Near-Infrared Spectroscopy Assessment of Cerebral Oxygen Metabolism in the Developing Premature Brain

Roche-Labarbe, Nadège; Fenoglio, Angela; Aggarwal, Alpna; Dehaes, Mathieu; Carp, Stefan A.; Franceschini, Maria Angela; Grant, P. Ellen

doi:10.1038/jcbfm.2011.145

Cited by 93 publications

(84 citation statements)

References 43 publications

(78 reference statements)

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“…In addition, good agreement was also found between the absolute blood flow index determined from ML DCS ( Table 2) and our previous values derived from autocorrelation functions measured directly on the brain, (~48x10 −9 cm 2 /s at normocapnia and ~28x10 −9 cm 2 /s at hypocapnia) [30]. This agreement suggests that F B could be used as a marker to track longitudinal changes in CBF, similar to previous DCS studies involving infants [41]. However, this would require careful assessment of the reproducibility of F B considering the added complexity of the analysis.…”

Section: Discussionsupporting

confidence: 71%

Assessment of a multi-layered diffuse correlation spectroscopy method for monitoring cerebral blood flow in adults

Verdecchia

Diop

Lee

et al. 2016

Biomed. Opt. Express

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Diffuse correlation spectroscopy (DCS) is a promising technique for brain monitoring as it can provide a continuous signal that is directly related to cerebral blood flow (CBF); however, signal contamination from extracerebral tissue can cause flow underestimations. The goal of this study was to investigate whether a multi-layered (ML) model that accounts for light propagation through the different tissue layers could successfully separate scalp and brain flow when applied to DCS data acquired at multiple source-detector distances. The method was first validated with phantom experiments. Next, experiments were conducted in a pig model of the adult head with a mean extracerebral tissue thickness of 9.8 ± 0.4 mm. Reductions in CBF were measured by ML DCS and computed tomography perfusion for validation; excellent agreement was observed by a mean difference of 1.2 ± 4.6% (CI 95% : −31.1 and 28.6) between the two modalities, which was not significantly different.

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Section: Discussionsupporting

confidence: 71%

Assessment of a multi-layered diffuse correlation spectroscopy method for monitoring cerebral blood flow in adults

Verdecchia

Diop

Lee

et al. 2016

Biomed. Opt. Express

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“…Although beyond the scope of this study, other reasons for differences between rScO 2 values measured in extremely preterm infants can be manifold. Besides differences in the techniques as stated above, differences in postmenstrual and postnatal age (25)(26)(27)(28) or differences induced by the different locations of the brain under investigation (29) may contribute to differences in rScO 2 . It will be worthwhile and clinically very important to further investigate these issues in relation to cerebral oxygen saturation.…”

Section: Comparing Nirs Devices and Sensorsmentioning

confidence: 99%

Comparing near-infrared spectroscopy devices and their sensors for monitoring regional cerebral oxygen saturation in the neonate

et al. 2013

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Background: Near-infrared spectroscopy (NIRS) is an upcoming clinical method for monitoring regional cerebral oxygen saturation (rScO 2 ) in neonates. There is a growing market offering different devices and sensors. Even though this technique is increasingly clinically applied, little is known about the similarities and/or differences in rScO 2 values between the different devices and sensors. The aim of this study was to compare the rScO 2 values obtained in (preterm) neonates with all available sensors of three frequently used NIRS devices. Methods: Fifty-five neonates admitted to our neonatal intensive care unit (NICU) were included in this study. rScO 2 was simultaneously monitored bilaterally with two different NIRS sensors (left and right frontoparietal) for at least 1 h. Then, the sensors were switched, and measurements were collected for at least another hour. results: We detected a rather close correlation between all investigated sensors from the three different NIRS devices, but absolute rScO 2 values showed substantial differences: BlandAltman analysis showed average differences from 10 to 15%. conclusion: Although the rScO 2 values correlated well between different NIRS sensors, sometimes there were substantial differences between the absolute rScO 2 values, which may complicate clinical application.

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“…The general clinical characteristics of the subjects are listed in Table 1. The clinical summary for preterm infants is described in Roche-Labarbe et al (2011) (infant 43 is excluded in this study because of bilateral germinal matrix and grade II intraventricular hemorrhage, and infant 42 because of 5-min Apgar of 5 due to lung prematurity). Infants were measured every 1--2 weeks during their hospital stay for a total of 244 measurements.…”

Section: Subjectsmentioning

confidence: 99%

Regional and Hemispheric Asymmetries of Cerebral Hemodynamic and Oxygen Metabolism in Newborns

Lin

Dehaes

Roche-Labarbe

et al. 2012

Biomedical Optics and 3-D Imaging

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Understanding the evolution of regional and hemispheric asymmetries in the early stages of life is essential to the advancement of developmental neuroscience. By using 2 noninvasive optical methods, frequency-domain near-infrared spectroscopy and diffuse correlation spectroscopy, we measured cerebral hemoglobin oxygenation (SO 2 ), blood volume (CBV), an index of cerebral blood flow (CBF i ), and the metabolic rate of oxygen (CMRO 2i ) in the frontal, temporal, and parietal regions of 70 premature and term newborns. In concordance with results obtained using more invasive imaging modalities, we verified both hemodynamic (CBV, CBF i , and SO 2 ) and metabolic (CMRO 2i ) parameters were greater in the temporal and parietal regions than in the frontal region and that these differences increased with age. In addition, we found that most parameters were significantly greater in the right hemisphere than in the left. Finally, in comparing age-matched males and females, we found that males had higher CBF i in most cortical regions, higher CMRO 2i in the frontal region, and more prominent right--left CBF i asymmetry. These results reveal, for the first time, that we can detect regional and hemispheric asymmetries in newborns using noninvasive optical techniques. Such a bedside screening tool may facilitate early detection of abnormalities and delays in maturation of specific cortical areas.

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Near-Infrared Spectroscopy Assessment of Cerebral Oxygen Metabolism in the Developing Premature Brain

Cited by 93 publications

References 43 publications

Assessment of a multi-layered diffuse correlation spectroscopy method for monitoring cerebral blood flow in adults

Assessment of a multi-layered diffuse correlation spectroscopy method for monitoring cerebral blood flow in adults

Comparing near-infrared spectroscopy devices and their sensors for monitoring regional cerebral oxygen saturation in the neonate

Regional and Hemispheric Asymmetries of Cerebral Hemodynamic and Oxygen Metabolism in Newborns

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