Near-infrared spectroscopy can detect differences in vascular responsiveness to a hyperglycaemic challenge in individuals with obesity compared to normal-weight individuals

Soares, Rogério N.; Reimer, Raylene A.; Alenezi, Zaid; Doyle‐Baker, Patricia K.; Murias, Juan M.

doi:10.1177/1479164117731481

Cited by 18 publications

(30 citation statements)

References 41 publications

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“…Measurement of the sensitivity of STO 2 upslope has been well documented and supported in recent years, because NIRS is a low‐cost, easy‐to‐use methodology and has low test–retest variability both within and between days (McLay et al., ; Rosenberry et al., ; Soares et al., ). Soares et al () found that STO 2 upslope was positively correlated with %FMD of the brachial artery, a measure of cardiovascular health.…”

Section: Discussionmentioning

confidence: 99%

“…the STO 2 reperfusion rate [STO 2 upslope (as a percentage per minute)] during PORH}. Research supports that NIRS, as a measure for microvascular responsiveness, is repeatable between trials (McLay, Nederveen, Pogliaghi, Paterson, & Murias, ) and sensitive to factors such as training (Soares, George, Proctor, & Murias, ), occlusion duration (McLay, Gilbertson, Pogliaghi, Paterson, & Murias, ), obesity (Soares & Murias, ), glucose load (Soares, Reimer, Alenezi, Doyle‐Baker, & Murias, ) and age (Rosenberry et al., ). Such findings support that NIRS coupled with PORH is an effective way to measure vascular health and assess the degree of vascular impairment in certain disease states.…”

Section: Introductionmentioning

confidence: 96%

“…Thus, a potential ‘disease state’ that is a precursor for type 2 diabetes and CVD is undiagnosed. Excess blood glucose is known to impair vascular health and responsiveness (Soares et al., ), yet no research has been done to investigate how excess insulin in the blood, as occurs in early insulin resistance before dysglycaemia, might alter microvascular responsiveness. Understanding the relationship between varying levels of insulin sensitivity and vascular responsiveness is crucial to better screening for states before prediabetes/type 2 diabetes and early‐onset microvascular impairment.…”

Section: Introductionmentioning

confidence: 99%

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Reduced insulin sensitivity in young, normoglycaemic subjects alters microvascular tissue oxygenation during postocclusive reactive hyperaemia

Townsend

Deysher

Xie

et al. 2019

Experimental Physiology

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New Findings What is the central question of the study?Are measures of reduced insulin sensitivity in young, normoglycaemic subjects correlated with near‐infrared spectroscopy‐derived microvascular responsiveness [tissue oxygen saturation reperfusion rate (STO2 upslope)] during postocclusive reactive hyperaemia? What is the main finding and its importance?A sevenfold range of hepatic insulin sensitivity is significantly correlated (r = 0.44, P = 0.02) with STO2 upslope after transient tissue ischaemia. Near‐infrared spectroscopy may be an important tool for determining altered microvascular function before onset of hyperglycaemia. Identification of pre‐type 2 diabetes much earlier than with the present clinical criteria is important for pre‐emptive measures against microvascular deterioration. Abstract Near‐infrared spectroscopy (NIRS) measurement of postocclusive reactive hyperaemia (PORH) tissue oxygen saturation reperfusion rate [STO2 upslope (as a percentage per minute)] has recently been correlated with the percentage of flow‐mediated dilatation (%FMD). Cardiovascular disease is associated with impairments in %FMD. Reduced insulin sensitivity may negatively affect the vascular system for many years before prediabetes/type 2 diabetes states. The aim of this study was to determine whether static and dynamic STO2 parameters during PORH are correlated with reduced insulin sensitivity in young, normoglycaemic subjects. Glucose and insulin were measured during an oral glucose tolerance test in 18‐ to 26‐year‐old, healthy subjects (11 men and 11 women), and STO2 was measured during PORH of antebrachial muscle. Hepatic (ISIHOMA) and whole‐body (ISICOMP) insulin sensitivities were calculated. The STO2 upslope was negatively correlated with minimal STO2 (r = −0.5, P = 0.01). The change of STO2 from minimum to baseline (ΔSTO2) was significantly negatively correlated with fasting insulin (r = −0.5, P = 0.01) and a positively correlated with ISIHOMA (r = 0.65, P = 0.001). The minimum STO2 was significantly negatively correlated with ISIHOMA, and STO2 upslope was significantly positively correlated with ISIHOMA (r = 0.44, P = 0.02). The minimum STO2 (a measure of O2 extraction while the cuff was inflated), ΔSTO2 (a measure of the amount of reperfusion) and STO2 upslope (a measure of responsiveness of the microcirculation to ischaemia) were all positively correlated with ISIHOMA, one of the longest‐used measures of insulin sensitivity. The NIRS‐derived STO2 might be a useful tool for assessing how levels of reduced insulin sensitivity in young, normoglycaemic adults affect the microvasculature.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reduced insulin sensitivity in young, normoglycaemic subjects alters microvascular tissue oxygenation during postocclusive reactive hyperaemia

