimination between cancer and healthy organs. Nowadays, research in the field of surgical oncology is moving fast, and new technologies and innovations wich will help to shape a new way to perform cancer surgery. Paediatric surgeons need to be ready to adopt these novel devices and intraoperative techniques to allow more radical tumour resections with fewer complications. This review aims to present the mechanism of action and indications of several novel technologies such as optical imaging surgery, high definition cameras, and intraoperative loco-regional treatments. We hope this will enhance early adoption and more research on how to employ technology for the benefit of children.

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Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications

Cited by 18 publications

References 63 publications

Targeted Dual-Modal PET/SPECT-NIR Imaging: From Building Blocks and Construction Strategies to Applications

Targeted Dual-Modal PET/SPECT-NIR Imaging: From Building Blocks and Construction Strategies to Applications

Quickly evolving near‐infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment

Above and Beyond Robotic Surgery and 3D Modelling in Paediatric Cancer Surgery

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