Near‐infrared responsive targeted drug delivery system that offer chemo‐photothermal therapy against bacterial infection

Patel, Unnati; Rathnayake, Kavini; Jani, Hemang; Jayawardana, Kalana W.; Dhakal, Rijan R.; Duan, Lingze; Jayawardena, H. Surangi N.

doi:10.1002/nano.202000271

Cited by 15 publications

(30 citation statements)

References 52 publications

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“…Patel and co-authors developed a nanocomposite consisting of AuNRs coated with mesoporous silica. 218 This complex played a role of nanocarrier onto which the antituberculotic medicine, bedaquiline (BDQ), was loaded. The entire composite was wrapped in thermo-sensitive liposomes (TSLs) under the name GNR@MSNP@BDQ@TSL@NZX with NZX responsible for the bond between the nanocomposite and mycobacteria.…”

Section: Photothermal Therapymentioning

confidence: 99%

Emerging Trends in Nanomaterials for Antibacterial Applications

Yougbaré¹,

Mutalik²,

Okoro³

et al. 2021

IJN

127

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Around the globe, surges of bacterial diseases are causing serious health threats and related concerns. Recently, the metal ion release and photodynamic and photothermal effects of nanomaterials were demonstrated to have substantial efficiency in eliminating resistance and surges of bacteria. Nanomaterials with characteristics such as surface plasmonic resonance, photocatalysis, structural complexities, and optical features have been utilized to control metal ion release, generate reactive oxygen species, and produce heat for antibacterial applications. The superior characteristics of nanomaterials present an opportunity to explore and enhance their antibacterial activities leading to clinical applications. In this review, we comprehensively list three different antibacterial mechanisms of metal ion release, photodynamic therapy, and photothermal therapy based on nanomaterials. These three different antibacterial mechanisms are divided into their respective subgroups in accordance with recent achievements, showcasing prospective challenges and opportunities in clinical, environmental, and related fields.

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Section: Photothermal Therapymentioning

confidence: 99%

Emerging Trends in Nanomaterials for Antibacterial Applications

Yougbaré¹,

Mutalik²,

Okoro³

et al. 2021

IJN

127

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“…These liposomes become permeable at a temperature of ∼50 °C, as previously shown. 17 To check the photothermal effect of IR 780, two different ratios of lipid/IR 780 (100:1 and 100:5 weight ratio) were prepared using a similar lipid film-based method. The resultant product, liposome-IR 780 (LI), was stored at 4 °C until further use.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…The stability studies were carried out by following the protocol in our previously reported study. 17 Briefly, GM and [(GM@ Dox) LI]-PF solution were stored at 37 °C in cell culture media for 5 days. The nano-assemblies were monitored daily, and their stability was characterized by UV absorbance to track the longitudinal surface plasmon resonance (LSPR) intensity, aggregation index (AI), and zeta potential to monitor the change in surface charge.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…In our previous work, it has been shown that this nano-assembly introduced targeted antibiotic delivery against bacterial infection. 17 This work extends our previous work by utilizing the same nano-assembly, which has been optimized for anticancer drug delivery and contains an engineered core− shell particle, consisting of a drug-entrapped photosensitive core and a stimuli-responsive shell. 18 Gold nanorods (GNRs) were coated with mesoporous silica shells (GM) that enhance drug loading capability.…”

Section: ■ Introductionmentioning

confidence: 99%

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Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Patel

Rathnayake

Singh

et al. 2023

ACS Appl. Bio Mater.

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The delivery and accumulation of therapeutic drugs into cancer cells without affecting healthy cells are a major challenge for antitumor therapy. Here, we report the synthesis of a liposomal hybrid gold nano-assembly with enhanced photothermal activity for lung cancer treatment. The core components of the nano-assembly include gold nanorods coated with a mesoporous silica shell that offers an excellent drug-loading surface for encapsulation of doxorubicin. To enhance the photothermal capacity of nano-assembly, IR 780 dye was loaded inside a thermo-sensitive liposome, and then, the core nano-assembly was wrapped within the liposome, and GE-11 peptide and folic acid were conjugated onto the surface of the liposome to give the final nano-assembly [(GM@Dox) LI]-PF. The dual targeting approach of [(GM@Dox) LI]-PF leads to enhanced cellular uptake and improves the accumulation of nano-assemblies in cancer cells that overexpress the epidermal growth factor receptor and folate. The exposure of near-infrared laser irradiation can trigger photothermal-induced structural disruption of the nano-assembly, which allows for the precise and controllable release of Dox at targeted sites. Additionally, chemo-photothermal therapy was shown to be 11 times more effective in cancer cell treatment when compared to Dox alone. Our systematic study suggests that the nano-assemblies facilitate the cancer cells undergoing apoptosis via an intrinsic mitochondrial pathway that can be directly triggered by the chemo-photothermal treatment. This study offers an appealing candidate that holds great promise for synergistic cancer treatment.

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“…The experimental procedure of SAB formation was analyzed and systematically adapted for this purpose. [45][46][47] Correspondingly, the activation of carboxylate (R-COOH) presented on Ia, Ib and Ic (I series) to be covalently bound with primary amine (R-NH 2 ) was performed with application of amide coupling agents soluble in aqueous medium described in Section 4. [48][49][50][51] As a result, the dispersion of core-shell NMs was carried out as an eco-friendly process with different concentrations, which were determined experimen-tally by consecutive examination of SAB formation on Fourier transform IR (FT-IR).…”

Section: Functionalization Of Nps and Nrs And Respective Linking-reac...mentioning

confidence: 99%

A universal concept for area‐selective assembly of metal oxide core‐shell nanoparticles, nanorods, and organic molecules via amide coupling reactions

et al. 2022

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The deposition of nanomaterials (NMs) on substrate is a pertinent for a variety of applications in nanometer-sized electronics, mechanics, or catalysis. This paper establishes a universal and simple approach for assembly of functionalized metal oxide core nanoparticles (NPs) and nanorods (NRs) on a substrate with uniformity, area-selectivity, and full order control. Particularly, the aluminium oxide (AlO x ) NPs, titanium dioxide (TiO 2 ) NRs, and TiO 2 NPs functionalized by selfassembled monolayer (SAM) molecules are deposited on substrate alternatively layer-by-layer. This assembling is performed in solution on the pre-patterned surface with SAM molecules via amide coupling reactions in order to achieve the reaction-orthogonality. Moreover, this stacking of inorganic NPs/NRs in a terminated implementation is progressed into latter layer of TiO 2 NPs functionalized by 1-aminopyrene molecules representing an example of hybrid organicinorganic formation with fluorescence emission. The deposited layers are characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and total internal reflection fluorescence microscope (TIRFM). The significant versatility of stacked metal oxide core-shell NPs/NRs via based-solution method represents excellent and efficient applicability in manufacture of hybrid organicinorganic nanostructure.

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Near‐infrared responsive targeted drug delivery system that offer chemo‐photothermal therapy against bacterial infection

Cited by 15 publications

References 52 publications

Emerging Trends in Nanomaterials for Antibacterial Applications

Emerging Trends in Nanomaterials for Antibacterial Applications

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

A universal concept for area‐selective assembly of metal oxide core‐shell nanoparticles, nanorods, and organic molecules via amide coupling reactions

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