Nearly one third of adults in the ‘healthy’ BMI range are at early cardiometabolic risk according to their waist-to-height ratio

Ashwell, Margaret; Gibson, Sigrid

doi:10.1017/s0029665119000338

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…These findings support previous studies (38,41,42) where we showed that men and women with a BMI in the 'healthy' range but WHtR ≥ 0•5 had increased levels of cardiometabolic risk factors, not only when compared with participants with 'healthy' BMI and WHtR < 0•5, but also when compared with overweight participants (BMI > 25 kg/m 2 ) with low WHtR < 0•5. In the present study, we suggest that the 'matrix' underperforms compared with WHtR because it considers individuals with moderately high WC (80-88 cm for women, 94-102 cm for men) not to be at risk unless they are also overweight.…”

Section: Comparison With Analyses Of Previous Uk Datasupporting

confidence: 92%

“…Others diagnose NWCO from BMI and WHtR and have shown that it can be associated with increase morbidity (47)(48)(49)(50) and increased mortality (51,52) . The extent of NWCO in UK has previously been estimated as nearly one-third of the adult population, based on those in normal BMI range with WHtR > 0•5 (42) . Results of the present study show that even when WC is taken into account, more than 30 % of the participants in the 'no increased risk' category (based on the 'matrix') have WHtR > 0•5.…”

Section: Normal Weight Central Obesitymentioning

confidence: 99%

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A simple cut-off for waist-to-height ratio (0·5) can act as an indicator for cardiometabolic risk: recent data from adults in the Health Survey for England

Gibson

Ashwell

2019

Br J Nutr

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The National Institute for Health and Care Excellence (NICE) has acknowledged the value of waist-to-height ratio (WHtR) as an indicator for ‘early health risk’. We used recent UK data to explore whether classification based on WHtR identifies more adults at cardiometabolic risk than the ‘matrix’ based on BMI and waist circumference, currently used for screening. Data from the Health Survey for England (4112 adults aged 18+ years) were used to identify cardiometabolic risk, indicated by raised glycated Hb, dyslipidaemia and hypertension. HbA1c, total/HDL-cholesterol and systolic blood pressure (BP) were more strongly associated with WHtR than the ‘matrix’. In logistic regression models for HbA1c ≥ 48 mmol/mol, total/HDL-cholesterol > 4 and hypertension (BP > 140/90 mmHg or on medication), WHtR had a higher predictive value than the ‘matrix’. AUC was significantly greater for WHtR than the ‘matrix’ for raised HbA1c and hypertension. Of adults with raised HbA1c, 15 % would be judged as ‘no increased risk’ using the ‘matrix’ in contrast to 3 % using WHtR < 0·5. For hypertension, comparative values were 23 and 9 %, and for total/HDL-cholesterol > 4, 26 and 13 %. Nearly one-third of the ‘no increased risk’ group in the ‘matrix’ had WHtR ≥ 0·5 and hence could be underdiagnosed for cardiometabolic risk. WHtR has the potential to be a better indicator of cardiometabolic risks associated with central obesity than the current NICE ‘matrix’. The cut-off WHtR 0·5 in early screening translates to a simple message, ‘your waist should be less than half your height’, that allows individuals to be aware of their health risks.

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Section: Comparison With Analyses Of Previous Uk Datasupporting

confidence: 92%

Section: Normal Weight Central Obesitymentioning

confidence: 99%

A simple cut-off for waist-to-height ratio (0·5) can act as an indicator for cardiometabolic risk: recent data from adults in the Health Survey for England

Gibson

Ashwell

2019

Br J Nutr

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“…This is well addressed in various scientific findings. 66 , 67 Individuals who have increased WHtR could also be prone to develop, CAD, NAFLD, or stroke. 68 – 72 This ratio determination has also been shown to be a better predictor of CIMT advancement than HDL-C or LDL-C alone in a prospective investigation.…”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia and associated cardiovascular risk factors in HIV-positive and HIV-negative patients visiting ambulatory clinics: A hospital-based study

Woldu

Minzi

Engidawork

2022

JRSM Cardiovascular Disease

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Background Dyslipidemia is a well-known risk factor for cardiovascular disease (CVD), accounting for more than half of all instances of coronary artery disease globally (CAD). Purpose The purpose of this study was to determine lipid-related cardiovascular risks in HIV-positive and HIV-negative individuals by evaluating lipid profiles, ratios, and other related parameters. Methods A hospital-based study was carried out from January 2019 to February 2021 in both HIV + and HIV- ambulatory patients. Results High TG (p = .003), high TC (p = .025), and low HDL (p < .001) were all associated with a two-fold increased risk of CVD in people aged 45 and up. Due to higher TG (p < .001) and lower HDL (p < .001), males were found to have a higher risk of atherogenic dyslipidemia. A twofold increase in the likelihood of higher TG levels has been associated with smoking (p = .032) and alcohol intake (p = .022). A twofold increase in a high TC/HDL ratio and an elevated TG/HDL ratio was observed with an increase in waist-to-height ratio (p = .030) and a high level of FBS (126 mg/dl) and/or validated diabetes (p = .017), respectively. In HIV + participants, central obesity (p < .001), diabetes (p < .001), and high blood pressure (p < .001) were all less common than in HIV- participants. Conclusions Dyslipidemia is linked to advanced age, male gender, diabetes, smoking, alcohol consumption, and increased waist circumference, all of which could lead to an increased risk of CVD, according to the study. The study also revealed that the risks are less common in HIV + people than in HIV-negative ambulatory patients.

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Nearly one third of adults in the ‘healthy’ BMI range are at early cardiometabolic risk according to their waist-to-height ratio

Cited by 2 publications

References 3 publications

A simple cut-off for waist-to-height ratio (0·5) can act as an indicator for cardiometabolic risk: recent data from adults in the Health Survey for England

A simple cut-off for waist-to-height ratio (0·5) can act as an indicator for cardiometabolic risk: recent data from adults in the Health Survey for England

Dyslipidemia and associated cardiovascular risk factors in HIV-positive and HIV-negative patients visiting ambulatory clinics: A hospital-based study

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