Townsend

Deysher

Xie

et al. 2019

Experimental Physiology

View full text Add to dashboard Cite

show abstract

“…,; Soares et al. ; Soares et al., ). By using the NIRS‐VOT technique, muscle oxygen saturation (StO 2 ) can be measured and microvascular responsiveness can be assessed by calculating the steepness and the area under the curve of the overshoot of the StO 2 signal during re‐oxygenation.…”

Section: Introductionmentioning

confidence: 98%

Effects of a rehabilitation program on microvascular function of CHD patients assessed by near‐infrared spectroscopy

Soares

Murias

Saccone³

et al. 2019

Physiol Rep

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This study aimed to evaluate whether near‐infrared spectroscopy ( NIRS )‐derived reperfusion slope would detect the effects of a 12‐week rehabilitation program on lower limb microvascular responsiveness in patients with coronary heart disease ( CHD ). Ten CHD patients (7 males and 3 females; 57.3 ± 7.6 years) underwent 12 weeks of drug treatment and high‐intensity interval training ( HIIT ), 2 times per week (40 min/session). Microvascular responsiveness was assessed by using NIRS assessment of muscle oxygen saturation (StO 2 ) combined with a vascular occlusion test ( VOT ) ( NIRS ‐ VOT ). NIRS ‐ VOT measures were taken at pre‐ and postintervention, and microvascular responsiveness was evaluated by examining the slope 2 of re‐oxygenation rate (slope 2 StO 2 ) and the area under the curve (StO 2 AUC ) of StO 2 signal following cuff release subsequent to a 5‐min occlusion period. The slope 2 StO 2 was significantly steeper after 12 weeks of training (4.8 ± 1.6% sec −1 ) compared to the pretraining (3.1 ± 1.6% sec −1 ) ( P < 0.05). The area under the curve for the change in the % StO 2 signal during re‐oxygenation increased significantly from 3494 ± 2372%∙sec at pretraining to 9006 ± 4311%∙sec at post‐training ( P < 0.05). NIRS ‐ VOT technique detected the improvements of 12 weeks of rehabilitation program in the lower limb microvascular responsiveness of CHD patients.

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“…Thus, properly assessing vascular function within conduit artery and the microvascular circulation is important for prevention, early detection, and monitoring of CVD . In relation to this, the use of near‐infrared spectroscopy (NIRS) combined with vascular occlusion test (VOT) technique (NIRS‐VOT) has been demonstrated to be a useful tool for assessment of microvascular function . This technique evaluates microvascular reactivity by assessing the steepness of the upslope of the muscle oxygen saturation signal (reperfusion slope, % per s), typically following a 5‐min period of limb occlusion .…”

Section: Introductionmentioning

confidence: 99%

The association between near‐infrared spectroscopy assessment of microvascular reactivity and flow‐mediated dilation is disrupted in individuals at high risk for cardiovascular disease

et al. 2019

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Objective This study aimed to evaluate the correlation between the NIRS‐derived reperfusion slope and %FMD in the arm of healthy and at high risk for CVD individuals. Methods Twelve healthy (24 ± 4 years) and twelve at high risk for cardiovascular disease (65 ± 11 years) individuals participated in the study. The individuals were submitted to a conduit artery FMD followed by a NIRS‐VOT microvascular function test in the arm. Microvascular responsiveness was calculated as the forearm reperfusion slope, and macrovascular function was assessed as the percent of change in FMD (%FMD) of the brachial artery. Results There was a significant correlation between reperfusion slope and %FMD (R = 0.61, P < 0.05) in the healthy group; however, no significant correlation between FMD and reperfusion slope (R = −0.21, P > 0.05) was found in individuals at high risk for CVD. Conclusion The correlation between NIRS‐derived reperfusion slope and %FMD was disrupted in the arm of individuals at high risk for cardiovascular disease compared to healthy individuals. The findings of the present study reinforce the importance of examining vascular function at microvasculature and conduit artery level, especially in populations with risk factors for CVD.

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Near-infrared spectroscopy can detect differences in vascular responsiveness to a hyperglycaemic challenge in individuals with obesity compared to normal-weight individuals

Abstract: Near-infrared spectroscopy-vascular occlusion test technique was capable of detecting differences in vascular responsiveness during hyperglycaemia between normal-weight individuals and individuals with obesity.

Cited by 18 publications

References 41 publications

Reduced insulin sensitivity in young, normoglycaemic subjects alters microvascular tissue oxygenation during postocclusive reactive hyperaemia

Reduced insulin sensitivity in young, normoglycaemic subjects alters microvascular tissue oxygenation during postocclusive reactive hyperaemia

Effects of a rehabilitation program on microvascular function of CHD patients assessed by near‐infrared spectroscopy

The association between near‐infrared spectroscopy assessment of microvascular reactivity and flow‐mediated dilation is disrupted in individuals at high risk for cardiovascular disease

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