Near-Infrared Spatially Resolved Spectroscopy for Tablet Quality Determination

Igne, Benoît; Talwar, Sameer; Feng, Hanzhou; Drennen, James K.; Anderson, Carl A.

doi:10.1002/jps.24618

Cited by 20 publications

(12 citation statements)

References 37 publications

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“…Spectra collected by the channels located in close proximity to the light source exhibit strong scattering phenomena, whereas absorption is stronger as light travels deeper into the sample. Numerous spectra are collected in the course of one single measurement, with the same probe representing different degrees of light absorption and scattering [46].…”

Section: Basic Concept and Instrumentationmentioning

confidence: 99%

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Stranzinger

Markl

Khinast

et al. 2021

TrAC Trends in Analytical Chemistry

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Section: Basic Concept and Instrumentationmentioning

confidence: 99%

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Stranzinger

Markl

Khinast

et al. 2021

TrAC Trends in Analytical Chemistry

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“…In another study, the authors developed NIRS-based Chemometric models to successfully predict the influence of storage conditions on the phase transition of theophylline anhydrate tablets, and resulting changes in the tablet properties such as breaking force and dissolution (Otsuka et al, 2015 (Dave et al, 2015). Igne et al compared the usefulness of traditional single-point NIRS and spatially resolved spectroscopy (SRS) for assessing the homogeneity of tablet composition, and detection of tablet defects (Igne et al, 2015). In addition to traditional single-point NIRS, several published reports mention NIR chemical imaging as a highly useful, non-invasive technique for the analysis of tablet physical-mechanical properties.…”

Section: Figure1: Basic Configuration Of a Nir Spectrometermentioning

confidence: 99%

Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

Dave

Shahin

Youngren-Ortiz³

et al. 2017

International Journal of Pharmaceutics

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The density, porosity, breaking force, viscoelastic properties, and the presence or absence of any structural defects or irregularities are important physical-mechanical quality attributes of popular solid dosage forms like tablets. The irregularities associated with these attributes may influence the drug product functionality. Thus, an accurate and efficient characterization of these properties is critical for successful development and manufacturing of a robust tablets. These properties are mainly analyzed and monitored with traditional pharmacopeial and non-pharmacopeial methods. Such methods are associated with several challenges such as lack of spatial resolution, efficiency, or sample-sparing attributes. Recent advances in technology, design, instrumentation, and software have led to the emergence of newer techniques for non-invasive characterization of physical-mechanical properties of tablets. These techniques include near infrared spectroscopy, Raman spectroscopy, X-ray microtomography, nuclear magnetic resonance (NMR) imaging, terahertz pulsed imaging, laser-induced breakdown spectroscopy, and various acoustic- and thermal-based techniques. Such state-of-the-art techniques are currently applied at various stages of development and manufacturing of tablets at industrial scale. Each technique has specific advantages or challenges with respect to operational efficiency and cost, compared to traditional analytical methods. Currently, most of these techniques are used as secondary analytical tools to support the traditional methods in characterizing or monitoring tablet quality attributes. Therefore, further development in the instrumentation and software, and studies on the applications are necessary for their adoption in routine analysis and monitoring of tablet physical-mechanical properties.

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“…In SRS, data are collected at different angles from the excitation light source in order to collect both the transmitted and diffused light. SRS has been successfully used in food, 23 pharmaceutics, 24 and chemical applications, such as silica precipitation. 25 Emulsion polymerization consists of a heterogeneous medium that generates strong light diffusion related to particles, for which the SRS is well adapted.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of polymer content in an emulsion polymerization using spatially resolved spectroscopy in the near infrared region and Raman spectroscopy

Gheghiani

Caillol²,

Henrot³

et al. 2020

Polymer Engineering & Sci

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The potential of spatially resolved spectroscopy (SRS) for in situ monitoring is evaluated in this work. SRS is based on near‐infrared spectroscopy. It is well adapted to heterogeneous systems and collects information about both physical and chemical properties. In this work, the polymer content in emulsion copolymerization is predicted using SRS. The reaction was first carried out in batch mode for particle nucleation followed by semi‐continuous monomer addition under starved conditions to allow particle growth. SRS and Raman spectroscopy are compared, and the advantages and disadvantages of both methods are highlighted, revealing that each method has its own benefits. Different operating conditions were varied, including the monomer ratio, the surfactant mass fraction, and the agitation speed. Regression models were developed using partial least square for both techniques.

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Near-Infrared Spatially Resolved Spectroscopy for Tablet Quality Determination

Cited by 20 publications

References 37 publications

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

Monitoring of polymer content in an emulsion polymerization using spatially resolved spectroscopy in the near infrared region and Raman spectroscopy

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