Near‐infrared spectroscopy as a potential non‐invasive tool in the assessment of disease activity in vitiligo patients

Bruyne, Sander De; Speeckaert, Reinhart; Himpe, Jonas; Delanghe, Joris

doi:10.1111/exd.14097

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…There are major differences between the stable and active stages of vitiligo, and the treatment plan for each stage also has its own characteristics. 6 However, the observation indexes (larger white area, lighter color, and Koebner phenomenon) lag behind the clinical severity of the disease, and there is no predictive index. Therefore, identification of internal markers would help to diagnose the active stage of vitiligo as soon as possible.…”

Section: Introductionmentioning

confidence: 99%

Increased expression of serum MCP-1, CCL3, IL-6, and IL-17 in patients with vitiligo and IL-17 as a potential clinical marker for active vitiligo

Zhao

Zhang

et al. 2022

International Journal of Dermatology and Venereology

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Objective: Vitiligo is a chronic, acquired depigmentation of the skin, which can be divided into active and stable vitiligo. The stable and active stages are not immutable and often alternate. Identification of internal markers would help to diagnose the active stage of vitiligo, and the purpose of this study was to find potential active markers in the progression of vitiligo.Methods: We compared 30 healthy controls to 60 patients with vitiligo (30 with active disease and 30 with stable disease) regarding the expression of serum monocyte chemoattractant protein (MCP)-1, chemokine (C-C motif) ligand (CCL) 3, CCL5, CCL21, interleukin (IL)-6, and IL-17. Specimens were collected from May 2017 to December 2018. Serological detection was carried out by enzyme-linked immunosorbent assay. The difference between groups was compared by Kruskal-Wallis H test and Mann-Whitney U test.Results: We found that the serum levels of MCP-1, CCL3, IL-6, and IL-17 were significantly higher in patients with vitiligo than in healthy controls (P < 0.01 ) and that IL-17 was higher in patients with active vitiligo than in those with stable vitiligo (P < 0.01). After 3months of treatment, the serum IL-17 level of patients with active vitiligo was not significantly different from that before treatment (P = 0.526); after 6months of treatment, however, the serum IL-17 level had significantly decreased (P < 0.01). Conclusion:These findings suggest that the serum IL-17 level can be used as a marker of vitiligo disease activity giving it certain guiding significance for clinical treatment.

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Section: Introductionmentioning

confidence: 99%

Increased expression of serum MCP-1, CCL3, IL-6, and IL-17 in patients with vitiligo and IL-17 as a potential clinical marker for active vitiligo

Zhao

Zhang

et al. 2022

International Journal of Dermatology and Venereology

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Comment on “Diagnosis of HCV infection using attenuated total reflection-FTIR spectra of Freeze-Dried sera”

Bruyne

2022

Infrared Physics & Technology

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Non-invasive skin measurement methods and diagnostics for vitiligo: a systematic review

Abdi¹,

Anthony²,

Farkouh³

et al. 2023

Front. Med.

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Vitiligo is a multifaceted autoimmune depigmenting disorder affecting around 0.5 to 2.0% of individuals globally. Standardizing diagnosis and therapy tracking can be arduous, as numerous clinical evaluation methods are subject to interobserver variability and may not be validated. Therefore, there is a need for diagnostic tools that are objective, dependable, and preferably non-invasive.AimsThis systematic review provides a comprehensive overview of the non-invasive objective skin measurement methods that are currently used to evaluate the diagnosis, severity, and progression of vitiligo, as well as the advantages and limitations of each technique.MethodsThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist was used for the systematic review. Scopus, Embase, Cochrane Library, and Web of Science databases were comprehensively searched for non-invasive imaging and biophysical skin measuring methods to diagnose, evaluate the severity of, or monitor the effects of vitiligo treatment. The risk of bias in included articles was assessed using the QUADAS-2 quality assessment scale.ResultsAn extensive literature search resulted in 64 studies for analysis, describing eight imaging techniques (reflectance confocal microscopy, computer-aided imaging analysis, optical coherence tomography, infrared photography, third-harmonic generation microscopy, multiphoton microscopy, ultraviolet light photography, and visible light/digital photograph), and three biophysical approaches (dermoscopy, colorimetry, spectrometry) used in diagnosing and assessing vitiligo. Pertinent information about functionality, mechanisms of action, sensitivity, and specificity was obtained for all studies, and insights into the strengths and limitations of each diagnostic technique were addressed. Methodological study quality was adequate; however, statistical analysis was not achievable because of the variety of methods evaluated and the non-standardized reporting of diagnostic accuracy results.ConclusionsThe results of this systematic review can enhance clinical practice and research by providing a comprehensive overview of the spectrum of non-invasive imaging and biophysical techniques in vitiligo assessment. Studies with larger sample sizes and sound methodology are required to develop verified methods for use in future practice and research.Systematic review registration(PROSPERO) database, (CRD42023395996).

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Near‐infrared spectroscopy as a potential non‐invasive tool in the assessment of disease activity in vitiligo patients

Cited by 3 publications

References 24 publications

Increased expression of serum MCP-1, CCL3, IL-6, and IL-17 in patients with vitiligo and IL-17 as a potential clinical marker for active vitiligo

Increased expression of serum MCP-1, CCL3, IL-6, and IL-17 in patients with vitiligo and IL-17 as a potential clinical marker for active vitiligo

Comment on “Diagnosis of HCV infection using attenuated total reflection-FTIR spectra of Freeze-Dried sera”

Non-invasive skin measurement methods and diagnostics for vitiligo: a systematic review

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