Near-wall resolution and wall modeling for lattice Boltzmann simulations of mechanically agitated vessels

Flamm, Matthew H.; Kálal, Zbyněk

doi:10.1016/j.ces.2022.118172

Chemical Engineering Science

2022

DOI: 10.1016/j.ces.2022.118172

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Near-wall resolution and wall modeling for lattice Boltzmann simulations of mechanically agitated vessels

Matthew H. Flamm¹,

Zbyněk Kálal²

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2024

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Cited by 1 publication

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Development and qualification of 3 L scale‐down model for large scale vaccine process on Vero cell culture using microcarriers

Huang,

Wang,

Flamm

et al. 2024

Biotech & Bioengineering

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Scale‐down models (SDM) are pivotal tools for process understanding and improvement to accelerate the development of vaccines from laboratory research to global commercialization. In this study, a 3 L SDM representing a 50 L scale Vero cell culture process of a live‐attenuated virus vaccine using microcarriers was developed and qualified based on the constant impeller power per volume principle. Both multivariate data analysis (MVDA) and the traditional univariate data analysis showed comparable and equivalent cell growth, metabolic activity, and product quality results across scales. Computational fluid dynamics simulation further confirmed similar hydrodynamic stress between the two scales.

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Development and qualification of 3 L scale‐down model for large scale vaccine process on Vero cell culture using microcarriers

Huang,

Wang,

Flamm

et al. 2024

Biotech & Bioengineering

View full text Add to dashboard Cite

show abstract

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Near-wall resolution and wall modeling for lattice Boltzmann simulations of mechanically agitated vessels

Cited by 1 publication

References 48 publications

Development and qualification of 3 L scale‐down model for large scale vaccine process on Vero cell culture using microcarriers

Development and qualification of 3 L scale‐down model for large scale vaccine process on Vero cell culture using microcarriers

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