Near-infrared spectral methods for noninvasively measuring blood glucose

Sun, Fei; Kong, Deyi; Mei, Tao; Tao, Yongchun

doi:10.1117/12.521999

Cited by 8 publications

(2 citation statements)

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“…Measurements from the blood became a bigger problem in children with diabetes. Thus, more modern measurement methods have become necessary for diabetic patients, enabling comfortable and frequent tests (Fei et al, 2004;Formosa, 2013). In light of the same idea, optical systems that work without taking blood samples from the patient have begun to be studied.…”

Section: Introductionmentioning

confidence: 99%

Comparing the light response of D-glucose in polyacrylamide hydrogel and water in NIR spectral region by using an LED based portable device

et al. 2022

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The spectral properties of the molecules depend on the matrix in which it is present. The interaction of the molecule with the solute molecules affects the vibrational and rotational modes of the molecule. In this study, an absorption-based system was designed to show how the absorbance properties of glucose change in polyacrylamide hydrogel, and the measurements were performed at different wavelengths; 960 nm, 1450 nm, 1550 nm, and 1950 nm. It was observed that the system is sensitive to glucose at 1450 nm and 1950 nm wavelengths in polyacrylamide hydrogel, whereas it is only sensitive at 1450 nm in water which is due to the high absorbance of water at 1950 nm. In polyacrylamide hydrogel, water molecules mostly gather around the polymer chains via electrostatic interactions and the absorbance of water decreases which results in an increasing absorbance of glucose. According to the results, the responsivity of the system at 960 nm and 1550 nm, which are the wavelengths commonly used LED-based systems for measuring glucose in literature, is not high enough for reliable glucose measurements when compared with 1450 nm and 1950 nm.

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Section: Introductionmentioning

confidence: 99%

Comparing the light response of D-glucose in polyacrylamide hydrogel and water in NIR spectral region by using an LED based portable device

et al. 2022

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“…4 Many methods have been used for noninvasve glucose measurement, including Raman Spectroscopy, 5 Midinfrared Spectroscopy, 6 Near Infrared Spectroscopy. 7 In this study, we use Near Infrared Spectroscopy(NIRS) due to its relatively higher penetration depth and the weaker water absorption in this spectral area. The literature on measuring blood glucose using NIRS is rich, but the results of these studies are usually not conclusive.…”

Section: Introductionmentioning

confidence: 99%

On feasibility of near-infrared spectroscopy for noninvasive blood glucose measurements

Vural

Yoleri

Torun

2019

Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics

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Non-invasive blood glucose measurement has long been desired since the invasive methods are not suitable to perform continuous monitoring. Near Infrared Spectroscopy is one of the most popular methods used in studies; however, despite more than 20 years of research, a practical and reliable noninvasive NIR glucose sensor is yet to be developed. In this study, we investigated the feasibility of NIRS towards the detection of glucose concentration. Although we can obtain adequate sensitivity, our measurements suffer from poor selectivity due to the fact that we can only detect the impurity level of water by NIRS due to strong water absorbance.

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Double beam near-infrared spectrometer for compensation of background water absorption and instrumental drift in intensity

Chang

Peng

2007

Optoelectron. Lett.

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A double beam near-infrared spectrometer is developed to compensate the water absorption and instrumental drift in intensity. The spectrometer may be used for both single and double beam measurements, and the two operation modes are compared. The results show that the double beam technique eliminates instrumental drift in the single beam measurement and therefore the stability of the system increases by more than 20%. The compensation of the double beam system on water absorption is verified by the measurement of fat content in milk. The results show that the spectrum data based on double beam mode get better calibration model and lower prediction error than traditional single beam mode. CLC numbers: TH744.1; TN219; O433.1 Document code: A Article ID: 1673-1905(2007)03-0211-04 DOI Near-infrared (NIR) spectroscopy is a rapid, reagent-less, and non-destructive analytical technique, which is being increasingly employed in chemistry, pharmaceutics industry and food engineering. Recently, the efforts have turned to biomedical applications, such as detection in the level of glucose in blood [1][2][3] , determination of blood parameter [4][5] , concentration monitoring hemoglobin, oxyhemoglobin and deoxyhemoglobin in human tissue [6][7] . With its unique superiority, NIR spectroscopy is an attractive alternative to traditional chemical assays and is lowly developing into a viable technology.The key of NIR spectroscopy technique used for quantification is that it can detect and predict concentrations with acceptable repeatability and precision. To achieve this goal, NIR spectral instrumental drift and intrinsic strong background absorption have to be overcome. Most conventional NIR spectrometers are single beam (SB) modes and require periodic measurements of reference (background) spectra to remove the variations caused by changing background absorption and instrument conditions. This approach is only if the reference is constant and the intensity of instruments does not drift during the measurements of the reference and the sample. Under some conditions, however, the temporal difference of the two measurements may be effective on the test results because the instrumental drift in intensity may be comparable to the signals from the components of interest.Therefore we have developed a double beam (DB) spectrometer for constituent concentration measurements. For NIR spectra of aqueous based biological samples, water is always a critical matrix component. We firstly concentrate on the compensation of background water absorption. The purpose is to improve measurement accuracy by using the double beam technique.A major problem in the design of DB system is the choice of reference, which is based on the composition and absorbance characteristics of the analyte. Water is a strong absorber in NIR spectral region, the spectrum of aqueous stuff usually shows similar characters to the one of water, and the intensity of transmitted light through water is in the same range as for aqueous stuff. Therefore, if the reference is measured...

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Near-infrared spectral methods for noninvasively measuring blood glucose

Cited by 8 publications

References 0 publications

Comparing the light response of D-glucose in polyacrylamide hydrogel and water in NIR spectral region by using an LED based portable device

Comparing the light response of D-glucose in polyacrylamide hydrogel and water in NIR spectral region by using an LED based portable device

On feasibility of near-infrared spectroscopy for noninvasive blood glucose measurements

Double beam near-infrared spectrometer for compensation of background water absorption and instrumental drift in intensity

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