Near-tetraploid acute myeloid leukemias: an EGIL retrospective study of 25 cases

Bene, M. C.; Castoldi, Gianluigi; Derolf, Åsa Rangert; Garand, Richard; Haas, T; Haferlach, Torsten; Knapp, Walter; Kühlein, Emilienne; zcaron, P Leme; Wd, Ludwig; Marinov, Iuri; Matutes, Estella; Michalová, K; Porwit‐MacDonald, Anna; Órfão, Alberto; Schoch, Claudia; Talmant, Pascaline; Veer, M. B. Van't; Zemanová, Zuzana; Zühlsdorf, M.

doi:10.1038/sj.leu.2404110

Cited by 57 publications

(89 citation statements)

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“…Such findings are typical for NT-AML at diagnosis [1,3,5] and point to genetic diversity of genetically distinct leukemia-initiating cell subclones [29,30]. A normal karyotype and normal growth of CFU-GM with normal morphological and FCM results were found in CR.…”

Section: Discussionmentioning

confidence: 92%

“…Furthermore, PML/RAR αfusion transcripts were not found in this case. Many features of this patient, such as morphology, CD34 expression, a low growth of CFU-GM, and a higher age, corresponded to NT-AML most frequently found in European patients [1,5] but his bone marrow cells did not exhibit EMD. It seems that the absence of EMD was associated with his unexpected longer survival.…”

Section: Discussionmentioning

confidence: 99%

“…The survival of these 3 patients was not reported. Another case with NT-AML M7 plus 2 extra chromosomes 13 and EMD has been described [1]. …”

Section: Discussionmentioning

confidence: 99%

“…They showed that these patients exhibited erythroblastic and/or megakaryocytic dysplasia (EMD) in bone marrow smears and had poor overall survival after chemotherapy (median 4 months, range 0.1–32) [1]. Other smaller series of NT-AML cases showed similarly poor survival, the longest being 41 months after chemotherapy alone [2,3,4,5,6,7].…”

Section: Introductionmentioning

confidence: 98%

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Unusually Long Survival of a 67-Year-Old Patient with Near-Tetraploid Acute Myeloid Leukemia M0 without Erythroblastic and Megakaryocytic Dysplasia

et al. 2011

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Patients with near-tetraploid acute myeloid leukemia (NT-AML) typically have poor survival. We present the case of a 67-year-old Caucasian male with NT-AML M0 who had an unusually long first complete remission of 51 months and an overall survival of 80 months. The only characteristic distinguishing him from other previously described patients with NT-AML was the absence of erythroblastic and/or megakaryocytic dysplasia (EMD) at diagnosis. Molecular-genetic testing for AML fusion transcripts associated with a favorable prognosis (PML/RARα,AML1/ETO, and CBFβ/MYH11) were negative, as were other prognostic markers like MLL-PTD,FLT3-ITD, or mutations of FLT3-D835,NPM1, or CEBPA. Expression studies of ERG,MN1, and EVI1 revealed overexpression of ERG only. The absence of EMD may be a useful prognostic/diagnostic feature of this new rare subtype of NT-AML.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

“…The survival of these 3 patients was not reported. Another case with NT-AML M7 plus 2 extra chromosomes 13 and EMD has been described [1]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Unusually Long Survival of a 67-Year-Old Patient with Near-Tetraploid Acute Myeloid Leukemia M0 without Erythroblastic and Megakaryocytic Dysplasia

et al. 2011

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“…Tetraploidy (4n, 92 chromosomes) and near-tetraploidy are rare cytogenetic alterations in acute myeloid leukemia (AML) (1). Near-tetraploidy/tetraploidy (NT/T)-AML has been reported to occur preferentially in elderly male patients and is morphologically characterized by very large blasts (2,3).…”

Section: Introductionmentioning

confidence: 99%

Near Tetraploidy Acute Myeloid Leukemia in Long-term Remission with Persistent Clonal Hematopoiesis with del(20)(q12q13)

et al. 2018

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Abstract:Patients with near tetraploidy/tetraploidy (NT/T)-acute myeloid leukemia (AML) are rare and generally show poor survival. A 62-year-old man was referred to our hospital with pancytopenia. A bone marrow examination revealed the proliferation of extremely large blasts, and led to the diagnosis of AML M0. A cytogenetic analysis showed an NT-karyotype of 91, XXYY, -5, add(18)(p21),del(20)(q12q13)×2. Complete remission was achieved with single remission induction chemotherapy. Although consolidation chemotherapies were not available because of his critical condition, he remained in remission and survived for more than 40 months without cytopenia. However, repeated bone marrow examinations showed persistent clonal hematopoiesis with del(20)(q12q13) without apparent myelodysplasia.

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Acute Myeloid Leukaemia

2014

Morphology of Blood Disorders

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Near-tetraploid acute myeloid leukemias: an EGIL retrospective study of 25 cases

Cited by 57 publications

References 5 publications

Unusually Long Survival of a 67-Year-Old Patient with Near-Tetraploid Acute Myeloid Leukemia M0 without Erythroblastic and Megakaryocytic Dysplasia

Unusually Long Survival of a 67-Year-Old Patient with Near-Tetraploid Acute Myeloid Leukemia M0 without Erythroblastic and Megakaryocytic Dysplasia

Near Tetraploidy Acute Myeloid Leukemia in Long-term Remission with Persistent Clonal Hematopoiesis with del(20)(q12q13)

Acute Myeloid Leukaemia

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