Near-infrared spectroscopy analysis of frontal lobe dysfunction in schizophrenia

Shinba, Toshikazu; Nagano, Mitsuru; Kariya, Nobutoshi; Ogawa, K.; Shinozaki, Takiko; Shimosato, Seiji; Hoshi, Yoko

doi:10.1016/s0006-3223(03)00547-x

Cited by 77 publications

(49 citation statements)

References 56 publications

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“…Some factors that might influence RNG in patients with SLE and schizophrenia are medications of corticosteroids, and psychotropic agents, ageing, and sex difference. Concerning corticosteroids, we could not find any reports assessing influence on RNG, although two animal studies suggested that exogenous administration of corticosteroids could influence prefrontal cortex (PFC) function (21,22), whereas psychotropic agents were unlikely to influence the frontal lobe dysfunction in schizophrenia (23). We could find no studies on the influence of ageing on RNG; however, there were no difference in ages between patients with SLE and schizophrenia in the current study.…”

Section: Discussioncontrasting

confidence: 65%

Random number generation evaluation in patients with systemic lupus erythematosus indicates a heterogeneous nature of central nervous system vulnerability

Matsukawa

Nagashima

Kamei³

et al. 2006

Scandinavian Journal of Rheumatology

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CNS vulnerability may be prolonged in patients who have a history of NP lupus even when they appear to be in normal NP status. The damage in random number generation (RNG) observed in patients with a history of NP lupus seemed equal to that found in those with schizophrenia, whereas those patients never having NP lupus appeared to be equal to the controls. The current study suggests a heterogeneous nature of SLE and prolonged damage, especially in CNS vulnerability, when evaluating with RNG.

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Section: Discussioncontrasting

confidence: 65%

Random number generation evaluation in patients with systemic lupus erythematosus indicates a heterogeneous nature of central nervous system vulnerability

Matsukawa

Nagashima

Kamei³

et al. 2006

Scandinavian Journal of Rheumatology

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“…As demonstrated in our previous studies, fNIRS offers robust advantages such as its compactness (useful in confined experimental settings), affordable price, tolerance to body motion and accessibility (Ehlis et al, 2014; Herrmann et al, 2004; Herrmann et al, 2005; Hock et al, 1997; Matsuo et al, 2000; Matsuo et al, 2003; Miyai et al, 2001; Moriai-Izawa et al, 2012; Okamoto et al, 2004b; Okamoto et al, 2006; Shinba et al, 2004; Strangman et al, 2002a; Suto et al, 2004), which, in addition, have allowed it to be applied to the clinical assessment of ADHD children (Monden et al, 2012a; Monden et al, 2012b; Nagashima et al, 2014). …”

Section: Introductionmentioning

confidence: 92%

Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: A fNIRS study

Nagashima¹,

Monden²,

Dan

et al. 2014

NeuroImage: Clinical

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The object of the current study is to explore the neural substrate for effects of atomoxetine (ATX) on inhibitory control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS). We monitored the oxy-hemoglobin signal changes of sixteen ADHD children (6–14 years old) performing a go/no-go task before and 1.5 h after ATX or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Sixteen age- and gender-matched normal controls without ATX administration were also monitored. In the control subjects, the go/no-go task recruited the right inferior and middle prefrontal gyri (IFG/MFG), and this activation was absent in pre-medicated ADHD children. The reduction of right IFG/MFG activation was acutely normalized after ATX administration but not placebo administration in ADHD children. These results are reminiscent of the neuropharmacological effects of methylphenidate to up-regulate reduced right IFG/MFG function in ADHD children during inhibitory tasks. As with methylphenidate, activation in the IFG/MFG could serve as an objective neuro-functional biomarker to indicate the effects of ATX on inhibitory control in ADHD children. This promising technique will enhance early clinical diagnosis and treatment of ADHD in children, especially in those with a hyperactivity/impulsivity phenotype.

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“…NIRS is therefore useful in assessing the brain function of healthy adults (16) and patients with psychiatric disorders, and has been used in several neuroimaging studies of schizophrenia patients (16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Multi-channel near-infrared spectroscopy reveals reduced prefrontal activation in schizophrenia patients during performance of the kana Stroop task

et al. 2012

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: The purpose of the present study was to investigate the activity of frontal lobe of patients with schizophrenia during performance of two Japanese versions of the Stroop task (kana and kanji) by measuring changes in the concentration of oxygenated hemoglobin (oxyHb) with near-infrared spectroscopy (NIRS). Fourteen schizophrenia patients and 14 age-and gender-matched healthy control subjects participated in the study after giving consent. The relative changes of concentrations of oxyHb were measured by NIRS during performance of the Stroop task. Significant Stroop effects, as measured by the number of correct responses, were observed with both the kana and the kanji versions. Analysis of NIRS data revealed that the schizophrenia patients showed reduced activation in the prefrontal cortex compared to healthy controls during performance of the kana Stroop task, and that both schizophrenia patients and healthy controls showed lack of activity in the prefrontal cortex during performance of the kanji Stroop task. The results of the present study suggest the possibility that the kana Stroop task cause a greater Stroop effect than the kanji Stroop task, and schizophrenia patients show decreased prefrontal vascular reactivity associated with the inhibition required during the performance of the kana Stroop task. J. Med. Invest. 59 : 45-52, February, 2012

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Near-infrared spectroscopy analysis of frontal lobe dysfunction in schizophrenia

Cited by 77 publications

References 56 publications

Random number generation evaluation in patients with systemic lupus erythematosus indicates a heterogeneous nature of central nervous system vulnerability

Random number generation evaluation in patients with systemic lupus erythematosus indicates a heterogeneous nature of central nervous system vulnerability

Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: A fNIRS study

Multi-channel near-infrared spectroscopy reveals reduced prefrontal activation in schizophrenia patients during performance of the kana Stroop task

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