Near-infrared turn-on fluorescent probe for discriminative detection of Cys and application in <i>in vivo</i> imaging

Qi, Shaolong; Zhu, Lubao; Wang, Xinyu; Du, Jianshi; Yang, Qingbiao; Li, Yaoxian

doi:10.1039/c9ra08555f

Cited by 17 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…91 Qi et al described the water-soluble near-infrared (NIR) probe CYNA design for Cys sensitive and selective recognition by following the literature. 92,93 The absorption result of fluorophore CYNA exhibited the 710 nm emission when Cys concentration is increased in solution; that shows the long emission power of 820 nm, with a very low threshold limit that is 14 nM and has been applied for Cys visualization for mice, and it has wide application in detection and bioimaging of vivo. In the recognition process, the anti-interference capacity of the CYNA molecular probe is also important.…”

Section: Sensing Mechanismmentioning

confidence: 99%

Sensing Mechanism of Cysteine Specific Fluorescence Probes and Their Application of Cysteine Recognition

Asghar,

Li,

Huo

et al. 2024

Chemical & Biomedical Imaging

View full text Add to dashboard Cite

Due to the biological importance of cysteine (Cys), the development of organic fluorescence probes for Cys has been a wide, potent, and outstanding research field in most recent years. It has been used as a biomarker in treating various diseases; therefore, developing a sensing mechanism for detecting Cys is very important. In this Review, we focus on and summarize the specific results of recent exciting literature regarding the sensing mechanism of Cys-specific fluorescence probes and their applications in Cys recognition. Moreover, a design strategy of the sensing mechanism of Cys can be classified into seven reaction mechanisms, including the aromatic substitution rearrangement reaction, cyclization of aldehyde, Michael addition reaction, Se−N or S−S or bond cleavage reaction, addition cyclization of acrylate, metal complex reaction, and nucleophilic substitution reaction. In all sections, discussions have corresponded to Cys-specific sensing mechanisms, which consist of emission, color changes, and detection limits and deal with the application and recognition sites of molecules. Future directions and challenges have been proposed for the preparation of Cys-specific probes.

show abstract

Section: Sensing Mechanismmentioning

confidence: 99%

Sensing Mechanism of Cysteine Specific Fluorescence Probes and Their Application of Cysteine Recognition

Asghar,

Li,

Huo

et al. 2024

Chemical & Biomedical Imaging

View full text Add to dashboard Cite

show abstract

A Pyrene-Based Fluorescent Probe for Specific Detection of Cysteine and its Application in Living Cell

et al. 2021

View full text Add to dashboard Cite

Rational design of a new near-infrared fluorophore and apply to the detection and imaging study of cysteine and thiophenol

Yang

Zhan

et al. 2021

Analytica Chimica Acta

View full text Add to dashboard Cite

Near-infrared turn-on fluorescent probe for discriminative detection of Cys and application in in vivo imaging

Abstract: Near-infrared (NIR) fluorescent probes are widely employed in biological detection because of their lower damage to biological samples, low background interference, and high signal-to-noise ratio.

Cited by 17 publications

References 44 publications

Sensing Mechanism of Cysteine Specific Fluorescence Probes and Their Application of Cysteine Recognition

Sensing Mechanism of Cysteine Specific Fluorescence Probes and Their Application of Cysteine Recognition

A Pyrene-Based Fluorescent Probe for Specific Detection of Cysteine and its Application in Living Cell

Rational design of a new near-infrared fluorophore and apply to the detection and imaging study of cysteine and thiophenol

Contact Info

Product

Resources

About