Near real-time polarimetric imaging system

Buscemi, Isabella Chiara; Guyot, Steve

doi:10.1117/1.jbo.18.11.116002

Cited by 17 publications

(12 citation statements)

References 12 publications

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“…Polarization imaging is an innovative and prospective technology for medical diagnostics. [2][3][4][5][6]9,15,16,[18][19][20][21][22]29,86,132,144,166,170,171,[179][180][181][182][183] The techniques are from the simplest and robust to unique and comprehensive, such as polarized light microscopy (PLM) and ellipsometry, 48,49,76,86,[209][210][211][212][213]217 linear polarization degree mapping and gating, 8,10,19,25,[27][28][29]51,57,60,71,95,152,162,…”

Section: Introductionmentioning

confidence: 99%

Polarized light interaction with tissues

2016

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This tutorial-review introduces the fundamentals of polarized light interaction with biological tissues and presents some of the recent key polarization optical methods that have made possible the quantitative studies essential for biomedical diagnostics. Tissue structures and the corresponding models showing linear and circular birefringence, dichroism, and chirality are analyzed. As the basis for a quantitative description of the interaction of polarized light with tissues, the theory of polarization transfer in a random medium is used. This theory employs the modified transfer equation for Stokes parameters to predict the polarization properties of single- and multiple-scattered optical fields. The near-order of scatterers in tissues is accounted for to provide an adequate description of tissue polarization properties. Biomedical diagnostic techniques based on polarized light detection, including polarization imaging and spectroscopy, amplitude and intensity light scattering matrix measurements, and polarization-sensitive optical coherence tomography are described. Examples of biomedical applications of these techniques for early diagnostics of cataracts, detection of precancer, and prediction of skin disease are presented. The substantial reduction of light scattering multiplicity at tissue optical clearing that leads to a lesser influence of scattering on the measured intrinsic polarization properties of the tissue and allows for more precise quantification of these properties is demonstrated.

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Section: Introductionmentioning

confidence: 99%

Polarized light interaction with tissues

2016

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“…There are four optical anisotropy properties that can be considered: linear birefringence, linear dichroism, circular birefringence, and circular dichroism. The birefringence and dichroism of a material can be determined by measuring changes in the polarisation of light passing through the material, by so-called polarimetry measurements [16][17][18][19]. Polarimetry is a relatively easy technique to implement -at its most simple, requiring only: a light source (laser), polarising filters (and quarter wave plate for circular birefringence and dichroism measurements), and a detector [20,21].…”

Section: Introductionmentioning

confidence: 99%

3D Mueller Matrix Reconstruction of the Optical Anisotropy Parameters of Myocardial Histopathology Tissue Samples

et al. 2021

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Diseases affecting myocardial tissues are currently a leading cause of death in developed nations. Fast and reliable techniques for analysing and understanding how tissues are affected by disease and respond to treatment are fundamental to combating the effects of heart disease. A 3D Mueller matrix method that reconstructs the linear and circular birefringence and dichroism parameters has been developed to image the biological structures in myocardial tissues. The required optical data is gathered using a Stokes polarimeter and then processed mathematically to recover the individual optical anisotropy parameters, expanding on existing 2D Mueller matrix implementations by combining with a digital holography approach. Changes in the different optical anisotropy parameters are rationalised with reference to the general tissue structure, such that the structures can be identified from the anisotropy distributions. The first to fourth order statistical moments characterising the distribution of the parameters of the optical anisotropy of the polycrystalline structure of the partially depolarising layer of tissues in different phase sections of their volumes are investigated and analysed. The third and fourth order statistical moments are found to be the most sensitive to changes in the phase and amplitude anisotropy. The possibility of forensic medical differentiation of death in cases of acute coronary insufficiency (ACI) and coronary heart disease (CHD) is considered as a diagnostic application. The optimal phase plane (θ∗=0.7rad) has been found, in which excellent differentiation accuracy is achieved ACI and CHD -Ac(ΔZ4(θ∗,ΦL,ΔL))=93.05%÷95.8%. A comparative analysis of the accuracy of the Mueller-matrix reconstruction of the parameters of the optical anisotropy of the myocardium in different phase planes (θ=0.9rad and θ=1.2rad), as well as the 2D Mueller-matrix reconstruction method was carried out. This work demonstrates that a 3D Mueller matrix method can be used to effectively analyse the optical anisotropy parameters of myocardial tissues with potential for definitive diagnostics in forensic medicine.

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“…Nowadays, Mueller-matrix polarimetry (MMP) [1][2][3][4][5] approaches are extensively used for the visualization of malformation of biological tissue structure and determination of its functional physiological variations. The MMP now includes a number of popular research directions, such as studies of scattering matrices [6][7][8][9][10], polar decomposition of Mueller matrices [11,12], two-dimensional Mueller-matrix mapping [13][14][15][16], and others. The main disadvantage of MMP is associated with invasive procedure of preparation of bio-tissue samples that significantly limits its application for biomedicine.…”

Section: Introductionmentioning

confidence: 99%

3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis

et al. 2018

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The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method—the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

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Near real-time polarimetric imaging system

Cited by 17 publications

References 12 publications

Polarized light interaction with tissues

Polarized light interaction with tissues

3D Mueller Matrix Reconstruction of the Optical Anisotropy Parameters of Myocardial Histopathology Tissue Samples

3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis

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