Near-Infrared Plasmon-Boosted Heat/Oxygen Enrichment for Reversing Rheumatoid Arthritis with Metal/Semiconductor Composites

Wang, Shasha; Chen, Ronghe; Qian, Yu; Huang, Wenchao; Lai, Puxiang; Jianxin, Tang; Nie, Liming

doi:10.1021/acsami.0c13261

Cited by 59 publications

(47 citation statements)

References 61 publications

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“…In addition to the strategies mentioned above, new research fields have arisen, including chondroprotective treatment, usage of lubricants, [ 140 ] nano‐enzymes, [ 141,142 ] cell membrane‐coated nanoparticles, [ 143 ] and immunization therapy. Moreover, improving the sensitivity and specificity of stimuli‐responsive/scavenging materials to match the biological concentrations of functional substances such as ROS and enzymes should be paid much attention.…”

Section: Discussionmentioning

confidence: 99%

Stimuli‐Sensitive Nanotherapies for the Treatment of Osteoarthritis

Wang

et al. 2021

Macromolecular Bioscience

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Osteoarthritis (OA) is a common chronic inflammatory disease in the joints. It is one of the leading causes of disability with increasing morbidity, which has become one of the serious clinical issues. Current treatments would only provide temporary relief due to the lack of early diagnosis and effective therapy, and thus the replacement of joints may be needed when the OA deteriorates. Although the intra‐articular injection and oral administration of drugs are helpful for OA treatment, they are suffering from systemic toxicity, short retention time in joint, and insufficient bioavailability. Nanomedicine is potential to improve the drug delivery efficiency and targeting ability. In this focused progress review, the particle‐based drug loading systems that can achieve targeted and triggered release are summarized. Stimuli‐responsive nanocarriers that are sensitive to endogenous microenvironmental signals such as reactive oxygen species, enzymes, pH, and temperature, as well as external stimuli such as light for OA therapy are introduced in this review. Furthermore, the nanocarriers associated with targeted therapy and imaging for OA treatment are summarized. The potential applications of nanotherapies for OA treatment are finally discussed.

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Section: Discussionmentioning

confidence: 99%

Stimuli‐Sensitive Nanotherapies for the Treatment of Osteoarthritis

Wang

et al. 2021

Macromolecular Bioscience

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“…They confirmed the RA-induced lesions were improved after the intraarticular injection at day 28 in the mouse model. [78] A few microparticle formulations are currently in the early stages of clinical development. In a phase 2 open-label study, an i.a.…”

Section: Microparticle Delivery Systemsmentioning

confidence: 99%

Nanomedicine Strategies for Anti‐Inflammatory Treatment of Noninfectious Arthritis

Chen

Wang

Lee

et al. 2021

Adv Healthcare Materials

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Noninfectious arthritis (NIA) comprises a class of chronic and progressive inflammatory disorders that require early-stage management to prevent disease progression. The most common forms include osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and gouty arthritis. Current treatments involve nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs and glucocorticoids to alleviate clinical symptoms, although regular use of these can result in a high risk of chronic kidney disease and heart failure, as well as severe adverse gastrointestinal effects. Nanomedicine offers unique opportunities to address these challenges and improve therapeutic efficacy due to its ability to deliver therapeutics locally in a sustained manner, thus extending the half-life, improving bioavailability, and reducing the side effects of these agents. This review includes a comprehensive analysis of the mechanisms of various treatment options for NIA and highlights recent progress and emerging strategies in treating NIA with nanomedicine platforms, particularly related to long-term biosafety and nonspecific targeting in designing nanomedicine delivery systems.

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“…A mouse RA model was then employed to further demonstrate the application of HQ for imaging of HOCl-mediated inammation response. Mouse RA model of le hind limb was obtained using previously reported procedure, 50,51 and the right hind limb was treated with PBS as the control group. HQ was injected into both the hind limbs at the same area, and then images were recorded immediately aer injection.…”

Section: Fluorescence Imaging Of Hocl In Live Animalsmentioning

confidence: 99%