Near-infrared spectroscopy-derived muscle oxygen saturation during exercise recovery and flow-mediated dilation are impaired in HIV-infected patients

Volino-Souza, Mônica; Oliveira, Gustavo Vieira de; Pinheiro, Vivian dos Santos; Machado-Santos, Ana Paula; Conté-Júnior, Carlos Adam; Álvares, Thiago Silveira

doi:10.1016/j.mvr.2020.104004

Cited by 7 publications

(6 citation statements)

References 29 publications

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“…Prior to vascular assessment using NIRS, study subjects should avoid consuming cardiovascular influencers (e.g., alcohol and caffeine) and abstain from exercise for 12 h. Assessments should be performed during a standardized phase of the menstrual cycle in premenopausal women and, for all subjects, in a quiet and temperature-controlled (20°C–21°C) room. If multiple measurements are necessary, tests should be performed at the same time of day [50].…”

Section: Near-infrared Spectroscopymentioning

confidence: 99%

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

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Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.

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Section: Near-infrared Spectroscopymentioning

confidence: 99%

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

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“…The data from the NIRS device were transferred to a laptop and analyzed offline in accordance with other studies that have examined StO 2 during exercise. 29,30 For the baseline StO 2 value, all datapoints were averaged during the 5-minute rest period before the test. The value for the lowest StO 2 value observed during the GXT was recorded and is considered an estimation of oxygen consumption.…”

Section: Near-infrared Spectroscopymentioning

confidence: 99%

“…Finally, the muscle oxygen resaturation rate was calculated by plotting the StO 2 values during the first 12 seconds of recovery after the GXT versus time, fitting a line with simple linear regression, and recording the slope of the line (units: % s 21 ). A 12-second window was chosen for resaturation analysis because of both the sampling rate of the NIRS device (0.25 Hz) and based on other studies that have analyzed oxygen resaturation rates over time periods ranging from 10 to 25 seconds after either exercise [29][30][31] or cuff occlusion. 32,33…”

Section: Near-infrared Spectroscopymentioning

confidence: 99%

Quantification of Tissue Oxygen Saturation in the Vastus Lateralis Muscle of Chronic Stroke Survivors During a Graded Exercise Test

Hyngstrom

Nguyen

Uhrich

et al. 2022

Cardiopulm Phys Ther J

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Purpose:This study examined tissue oxygen saturation (StO2) of the vastus lateralis (VL) muscles of chronic stroke survivors during a graded exercise test (GXT). We hypothesized that the reduction in StO2 will be blunted in the paretic versus nonparetic VL during a maximum effort GXT.Methods:Chronic stroke survivors performed a GXT, and StO2 of the VL in each leg was measured using near-infrared spectroscopy. Twenty-six stroke survivors performed a GXT.Results:At rest, there was no difference in StO2 between the paretic and nonparetic VL (65 ± 9% vs 68 ± 7%, respectively, P = .32). The maximum change in StO2 from rest during the GXT was greater in the nonparetic versus the paretic VL (−16 ± 14% vs −9 ± 10%, respectively, P < .001). The magnitude of the oxygen resaturation response was also greater in the nonparetic versus the paretic VL (29 ± 23% vs 18 ± 15%, respectively, P < .001). VO2 peak was associated with the magnitude of the VL StO2 change during (r2 = 0.54, P < .0001) and after (r2 = 0.56, P < .001) the GXT.Conclusion:During a GXT, there is a blunted oxygen desaturation response in the paretic versus the nonparetic VL of chronic stroke survivors. In the paretic VL, there was a positive correlation between the oxygen desaturation response during the GXT and VO2 peak.

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“…Near-infrared spectroscopy (NIRS) is a non-destructive and almost instantaneous technique that allows high throughput differentiation of biological samples [8]. The LAMBDA 750 is equipped with true double-beam and double-monochromator, designing to provide the highest possible stability and accuracy coupled with lowest straylight performance.…”

Section: Nir Spectra Scanningmentioning

confidence: 99%

Rapid Diagnosis of HIV-1 virus by Near Infrared Spectroscopy: based on Partial least squares regression

Song

Shang

et al. 2021

E3S Web Conf.

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Currently, the laboratory diagnostic tests available for HIV-1 viral infection are mainly based on serological testing which relies on enzyme-linked immunosorbent assay (ELISA) for blood HIV antigen detection and reverse transcription polymerase chain reaction (RT-PCR) for HIV specific RNA sequence identification. However, these methods are expensive and time-consuming, and suffer from false positive and/or false negative results. Thus, there is an urgent need for developing a cost effective, rapid and accurate diagnostic method for HIV-1 infection. In order to reduce the barriers for effective diagnosis, a near-infrared spectroscopy (NIR) method was used to detect the HIV-1 virus in human serum, specifically, three absorption peaks with dose-dependent at 1582nm, 1810nm and 2363nm were found by multiple FBiPLSR test analysis for HIV-nano and HIV-EGFP, but not for MLV. Therefore, we recommend the use of 1582nm, 1810nm and 2363nm as the characteristic spectrum peak, for early screening and rapid diagnosis of serum HIV.

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Near-infrared spectroscopy-derived muscle oxygen saturation during exercise recovery and flow-mediated dilation are impaired in HIV-infected patients

Cited by 7 publications

References 29 publications

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

Quantification of Tissue Oxygen Saturation in the Vastus Lateralis Muscle of Chronic Stroke Survivors During a Graded Exercise Test

Rapid Diagnosis of HIV-1 virus by Near Infrared Spectroscopy: based on Partial least squares regression

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