Near-infrared spectra absorbance of blood from sickle cell patients and normal individuals

Nahavandi, Masoud; Nichols, James; Mohabatkar, Hassan; Gandjbakhche, Amir; Kato, Gregory J.

doi:10.1179/102453309x385133

Cited by 32 publications

(23 citation statements)

References 13 publications

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“…Briefly, NIRS principle is based on the relative transparency of tissue to light in the near-infrared region between 700 nm and 1000 nm, and on the oxygen-dependent absorption changes of hemoglobin. NIRS can be used in sickle cell patients since the near-infrared spectra absorbance of hemoglobin S is similar to the one of normal hemoglobin [18].…”

Section: Methodsmentioning

confidence: 99%

Normal Muscle Oxygen Consumption and Fatigability in Sickle Cell Patients Despite Reduced Microvascular Oxygenation and Hemorheological Abnormalities

et al. 2012

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Background/AimAlthough it has been hypothesized that muscle metabolism and fatigability could be impaired in sickle cell patients, no study has addressed this issue.MethodsWe compared muscle metabolism and function (muscle microvascular oxygenation, microvascular blood flow, muscle oxygen consumption and muscle microvascular oxygenation variability, which reflects vasomotion activity, maximal muscle force and local muscle fatigability) and the hemorheological profile at rest between 16 healthy subjects (AA), 20 sickle cell-hemoglobin C disease (SC) patients and 16 sickle cell anemia (SS) patients.ResultsMuscle microvascular oxygenation was reduced in SS patients compared to the SC and AA groups and this reduction was not related to hemorhelogical abnormalities. No difference was observed between the three groups for oxygen consumption and vasomotion activity. Muscle microvascular blood flow was higher in SS patients compared to the AA group, and tended to be higher compared to the SC group. Multivariate analysis revealed that muscle oxygen consumption was independently associated with muscle microvascular blood flow in the two sickle cell groups (SC and SS). Finally, despite reduced muscle force in sickle cell patients, their local muscle fatigability was similar to that of the healthy subjects.ConclusionsSickle cell patients have normal resting muscle oxygen consumption and fatigability despite hemorheological alterations and, for SS patients only, reduced muscle microvascular oxygenation and increased microvascular blood flow. Two alternative mechanisms can be proposed for SS patients: 1) the increased muscle microvascular blood flow is a way to compensate for the lower muscle microvascular oxygenation to maintain muscle oxygen consumption to normal values or 2) the reduced microvascular oxygenation coupled with a normal resting muscle oxygen consumption could indicate that there is slight hypoxia within the muscle which is not sufficient to limit mitochondrial respiration but increases muscle microvascular blood flow.

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Section: Methodsmentioning

confidence: 99%

Normal Muscle Oxygen Consumption and Fatigability in Sickle Cell Patients Despite Reduced Microvascular Oxygenation and Hemorheological Abnormalities

et al. 2012

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“…As most SCD patients are not constantly hypoxemic, the blood hypoxemia and the tissue hypoxia they experience are presumably of intermittent nature, a phenomenon that has been well documented in murine models of SCD [20]. However, as evidenced from near-infrared spectroscopy studies assessing cerebral hypoxia in SCD [21], hypoxia may be present at all times in some tissues. Consequently, the unstable nature of the magnitude of the tissue hypoxemia may be a frequent phenomenon in SCD, even when pulse oximetry appears to be in the normal range [16,22,23].…”

Section: Nocturnal Hypoxemiamentioning

confidence: 99%

Hemoglobinopathies and sleep – The road less traveled

Gileles‐Hillel

Kheirandish‐Gozal

Gozal

2015

Sleep Medicine Reviews

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Section: Near-infrared Spectroscopy (Nirs) and Determination Of The Mmentioning

confidence: 99%

Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle?

Waltz

Hardy‐Dessources

Lemonne

et al. 2015

Clinical Hemorheology and Microcirculation

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The hematocrit-to-viscosity ratio (HVR) has been widely used has an estimate of red blood cell (RBC) oxygen transport effectiveness into the microvasculature or as an oxygen delivery index. However, no study investigated the possibility of HVR to truly reflect RBC oxygen transport effectiveness or to be an oxygen delivery index. We measured blood viscosity at high shear rate (225 s −1 ), hematocrit, HVR, as well as the microvascular oxyhemoglobin saturation (TOI; tissue oxygen index) by spatial resolved near-infrared spectroscopy (NIRS) at cerebral and muscle levels in three population known to have various degrees of hemorheological abnormalities: healthy subjects (AA), patients with sickle cell SC disease (SC) characterized by moderate anemia and patients with sickle cell anemia (SS) marked by severe anemia. At both the cerebral and muscle level, HVR was positively correlated with TOI (r = 0.28; p = 0.03 and r = 0.38; p = 0.003, at the cerebral and muscle level, respectively). These findings suggest that HVR probably play a key role in blood flow and hemodynamic regulation in the microvasculature, hence modulating the amount of oxygen available for tissues. Nevertheless, the strengths of the associations are weak (R 2 < 0.50), suggesting that other determinants modulate microvascular blood flow and oxygenation, such as vascular geometry and vasomotor reserve.

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Near-infrared spectra absorbance of blood from sickle cell patients and normal individuals

Cited by 32 publications

References 13 publications

Normal Muscle Oxygen Consumption and Fatigability in Sickle Cell Patients Despite Reduced Microvascular Oxygenation and Hemorheological Abnormalities

Normal Muscle Oxygen Consumption and Fatigability in Sickle Cell Patients Despite Reduced Microvascular Oxygenation and Hemorheological Abnormalities

Hemoglobinopathies and sleep – The road less traveled

Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle?

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