Near-Infrared Polymer Dots with Aggregation-Induced Emission for Tumor Imaging

Zhang, Zhe; Chen, Dandan; Liu, Zhihe; Wang, Dan; Guo, Jintong; Zheng, Jie; Qin, Weiping; Wu, Changfeng

doi:10.1021/acsapm.9b00977

Cited by 29 publications

(24 citation statements)

References 39 publications

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“…Structural imaging of tumors is also gaining the interest of researchers for its crucial role in exploring the mechanisms of tumorigenesis as well as the diagnosis and treatment of tumors. Currently, NIR-II imaging has been extensively used in early diagnosis of tumors with a high tumor-to-background ratio (TBR). ,− More recently, the development of multi-channel NIR-II imaging and the 3D light-sheet imaging techniques has greatly promoted assays of tumor structure. In 2018, Wan et al obtained the 3D structure of 4T1 tumors in living mice by two-channel NIR-II confocal microscopy .…”

Section: Recent Advances Of Nir-ii Fluorescence Imaging In Biomedical...mentioning

confidence: 99%

Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

et al. 2020

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Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital imaging capacity in the conventional wavelength range (400−950 nm) has been restricted by its extremely limited tissue penetration. To tackle this challenge, a novel imaging approach using the fluorescence in the second near-infrared window (NIR-II, 1000−1700 nm) has been developed in the past decade to achieve deep penetration and high-fidelity imaging, and thus significant biomedical applications have begun to emerge. In this Perspective, we first examine recent discoveries and challenges in the development of novel NIR-II fluorophores and compatible imaging apparatuses. Subsequently, the recent advances in bioimaging, biosensing, and therapy using such a cutting-edge imaging technique are highlighted. Finally, based on the achievement in the representative studies, we elucidate the main concerns regarding this imaging technique and give some advice and prospects for the development of NIR-II imaging for future biomedical applications.

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Section: Recent Advances Of Nir-ii Fluorescence Imaging In Biomedical...mentioning

confidence: 99%

Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

et al. 2020

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“…Recently, Wu and coworkers [16] reported NIR emissive AIE conjugated polymers PBT with high fluorescence QY (Figure 3c). After fabricating PBT into Pdots, the fluorescence QYs were further improved from 9 % to 23 % (Figure 3d).…”

Section: Applications Of Aie Conjugated Polymersmentioning

confidence: 92%

Conjugated Polymers with Aggregation‐Induced Emission Characteristics for Fluorescence Imaging and Photodynamic Therapy

Wang

Qin

et al. 2021

ChemMedChem

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Accurate diagnosis and treatment have been extensively developed in the field of biomedicine, which put forward higher requirements for the development of biomedical materials with high efficiency and selectivity. Among them, conjugated polymers featuring aggregation‐induced emission (AIE) characteristics (AIE conjugated polymers) have stood out in recent years owing to their unique properties, such as intense solid emission, high light‐harvesting ability, efficient energy transfer, and high 1O2 generation ability, which empower them with effective biomedical functions in fluorescence imaging (FLI), photodynamic therapy (PDT), FLI‐guided PDT, two‐photon excited photodynamic therapy (2PE‐PDT), etc. In this review, we highlight recent progress in AIE conjugated polymers and their applications in anticancer and antibacterial areas based on FLI and PDT, and summarize the mechanism of color‐tuned fluorescence emission and efficient 1O2 generation ability. The challenges and perspectives for the future development of AIE conjugated polymers are also discussed.

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“…For instance, the perturbation relaxation between aggregated chains will lead to a decrease of the luminous efficiency of Pdots, while after introducing the AIE group, the luminous efficiency of stacked nanoparticles does not decrease but increases. 37 Generally, Pdots are nanoparticles with a size of nanometers and they contain more than 50% conjugated polymer by weight. In other words, the conjugated polymer is the main material of Pdots, and the properties of the conjugated polymer also affect the properties of Pdots, which poses various possibilities and challenges for their biological applications.…”

Section: Basic Properties Of Pdotsmentioning

confidence: 99%